CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Instituto Nacional de Farmacologia (INFAR) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Ciencias Biologicas Modalidade Medica from Universidade Federal de São Paulo (1970), graduate at Biologia from Universidade de São Paulo (1971) and ph.d. at Biochemistry from Universidade Federal de São Paulo (1974). Has experience in Biochemistry, focusing on Chemistry of Macromolecules, acting on the following subjects: heparina, heparam sulfato, heparin, glicosaminoglicanos and heparam. (Source: Lattes Curriculum)
Among the rare diseases, mucopolysaccharidoses I and II (MPS I and II) are particularly common in the states of São Paulo and Rio Grande do Sul and are caused by mutations in genes encoding lysosomal proteins (enzymes). The currently available treatments are not curative and are particularly inefficient for the prevention of neurological symptoms. In addition, they cost millions of dollar…
The glycoconjugates, including glycosaminoglycans (GAGs), belong to the most abundant class of structurally diverse and heterogeneous molecules present in the extracellular matrix and on the cell surface. Unlike nucleic acids and proteins, the information necessary for their biosynthesis does not have a known code. The diverse and heterogeneous structures are the result of the action of g…
Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the new SARS-CoV-2 coronavirus outbreak. Traditional drug development processes are slow and ineffective against such emerging public health threats. Repurposing existing drugs that are capable of preventing and treating novel coronavirus infections is a timely and…
(Only some records are available in English at this moment)
The project "70 years of the Brazilian Society for the Progress of Science (SBPC), Past & Present designing the Future" focus on the work of the Society with impact in the policies of science, education, innovation, health and environment. SBPC is a unique Society in Latin American, in continuous activity since 1948. The research product will be a book base in historical process of the So…
(Only some records are available in English at this moment)
Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the new SARS-CoV-2 Coronavirus outbreak. Traditional drug development processes are slow and ineffective against such emerging public health threats. Repurposing existing drugs that are capable of preventing and treating novel Coronavirus infections is a timely and…
It has been assumed that the biosynthesis of Heparan Sulfate ((HS) occurs through a hierarchical sequence of enzymatic events, involving polymerization, sulfation and epimerization, and the 3-O-sulfotransferase (HS3ST) is the last enzyme in this sequence of events. However, we have recently shown that HS3ST can act at different stages of HS biosynthesis and besides enzyme specificity, oth…
Syndecans (Syn) are heparan sulfate proteoglycans characterized as transmembrane receptors that act cooperatively with the interior of cells and components the extracellular matrix. Syn4 knockdown was performed to address its role in endothelial cell (EC) behavior. Syn4 knockdown showed changes in the amount and arrangement of the proteins essential for focal adhesion, evidenced by the de…
Mucopolysaccharidosis type I (MPS I) is an autossomic recessive disease caused by lysosomal alfa-L-iduronidase deficiency, leading to accumulation of glycosaminoglycans (GAGs), mainly heparin and dermatan sulfate, in several organs and tissues. In addition to deposit, structural modifications in accumulated GAG chains can also affect the signalization of different molecules including grow…
Glycoproteins are the most abundant forms of proteins in complex organisms, and this post-translational modification is responsible for many of the fine control mechanisms that coordinate the events that allow the existence of complex life. Sindecan-4 (Syn4), transmembrane proteoglycans, plays an important role in cellular behavior, due to its interaction via Heparan Sulfate (HS) chains, …
(Only some records are available in English at this moment)
Glycoconjugates, including proteoglycans, belong to the most abundant class of structurally diverse and heterogeneous molecules present in the extracellular matrix (ECM) and on the cell surface. Syndecan-4 (Syn4), a transmembrane proteoglycan, plays an important role in cellular behavior, due to its interaction with the cytoskeleton through the protein core and the extracellular space via…
