CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina (FM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Medicina from Pontifícia Universidade Católica de São Paulo (1988) and doctorate at Medicina from Universidade de São Paulo (1997). Has experience in Medicine, focusing on Endocrinology, acting on the following subjects: diabetes mellitus (Source: Lattes Curriculum)
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Bariatric surgery in the treatment of obesity determines sustained weight loss and improves metabolic outcomes, including remission of type 2 diabetes mellitus (T2D). Roux-en-Y gastric bypass (RYGB) is one of the most frequently employed modalities and the mechanisms suggested to explain its beneficial effects on glucose tolerance include a negative energy balance with weight loss and con…
Diabetes Mellitus (DM) and its chronic complications are the greatest public health problem. It is a must to develop approaches that help to control glycemia and to reduce the incidence of complications. Target territories to develop complications, which will be focused on in this proposal, include kidney, cardiovascular system, brain (Alzheimer's Disease also referred to as DM3) and live…
(Only some records are available in English at this moment)
Diabetes mellitus (DM), especially type 2 DM (T2D), is a highly prevalent condition; in 2021, the Surveillance of Risk or Protective Factors for Chronic Diseases by Telephone Survey in the State of São Paulo (Vigitel ESP) estimated the number of adult individuals with DM in this state at 3,178,067. The history of DM is marked by microvascular complications in those who cannot maintain goo…
Pancreatic ductal adenocarcinoma (PDCA) is a neoplasm with dismal prognosis usually diagnosed at advanced stages, when surgery is not a therapeutic option. New-onset diabetes mellitus (DM) is a paraneoplastic manifestation of PDAC and constitutes a window of opportunity for its early diagnosis, since it appears between 24 and 36 months before the diagnosis of the tumor in 80% of the patie…
Epidemiological studies have shown that Diabetes mellitus and Obesity are risk factors for the genesis and progression of Alzheimer's Disease. In the last decade, studies have demonstrated insulin resistance in some brain regions of patients with Alzheimer's Disease (AD), suggesting that impairment of glucose supply to neuronal cells may be a key element in the onset and progression of ne…
Roux-en-Y Gastric Bypass (RYGB) is an effective method to treat Obesity and its metabolic effects include early glycemic control, even before significant weight loss. However, in clinical practice it is common that some patients don't achieve complete Type 2 Diabetes (T2D) remission, or some of them have the T2D recurrence in long-term. The mechanisms involved in T2D early remission and l…
The pathophysiological mechanisms involved in the genesis of diabetic nephropathy (DN) have not been fully elucidated. Nonetheless it is well established that oxidative stress plays a key role in the development of this complication in type 1 diabetes mellitus (T1D). The study of biochemical pathways associated with the development of DN in humans is complicated by the need of renal biops…
(Only some records are available in English at this moment)
Diabetic kidney disease (DKD) is a major cause of end-stage renal disease worldwide. In humans, the study of potentially pathways associated with its development and progression is complicated by the need for renal biopsy. In recent years, the availability of more sensitive techniques of molecular biology has increased the use of urine in the study of renal diseases. Besides being an orga…
Introduction: Diabetic nephropathy (DN) is the most common cause of endstage renal disease worldwide and new therapies are urgently needed. The studies focusing in new mechanistic insights into the (patho)physiology of renal injury in diabetes, as well as potentially leading to the development of novel therapeutic interventions in DN, through targeting non-coding RNA-regulated epigenetic …
Evidences suggest that a genetic predisposition determines susceptibility to chronic complications of diabetes mellitus (DM), along with chronic hyperglycemia, hypertension and dyslipidemia. Since oxidative stress has been recognized as the final element of common biochemical pathways induced by hyperglycemia, the genes that encode pro-and antioxidant enzymes are candidates to confer susc…
| 14 / 8 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 25 / 11 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 44 / 24 | All research grants and scholarships |
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