Abstract
Orofacial clefts comprehend a heterogeneous group of defects of the lip and palate, of which the most prevalent subgroup is nonsyndromic cleft lip with or without cleft palate (NS CL/P). NS CL/P is a complex disease highly genetically determined. However, the major associated loci are common variants that do not account for the disease's heritability. Given the burden on health system rep…