Mucopolysaccharidosis IIIC (MPS IIIC) is a rare lysosomal disease caused by deficiency of lysosomal enzyme acetyl-CoA:±-glucosaminide N-acetyltransferase (HGSNAT) involved in catabolism of the glycosaminoglycan (GAG) heparan sulfate (HS). Non-degraded HS accumulate in lysosomes in the cells of multiple organs and tissues, causing a progressive and multisystemic pathology. Neurodegeneratio…
| 5 / 5 | Ongoing research grants |
| 25 / 9 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 18 / 5 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 52 / 23 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 31 |
| Citations | 129 |
| Cit./Article | 4.2 |
| Data from Web of Science | |
SIMOES, PRISCILA S. R.; ZANELATTO, ALEXIA O.; ASSIS, MIRIAN C.; VARELLA, PEDRO PAULO V.; YACUBIAN, ELZA MARCIA; CARRETE, HENRIQUE; CENTENO, RICARDO; ARAUJO, MARIANA S.; CAVALHEIRO, ESPER A.; TERSARIOL, IVARNE LUIS S.; et al. Plasma kallikrein-kinin system contributes to peripheral inflammation in temporal lobe epilepsy. Journal of Neurochemistry, v. 150, n. 3, p. 296-311, AUG 2019. Web of Science Citations: 1. (17/22047-0, 13/15179-6, 15/03964-6)
MENDES, ALINE; MENEGHETTI, MARIA C. Z.; PALLADINO, MARCELLY VALLE; JUSTO, GISELLE ZENKER; SASSAKI, GUILHERME L.; FAREED, JAWED; LIMA, MARCELO A.; NADER, HELENA B.. Crude Heparin Preparations Unveil the Presence of Structurally Diverse Oversulfated Contaminants. Molecules, v. 24, n. 16, AUG 2019. Web of Science Citations: 0. (17/14179-3, 15/03964-6)
VIANA, GUSTAVO MONTEIRO; GONZALEZ, ESTEBAN ALBERTO; PALACIO ALVAREZ, MARCELA MACIEL; CAVALHEIRO, RENAN PELLUZZI; DO NASCIMENTO, CINTHIA CASTRO; BALDO, GUILHERME; D'ALMEIDA, VANIA; DE LIMA, MARCELO ANDRADE; PSHEZHETSKY, V, ALEXEY; NADER, HELENA BONCIANI. Cathepsin B-associated Activation of Amyloidogenic Pathway in Murine Mucopolysaccharidosis Type I Brain Cortex. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 21, n. 4, FEB 2020. Web of Science Citations: 0. (17/14179-3, 18/17003-6, 15/03964-6, 16/25486-1)
VICENTE, CAROLINA MELONI; DA SILVA, DAIANA APARECIDA; SARTORIO, PRISCILA VERONICA; SILVA, TIAGO DONIZETTI; SAAD, SARHAN SYDNEY; NADER, HELENA BONCIANI; FORONES, NORA MANOUKIAN; TOMA, LENY. Heparan Sulfate Proteoglycans in Human Colorectal Cancer. ANALYTICAL CELLULAR PATHOLOGY, 2018. Web of Science Citations: 3. (15/03964-6, 16/18066-6)
DE GODOY, CARLOS M. G.; VASQUES, ENIO R.; CARICATI-NETO, AFONSO; TAVARES, JOSE G. P.; ALVES, BEATRIZ J.; DUARTE, JULIANA; MIRANDA-FERREIRA, REGIANE; LIMA, MARCELO A.; NADER, HELENA B.; DOS SANTOS TERSARIOL, IVARNE L.. Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 5, JUN 7 2018. Web of Science Citations: 3. (15/03964-6, 15/08782-3)
DE SOUSA, J. P.; CARVALHO, R. G.; BARBOSA-MARTINS, L. F.; TORQUATO, R. J. S.; MUGNOL, K. C. U.; NASCIMENTO, F. D.; TERSARIOL, I. L. S.; PUPPIN-RONTANI, R. M.. The Self-Assembling Peptide P-11-4 Prevents Collagen Proteolysis in Dentin. JOURNAL OF DENTAL RESEARCH, v. 98, n. 3, p. 347-354, MAR 2019. Web of Science Citations: 1. (13/05822-9, 15/03964-6, 15/12660-0, 14/22899-8)
BEDNASKI, A. V.; TREVISAN-SILVA, D.; MATSUBARA, F. H.; BOIA-FERREIRA, M.; OLIVERIO, M. M.; GREMSKI, L. H.; CAVALHEIRO, R. P.; DE PAULA, D. M. B.; PAREDES-GAMERO, E. J.; TAKAHASHI, H. K.; et al. Characterization of Brown spider (Loxosceles intermedia) hemolymph: Cellular and biochemical analyses. Toxicon, v. 98, p. 62-74, MAY 2015. Web of Science Citations: 3. (06/07005-4)
LUCENA, SHEYLA V.; MOURA, GIOCONDA E. D. D.; RODRIGUES, TIAGO; WATASHI, CAROLINA M.; MELO, FABIANA H.; ICIMOTO, MARCELO Y.; VIANA, GUSTAVO M.; NADER, HELENA B.; MONTEIRO, HUGO P.; TERSARIOL, IVARNE L. S.; et al. Heparan sulfate proteoglycan deficiency up-regulates the intracellular production of nitric oxide in Chinese hamster ovary cell lines. Journal of Cellular Physiology, v. 233, n. 4, p. 3176-3194, APR 2018. Web of Science Citations: 0. (15/03964-6)
GESTEIRA, TARSIS F.; POL-FACHIN, LAERCIO; COULSON-THOMAS, VIVIEN JANE; LIMA, MARCELO A.; VERLI, HUGO; NADER, HELENA B.. Insights into the N-Sulfation Mechanism: Molecular Dynamics Simulations of the N-Sulfotransferase Domain of Ndst1 and Mutants. PLoS One, v. 8, n. 8, AUG 5 2013. Web of Science Citations: 10.
