Mauri Sergio Alves Palma
CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Engenharia Química from Universidade Estadual de Campinas (1983), master's at Chemical Engineering from Universidade de São Paulo (1991) and doctorate at Chemical Engineering from Universidade de São Paulo (2002). He is currently professor dr. ms-3.2 at Universidade de São Paulo. Has experience in Chemical Engineering, focusing on Operations of Separation and Mixture, acting on the following subjects: fenol, batch process, processo batelada, fenton and microrreatores. (Source: Lattes Curriculum)
- Synthesis of Pioglitazone, Rosiglitazone and Lobeglitazone in continuous flow in capillary microreactors, AP.R
Abstract
Microreactors offer excellent heat and mass transfer, high surface/volume ratio with laminar flow and without axial dispersion. Microreactors have been used in the continuous-flow synthesis of pharmaceuticals, creating chemical libraries of compounds with pharmacological potential, continuous synthesis in multiple steps, particularly for rapid reactions that involve much heat, chemical ...
- Micro-reactors in the synthesis of pharmaceuticals, AP.R
Abstract
Microreactors offer excellent heat and mass transfer, high surface/volume ratio with laminar flow and without axial dispersion. Microreactor have been used in the continuous-flow synthesis of pharmaceuticals, creating chemical libraries of compounds with pharmacological potential, continuous synthesis in multiple steps, particularly for rapid reactions that involve much heat, intensive ...
- Rosiglitazone synthetic route development in batch process and capillary microreactor, BP.DD
Abstract
The chemical-pharmaceutical industries in Brazil employ batch reactors for the synthesis processes, however, they have limitations on temperature, operating pressure and mixing efficiency. The flow process in microreactors provides the reduction of the impact generated by the processes with substantial waste reduction. In addition, they provide an expressive increase in mass and heat tr...
- Synthesis of pioglitazone in batch and capillary microreactor, BP.DR
Abstract
Continuous flow microreactors have been used as an alternative over batch reactors due to their advantages, such as excellent heat exchange control due to the high surface/volume ratio, more efficient homogenization due to the small distances for diffusion, leading to increase the rate of chemical reaction, conversion, yield, selectivity and safety when working with reagents and toxic p...
- Synthesis of (z)-5-(4-fluorobenzylidene)thiazolidine-2,4-dione, an intermediate of Rosiglitazone, in batch and capillary micro reactor, BP.IC
Abstract
The present project aims at the synthesis of (Z)-5-(4-fluorobenzylidene)thiazolidine-2,4-dione, an intermediate of the Active Pharmaceutical Ingredient Rosiglitazone, which is one of the anti-glycemic agents of the class of glitazones, used to treat diabetes mellitus type 2, an insulin sensitization substance for humans. The synthesis of this intermediate will be made through the reacti...
- Synthesis of intermediates of pioglitazone in batch process and capillary microreactor, BP.IC
Abstract
Chemical-pharmaceutical industries in Brazil employ batch reactors for synthesis processes, however, batch reactors have limitations as to temperature, pressure and mixing efficiency. The use of microreactors emerges as innovation for high demand in industries. The microchannels in the microreactors promote higher and more efficient mass and heat transfer, which enables a process easily...
- Transposition of the synthesis of Pioglitazone from the batch process to flow process in capillary microreactor, BP.IC
Abstract
The use of microreactors in chemical-pharmaceutical industries provides a number of advantages because of your reduced size compared to batch reactors, which are more commonly used for this type of industry. These advantages can be associated with the drastic reduction of reaction times, due to the elimination of inefficient mixing effects and the reduction of waste generation causing a...
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 7 / 1 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 16 / 7 | Completed scholarships in Brazil |
| 26 / 11 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 3 |
| Citations | 3 |
| Cit./Article | 1.0 |
| Data from Web of Science | |
PINHEIRO, DANILO DA SILVA; DE OLIVEIRA SILVA, RENAN RODRIGUES; CUESTA CALVO, PAULO VICTOR; DA SILVA, MILENA FERNANDES; CONVERTI, ATTILIO; ALVES PALMA, MAURI SERGIO. Microreactor Technology as a Tool for the Synthesis of a Glitazone Drug Intermediate. CHEMICAL ENGINEERING & TECHNOLOGY, v. 41, n. 9, p. 1800-1807, SEP 2018. Web of Science Citations: 2. (14/07757-2)
DE OLIVEIRA SILVA, RENAN RODRIGUES; CUESTA CALVO, PAULO VICTOR; DA SILVA, MILENA FERNANDES; SOLISIO, CARLO; CONVERTI, ATTILIO; ALVES PALMA, MAURI SERGIO. Flow Synthesis of a Thiazolidine Drug Intermediate in Capillary Microreactors. CHEMICAL ENGINEERING & TECHNOLOGY, v. 42, n. 2, p. 465-473, FEB 2019. Web of Science Citations: 1. (14/07757-2)
SIGUEMOTO, ERICA S.; LEITE RECHE, LEANDRO; GUT, JORGE A. W.; PALMA, MAURI S. A.. Residence Time Distribution of a Capillary Microreactor Used for Pharmaceutical Synthesis. CHEMICAL ENGINEERING & TECHNOLOGY, v. 43, n. 3, JAN 2020. Web of Science Citations: 0. (13/07914-8, 17/12830-9, 14/07757-2)
(References retrieved automatically from State of São Paulo Research Institutions)
PALMA, Mauri Sergio Alves. Polimerização de acetato de vinila em emulsão de modo contínuo em coluna pulsada de pratos perfurados.. Tese (Doutorado) - Escola Politécnica. Universidade de São Paulo (USP). São Paulo. (98/00800-5)