CV Lattes
Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciencias Biológicas from Universidade Estadual de Maringá (2008), master's at Biochemistry from Universidade Estadual de Campinas (2011) and doctorate at Biochemistry from Universidade Estadual de Campinas (2015). (Source: Lattes Curriculum)
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Diabetes Mellitus (DM) is characterized by chronic hyperglycemia, resulting from a partial or total reduction of insulin, due the partial or total destruction of pancreatic beta cell mass. Recover beta cell mass and consequently the insulin secretion is crucial for the treatment of DM. It was demonstrated that non-beta cells of pancreas (endocrine and non-endocrine) have the ability to re…
ARHGAP21 is a Rho-GAP that, like Cdc42 and FAK, modulates the activity of proteins involved with rearrangement of actin cytoskeleton in pancreatic beta cell, leading the inhibition of insulin secretion. Furthermore, glucose modulates the ARHGAP21/FAK and ARHGAP21/Cdc42 interactions, which may explain, at least in part, the control of insulin secretion by ARHGAP21. However, the pathways by…
The pancreatic delta cell is the third more abundant cell in pancreatic islet, and inhibits, in a paracrine-fashion, through somatostatin, both insulin and glucagon secretion and, consequently, modulate glucose homeostasis. Recently, it was shown that somatostatin secretion is stimulated by UCN3, which is secreted together with insulin by beta cell. In a preliminary study, we observed tha…
| 3 / 3 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
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