VICENTE, CAROLINA M.; LIMA, MARCELO A.; YATES, EDWIN A.; NADER, HELENA B.; TOMA, LENY. Enhanced Tumorigenic Potential of Colorectal Cancer Cells by Extracellular Sulfatases. MOLECULAR CANCER RESEARCH, v. 13, n. 3, p. 510-523, MAR 2015. Web of Science Citations: 9.
LUCENA, SHEYLA V.; MOURA, GIOCONDA E. D. D.; RODRIGUES, TIAGO; WATASHI, CAROLINA M.; MELO, FABIANA H.; ICIMOTO, MARCELO Y.; VIANA, GUSTAVO M.; NADER, HELENA B.; MONTEIRO, HUGO P.; TERSARIOL, IVARNE L. S.; et al. Heparan sulfate proteoglycan deficiency up-regulates the intracellular production of nitric oxide in Chinese hamster ovary cell lines. Journal of Cellular Physiology, v. 233, n. 4, p. 3176-3194, APR 2018. Web of Science Citations: 0. (15/03964-6)
DE GODOY, CARLOS M. G.; VASQUES, ENIO R.; CARICATI-NETO, AFONSO; TAVARES, JOSE G. P.; ALVES, BEATRIZ J.; DUARTE, JULIANA; MIRANDA-FERREIRA, REGIANE; LIMA, MARCELO A.; NADER, HELENA B.; DOS SANTOS TERSARIOL, IVARNE L.. Heparin Oligosaccharides Have Antiarrhythmic Effect by Accelerating the Sodium-Calcium Exchanger. FRONTIERS IN CARDIOVASCULAR MEDICINE, v. 5, JUN 7 2018. Web of Science Citations: 3. (15/08782-3, 15/03964-6)
RIBEIRO-FILHO, ANTONIO CARLOS; BURI, MARCUS VINICIUS; BARROS, CARLOS CASTILHO; DREYFUSS, JULIANA LUPORINI; NADER, HELENA BONCIANI; JUSTO, GISELLE ZENKER; CRAVEIRO, ROGERIO BASTOS; PESQUERO, JOAO BOSCO; MIRANDA, ANTONIO; FERREIRA, ALICE TEIXEIRA; et al. Functional and molecular evidence for heteromeric association of P2Y(1) receptor with P2Y(2) and P2Y(4) receptors in mouse granulocytes. BMC PHARMACOLOGY & TOXICOLOGY, v. 17, JUL 7 2016. Web of Science Citations: 1. (13/09068-7, 15/16799-3)
DO NASCIMENTO, CINTHIA CASTRO; AGUIAR, ODAIR; VIANA, GUSTAVO MONTEIRO; D'ALMEIDA, VANIA. Morphological damage in Sertoli, myoid and interstitial cells in a mouse model of mucopolysaccharidosis type I (MPS I). MOLECULAR BIOLOGY REPORTS, v. 48, n. 1, DEC 2020. Web of Science Citations: 0. (16/25486-1)
ESTEVES, GABRIELA NOHEMI NUNEZ; FERRAZ, LETICIA SILVA; ALVAREZ, MARCELA MACIEL PALACIO; DA COSTA, CLAUDIA ALVES; LOPES, RAYSSA DE MELLO; TERSARIOL, IVARNE LUIS DOS SANTOS; RODRIGUES, TIAGO. BRAF and NRAS mutated melanoma: Different Ca2+ responses, Na+/Ca2+ exchanger expression, and sensitivity to inhibitors. Cell Calcium, v. 90, SEP 2020. Web of Science Citations: 0. (18/25747-5, 16/07367-5, 15/03964-6)
PALHARES, LAIS C. G. F.; BRITO, ADRIANA S.; DE LIMA, MARCELO A.; NADER, HELENA B.; LONDON, JAMES A.; BARSUKOV, IGOR L.; ANDRADE, GIULIANNA P. V.; YATES, EDWIN A.; CHAVANTE, SUELY F.. A further unique chondroitin sulfate from the shrimp Litopenaeus vannamei with antithrombin activity that modulates acute inflammation. Carbohydrate Polymers, v. 222, OCT 15 2019. Web of Science Citations: 0. (17/14179-3, 15/03964-6)
