CV Lattes
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Universidade de São Paulo (USP). Faculdade de Ciências Farmacêuticas (FCF) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Engenharia Química from Universidade Estadual de Campinas (1983), master's at Chemical Engineering from Universidade de São Paulo (1991) and doctorate at Chemical Engineering from Universidade de São Paulo (2002). Has experience in Chemical Engineering, focusing on Operations of Separation and Mixture, acting on the following subjects: batch process, fenol, microrreatores, processo batelada and fenton. (Source: Lattes Curriculum)
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The synthesis of pharmaceutic drugs in flow has significant advantages over the usual batch process. The main reason is the high added value and low consumption of supplies during the synthesis of pharmaceutic drugs. Some advantages of drug synthesis in micro- and milli-reactors are the drastic reduction of reaction times due tothe elimination of inefficient mixing effects, increased yiel…
The synthesis of drugs in flow has significant advantages over the usual batch process and, due to the high added value and low demand of the drugs, there is great potential in the expansion of its synthesis in in flow in micro-milirreactors, which allow excellent heat and mass transfer, very high surface/volume ratio with a laminar and pistonflow and have also been used in the creation o…
Microreactors offer excellent heat and mass transfer, high surface/volume ratio with laminar flow and without axial dispersion. Microreactors have been used in the continuous-flow synthesis of pharmaceuticals, creating chemical libraries of compounds with pharmacological potential, continuous synthesis in multiple steps, particularly for rapid reactions that involve much heat, chemical pr…
Microreactors offer excellent heat and mass transfer, high surface/volume ratio with laminar flow and without axial dispersion. Microreactor have been used in the continuous-flow synthesis of pharmaceuticals, creating chemical libraries of compounds with pharmacological potential, continuous synthesis in multiple steps, particularly for rapid reactions that involve much heat, intensive ch…
Microreactor technology is an excellent tool for increasing the efficiency of chemical reactions, as it improves the control of thermal exchange, reaction kinetics, and mass transfer, allowing for increased pharmaceutical production with less waste generation, such as Metoprolol®, a beta-blocker that reduces blood pressure by inhibiting adrenaline receptors. Thus, microreactors enable hig…
This project aims to synthesize N-(2,6-dimethylphenyl)chloroacetamide, a key intermediate in the synthesis route of Ranolazine, a medication used in the treatment of angina, characterized by temporary chest pain due to a lack of oxygen in the cardiac muscle. Ranolazine is approved as an antianginal for patients with stable coronary artery disease and is often administered in combination w…
The present project aims to synthesize N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide, an intermediate in the synthesis of the drug Ranolazine®, used in the treatment of chronic angina. The synthesis of this intermediate will be carried out through the reaction of piperazine and 2-chloro-N-(2,6-dimethylphenyl)acetamide, with the main goal of transitioning the reaction from conventiona…
(Only some records are available in English at this moment)
Coconut water is a product with high economic value and still has few processing alternatives. The use of continuous flow microreactors in the chemical-pharmaceutical industry is a growing field. The advantages of using this technology are also interesting for the food industry and the thermal processing of low viscosity liquids is already proving to be an interesting alternative to con…
The chemical-pharmaceutical industries in Brazil use batch reactors for synthesis processes, however, this process has limitations regarding temperature, pressure and mixing efficiency. The use of microreactors in the chemical-pharmaceutical industries reduces the impact generated by processes with a substantial reduction in waste. Furthermore, they provide a significant increase in mass …
The flow syntheses of Active Pharmaceutical Ingredients (APIs) have significant advantages over the usual batch process and, due to the high added value and low demand of drugs, there is a great potential for the flow syntheses in micro reactors. The main characteristics of micro reactors are excellent heat and mass transfer, high surface/volume ratio with laminar and plug flow. The micr…
(Only some records are available in English at this moment)
Conventional thermal processing methods cause changes in characteristics such as taste,aroma, texture and decrease the nutritional value. Pulsed electric field technology is aninnovative technology in several areas of the food industry and bioprocess engineering andcan be used as a food processing technology with the advantage of preserving sensory andnutritional characteristics. Thus, th…
| 2 / 2 | Ongoing grants |
| 8 / 2 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 27 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 43 / 28 | All research grants and scholarships |
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