Abstract
Periodontitis (P), triggered by subgingival bacterial accumulation, causes the periodontal tissues degradation (gingiva, cementum, periodontal ligament and bone alveolar). Bone loss is considered as hallmark of progression of P. Therefore, the bone loss resulting of P is closely associated with osteoclast formation, activity and survival. Cytokines such as interleukin-1 (IL-1), IL-6, tumo…