SIMOES, PRISCILA S. R.; ZANELATTO, ALEXIA O.; ASSIS, MIRIAN C.; VARELLA, PEDRO PAULO V.; YACUBIAN, ELZA MARCIA; CARRETE, HENRIQUE; CENTENO, RICARDO; ARAUJO, MARIANA S.; CAVALHEIRO, ESPER A.; TERSARIOL, IVARNE LUIS S.; et al. Plasma kallikrein-kinin system contributes to peripheral inflammation in temporal lobe epilepsy. Journal of Neurochemistry, JULY 2019. Web of Science Citations: 0. (15/03964-6, 13/15179-6, 17/22047-0)
PAREDES-GAMERO, EDGAR J.; MEDEIROS, VALQUIRIA P.; FARIAS, EDUARDO H. C.; JUSTO, GISELLE Z.; TRINDADE, EDVALDO S.; ANDRADE-LOPES, ANA L.; GODINHO, ROSELY O.; DE MIRANDA, ANTONIO; FERREIRA, ALICE T.; TERSARIOL, IVARNE L. S.; et al. Heparin Induces Rat Aorta Relaxation via Integrin-Dependent Activation of Muscarinic M-3 Receptors. Hypertension, v. 56, n. 4, p. 713-U282, OCT 2010. Web of Science Citations: 18.
MOTTA, GUACYARA; TERSARIOL, IVARNE L. S.. Modulation of the Plasma Kallikrein-Kinin System Proteins Performed by Heparan Sulfate Proteoglycans. FRONTIERS IN PHYSIOLOGY, v. 8, JUL 11 2017. Web of Science Citations: 5. (15/03964-6, 16/14827-2)
SOUSA ONYEISI, JESSICA OYIE; DE ALMEIDA PERNAMBUCO FILHO, PAULO CASTANHO; LOPES, SILVANA DEARAUJO; NADER, HELENA BONCIANI; LOPES, CARLA CRISTINA. Heparan sulfate proteoglycans as trastuzumab targets in anoikis-resistant endothelial cells. Journal of Cellular Biochemistry, v. 120, n. 8, p. 13826-13840, AUG 2019. Web of Science Citations: 0. (15/22546-0, 15/03964-6)
ALVAREZ, M. M. P.; MOURA, G. E.; MACHADO, M. F. M.; VIANA, G. M.; DE SOUZA COSTA, C. A.; TJADERHANE, L.; NADER, H. B.; TERSARIOL, I. L. S.; NASCIMENTO, F. D.. PAR-1 and PAR-2 Expression Is Enhanced in Inflamed Odontoblast Cells. JOURNAL OF DENTAL RESEARCH, v. 96, n. 13, p. 1518-1525, DEC 2017. Web of Science Citations: 1. (15/03964-6, 13/05822-9)
CAVALHEIRO, R. P.; LIMA, M. A.; JARROUGE-BOUCAS, T. R.; VIANA, G. M.; LOPES, C. C.; COULSON-THOMAS, V. J.; DREYFUSS, J. L.; YATES, E. A.; TERSARIOL, I. L. S.; NADER, H. B.. Coupling of vinculin to F-actin demands Syndecan-4 proteoglycan. MATRIX BIOLOGY, v. 63, p. 23-37, NOV 2017. Web of Science Citations: 7. (15/03964-6, 15/08782-3)
RODRIGUES, TIAGO; NUNEZ ESTEVEZ, GABRIELA NOHEMI; DOS SANTOS TERSARIOL, IVARNE LUIS. Na+/Ca2+ exchangers: Unexploited opportunities for cancer therapy?. Biochemical Pharmacology, v. 163, p. 357-361, MAY 2019. Web of Science Citations: 1. (15/03964-6, 16/07367-5)
PERES, GIOVANI B.; SCHOR, NESTOR; MICHELACCI, YARA M.. Impact of high glucose and AGEs on cultured kidney-derived cells. Effects on cell viability, lysosomal enzymes and effectors of cell signaling pathways. Biochimie, v. 135, p. 137-148, APR 2017. Web of Science Citations: 4. (15/03964-6, 13/07109-8, 10/16022-5)
