graduate at Ciencias Biologicas Modalidade Medica from Universidade Federal de São Paulo (1970), graduate at Biologia from Universidade de São Paulo (1971) and ph.d. at Biochemistry from Universidade Federal de São Paulo (1974). Has experience in Biochemistry, focusing on Chemistry of Macromolecules, acting on the following subjects: heparina, heparam sulfato, heparin, glicosaminoglicanos and heparam. (Source: Lattes Curriculum)
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Among the rare diseases, mucopolysaccharidoses I and II (MPS I and II) are particularly common in the states of São Paulo and Rio Grande do Sul and are caused by mutations in genes encoding lysosomal proteins (enzymes). The currently available treatments are not curative and are particularly inefficient for the prevention of neurological symptoms. In addition, they cost millions of dollar…
The glycoconjugates, including glycosaminoglycans (GAGs), belong to the most abundant class of structurally diverse and heterogeneous molecules present in the extracellular matrix and on the cell surface. Unlike nucleic acids and proteins, the information necessary for their biosynthesis does not have a known code. The diverse and heterogeneous structures are the result of the action of g…
Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the new SARS-CoV-2 coronavirus outbreak. Traditional drug development processes are slow and ineffective against such emerging public health threats. Repurposing existing drugs that are capable of preventing and treating novel coronavirus infections is a timely and…
The project "70 years of the Brazilian Society for the Progress of Science (SBPC), Past & Present designing the Future" focus on the work of the Society with impact in the policies of science, education, innovation, health and environment. SBPC is a unique Society in Latin American, in continuous activity since 1948. The research product will be a book base in historical process of the So…
(Only some records are available in English at this moment)
The glycoconjugates, including glycosaminoglycans (GAGs), belong to the most abundant class of structurally diverse and heterogeneous molecules present in the extracellular matrix and on the cell surface. Unlike nucleic acids and proteins, the information necessary for their biosynthesis does not have a known code. The diverse and heterogeneous structures are the result of the action of g…
Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the new SARS-CoV-2 Coronavirus outbreak. Traditional drug development processes are slow and ineffective against such emerging public health threats. Repurposing existing drugs that are capable of preventing and treating novel Coronavirus infections is a timely and…
It has been assumed that the biosynthesis of Heparan Sulfate ((HS) occurs through a hierarchical sequence of enzymatic events, involving polymerization, sulfation and epimerization, and the 3-O-sulfotransferase (HS3ST) is the last enzyme in this sequence of events. However, we have recently shown that HS3ST can act at different stages of HS biosynthesis and besides enzyme specificity, oth…
(Only some records are available in English at this moment)
Glycoconjugates, including proteoglycans, belong to the most abundant class of structurally diverse and heterogeneous molecules present in the extracellular matrix (ECM) and on the cell surface. Syndecan-4 (Syn4), a transmembrane proteoglycan, plays an important role in cellular behavior, due to its interaction with the cytoskeleton through the protein core and the extracellular space via…
Mucopolysaccharidosis IIIC (MPS IIIC) is a rare lysosomal disease caused by deficiency of lysosomal enzyme acetyl-CoA:±-glucosaminide N-acetyltransferase (HGSNAT) involved in catabolism of the glycosaminoglycan (GAG) heparan sulfate (HS). Non-degraded HS accumulate in lysosomes in the cells of multiple organs and tissues, causing a progressive and multisystemic pathology. Neurodegeneratio…
| 2 / 2 | Ongoing research grants |
| 29 / 13 | Completed research grants |
| 21 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 54 / 25 | All research grants and scholarships |
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CV Lattes
ORCID