- Research Grants
Luciano Abreu Brito in research grants and scholarships supported by FAPESP.
|News published in Agência FAPESP Newsletter about the researcher|
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Orofacial clefts comprehend a heterogeneous group of defects of the lip and palate, of which the most prevalent subgroup is nonsyndromic cleft lip with or without cleft palate (NS CL/P). NS CL/P is a complex disease highly genetically determined. However, the major associated loci are common variants that do not account for the disease's heritability. Given the burden on health system r...
Nonsyndromic cleft lip with or without cleft palate (NS CL/P) is a complex disease that represents the most common craniofacial defect at birth. A genetic role in the etiology of NS CL/P is strongly suggested, but the only susceptibility loci widely corroborated (the IRF6 gene and a gene desert at 8q24 region) increase low risk to the disease. Considering the recent failures of linkage ...
CDH1 encodes the epithelial cadherin, a key molecule to establish the adherens junctions in epithelial cells and also involved in epithelial-mesenchymal transition, a mechanism that plays a central role on the embryogenesis of the lip and palate. We have recently identified, through exome analysis, two missense mutations in CDH1 (c.G760A and c.G2351A) underlying three familial cases of ...
(References retrieved automatically from State of São Paulo Research Institutions)
BRITO, Luciano Abreu. Identificação de genes de suscetibilidade às fissuras labiopalatinas não sindrômicas: influência da epidemiologia e da estratificação populacional. Dissertação (Mestrado) - Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (09/04183-7)
BRITO, Luciano Abreu. Variantes genéticas de risco às fissuras orofaciais. Tese (Doutorado) - Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (11/23416-2)