CHAVANTE, SUELY F.; BRITO, ADRIANA S.; LIMA, MARCELO; YATES, EDWIN; NADER, HELENA; GUERRINI, MARCO; TORRI, GIANGIACOMO; BISIO, ANTONELLA. A heparin-like glycosaminoglycan from shrimp containing high levels of 3-O-sulfated D-glucosamine groups in an unusual trisaccharide sequence. Carbohydrate Research, v. 390, p. 59-66, MAY 22 2014. Web of Science Citations: 14. (12/00850-1)
COULSON-THOMAS, VIVIEN J.; COULSON-THOMAS, YVETTE M.; GESTEIRA, TARSIS F.; ANDRADE DE PAULA, CLAUDIA A.; CARNEIRO, CELIA R. W.; ORTIZ, VALDEMAR; TOMA, LENY; KAO, WINSTON W. -Y.; NADER, HELENA B.. Lumican expression, localization and antitumor activity in prostate cancer. Experimental Cell Research, v. 319, n. 7, p. 967-981, APR 15 2013. Web of Science Citations: 33.
PAREDES-GAMERO, EDGAR J.; MEDEIROS, VALQUIRIA P.; LIMA, MARCELO A.; ACCARDO, CAMILA M.; FARIAS, EDUARDO H. C.; SASSAKI, GUILHERME I.; CAMPANA, PATRICIA T.; MIRANDA, ANTONIO; FERREIRA, ALICE T.; TERSARIOL, IVARNE L. S.; et al. Chemical reduction of carboxyl groups in heparin abolishes its vasodilatory activity. Journal of Cellular Biochemistry, v. 113, n. 4, p. 1359-1367, APR 2012. Web of Science Citations: 6.
VICENTE, CAROLINA M.; LIMA, MARCELO A.; NADER, HELENA B.; TOMA, LENY. SULF2 overexpression positively regulates tumorigenicity of human prostate cancer cells. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, v. 34, MAR 14 2015. Web of Science Citations: 9.
RODRIGUES-JUNIOR, DORIVAL MENDES; DE ANDRADE PELARIN, MARIA FERNANDA; NADER, HELENA BONCIANI; VETTORE, ANDRE LUIZ; SILVA PINHAL, MARIA APARECIDA. MicroRNA-1252-5p Associated with Extracellular Vesicles Enhances Bortezomib Sensitivity in Multiple Myeloma Cells by Targeting Heparanase. ONCOTARGETS AND THERAPY, v. 14, p. 455-467, 2021. Web of Science Citations: 0. (15/09182-0, 16/01357-8, 15/03964-6)
MENEGHETTI, MARIA C. Z.; DEBONI, PAULA; PALOMINO, CARLOS M. V.; BRAGA, LUIZ P.; CAVALHEIRO, RENAN P.; VIANA, GUSTAVO M.; YATES, EDWIN A.; NADER, HELENA B.; LIMA, MARCELO A.. ER-Golgi dynamics of HS-modifying enzymes via vesicular trafficking is a critical prerequisite for the delineation of HS biosynthesis. Carbohydrate Polymers, v. 255, MAR 1 2021. Web of Science Citations: 0. (17/14179-3, 15/03964-6)
DO NASCIMENTO, CINTHIA CASTRO; AGUIAR, ODAIR; VIANA, GUSTAVO MONTEIRO; D'ALMEIDA, VANIA. Morphological damage in Sertoli, myoid and interstitial cells in a mouse model of mucopolysaccharidosis type I (MPS I). MOLECULAR BIOLOGY REPORTS, v. 48, n. 1, DEC 2020. Web of Science Citations: 0. (16/25486-1)
(References retrieved automatically from State of São Paulo Research Institutions)
TRINDADE, Edvaldo da Silva. Papel da matriz extracelular no estímulo da síntese do heparam sulfato antitrombótico promovido pela heparina em células endoteliais. 181 f. Tese (Doutorado) - Escola Paulista de Medicina. Universidade Federal de São Paulo (UNIFESP). São Paulo. (99/12955-6)