Luciano Abreu Brito
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Luciano Abreu Brito in research grants and scholarships supported by FAPESP.
| News published in Agência FAPESP Newsletter about the researcher |
| Brazil will have the technology to transplant pig organs into humans |
- Investigation of the etiological relevance of novel candidate genes to orofacial clefts, BP.PD
Abstract
Orofacial clefts comprehend a heterogeneous group of defects of the lip and palate, of which the most prevalent subgroup is nonsyndromic cleft lip with or without cleft palate (NS CL/P). NS CL/P is a complex disease highly genetically determined. However, the major associated loci are common variants that do not account for the disease's heritability. Given the burden on health system r...
- A genomic analysis to comprehend the genetic mechanisms of cleft lip and palate in Brazilian population, BP.DR
Abstract
Nonsyndromic cleft lip with or without cleft palate (NS CL/P) is a complex disease that represents the most common craniofacial defect at birth. A genetic role in the etiology of NS CL/P is strongly suggested, but the only susceptibility loci widely corroborated (the IRF6 gene and a gene desert at 8q24 region) increase low risk to the disease. Considering the recent failures of linkage ...
- Investigation of predisposition genes to cleft lip with or without cleft palate in brazilian population, BP.MS
- Functional study of CDH1 mutations implicated in cleft lip and palate through CRISPR-Cas9 genome editing approach in zebrafish, BE.EP.DR
Abstract
CDH1 encodes the epithelial cadherin, a key molecule to establish the adherens junctions in epithelial cells and also involved in epithelial-mesenchymal transition, a mechanism that plays a central role on the embryogenesis of the lip and palate. We have recently identified, through exome analysis, two missense mutations in CDH1 (c.G760A and c.G2351A) underlying three familial cases of ...
| 1 / 1 | Ongoing scholarships in Brazil |
| 2 / 2 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 4 / 4 | All Scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 2 |
| Citations | 0 |
| Cit./Article | 0.0 |
| Data from Web of Science | |
HSIA, GABRIELLA S. P.; MUSSO, CAMILA M.; ALVIZI, LUCAS; BRITO, LUCIANO A.; KOBAYASHI, GERSON S.; PAVANELLO, RITA C. M.; ZATZ, MAYANA; GARDHAM, ALICE; WAKELING, EMMA; ZECHI-CEIDE, ROSELI M.; et al. Complexity of the 5 ` Untranslated Region of EIF4A3, a Critical Factor for Craniofacial and Neural Development. FRONTIERS IN GENETICS, v. 9, APR 25 2018. Web of Science Citations: 0. (13/08028-1, 15/21781-6)
MASOTTI, C.; BRITO, L. A.; NICA, A. C.; LUDWIG, K. U.; NUNES, K.; SAVASTANO, C. P.; MALCHER, C.; FERREIRA, S. G.; KOBAYASHI, G. S.; BUENO, D. F.; et al. MRPL53, a New Candidate Gene for Orofacial Clefting, Identified Using an eQTL Approach. JOURNAL OF DENTAL RESEARCH, v. 97, n. 1, p. 33-40, JAN 2018. Web of Science Citations: 0. (13/08028-1)
(References retrieved automatically from State of São Paulo Research Institutions)
BRITO, Luciano Abreu. Identificação de genes de suscetibilidade às fissuras labiopalatinas não sindrômicas: influência da epidemiologia e da estratificação populacional. 2011. Dissertação (Mestrado) - Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (09/04183-7)
BRITO, Luciano Abreu. Variantes genéticas de risco às fissuras orofaciais. 2016. Tese (Doutorado) – Instituto de Biociências. Universidade de São Paulo (USP). São Paulo. (11/23416-2)