CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Odontologia (FOAr) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Odontologia Integral from Universidade Estadual Paulista Júlio de Mesquita Filho (1988), master's at Morphology from Universidade Federal de São Paulo (1995) and doctorate at Morphology from Universidade Federal de São Paulo (2000). He is currently orientador - pós-graduação em morfologia at Universidade Federal de São Paulo. Has experience in Morphology, acting on the following subjects: morfometria, imuno-histoquímica, apoptose, biocompatibilidade and materiais endodônticos. (Source: Lattes Curriculum)
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Periodontitis (P), triggered by subgingival bacterial accumulation, causes the periodontal tissues degradation (gingiva, cementum, periodontal ligament and bone alveolar). Bone loss is considered as hallmark of progression of P. Therefore, the bone loss resulting of P is closely associated with osteoclast formation, activity and survival. Cytokines such as interleukin-1 (IL-1), IL-6, tumo…
The degradation of tissues of the eruptive pathway occurs during tooth eruption, including the lamina propria and bone located between tooth germ and oral mucosa. The eruptive pathway degradation depends on a complex cascade of cellular and molecular events that occur at specific sites and time. It is known that TNF-± and IL-1 are involved in osteoclastogenesis and activation of metallopr…
Bone tissue, a specialized connective tissue, is constituted by different cell types (lining cells, osteoblasts, osteocytes and osteoclasts) and a mineralized extracellular matrix. The periodontium comprises the structures responsible for maintaining the tooth in the maxillary and mandibular bones and consists of: cementum, periodontal ligament, alveolar bone and gingiva. The alveolar pro…
(Only some records are available in English at this moment)
Periodontitis is an immunoinflammatory disease characterized by recruitment of immune system cells that release mediators, such as tumour necrosis factor-alpha (TNF-±), interleukin-1² (IL-1²), IL-6 and matrix metalloproteinases. These cytokines promote degradation of extracellular matrix components as well as osteoclast formation and activity, culminating in the bone loss. Therefore, the …
Periodontitis (P) and type 2 diabetes mellitus (T2DM) are complex and multifactorial chronic diseases, characterized by a hyper-inflammatory state. The immunoinflammatory state promotes the recruitment of specific cells that release mediators, such as interleukin-1² (IL-1²), IL-6, IL-7, tumor necrosis factor-alpha (TNF-±), and matrix metalloproteinases (MMPs). Therefore, the modulation of…
The evaluation of the biological behavior for the formation of mineralized tissue of reparative materials in direct contact with dental pulp is of paramount importance in the field of dentistry. These materials are commonly employed in restorative procedures, where it is crucial to protect and preserve the integrity of dental pulp. The aim of this study will be to evaluate in vivo the bio…
Periodontitis (P) is a multifactorial and immunoinflammatory disease that culminates with the degradation of periodontal tissues (soft and hard tissues). P progression is under a complex control of several mediators including interleukin-1 (IL-1), tumor necrosis factor-alpha (TNF-±), matrix metalloproteinases (MMPs). These mediators promote the osteoclast formation, differentiation and ac…
Periodontitis (P) is a multifactorial disease triggered by the host response to the accumulation of bacteria in the gingival sulcus, which can be influenced by several factors, among them systemic, environmental, trauma and drugs. The periodontitis progression is mediated by some bioactive agents such as interleukins (IL), matrix metalloproteinases (MMP) and transcription factors that int…
(Only some records are available in English at this moment)
| 1 / 0 | Ongoing grants |
| 6 / 5 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 18 / 15 | Completed scholarships in Brazil |
| 27 / 22 | All research grants and scholarships |
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