CV Lattes
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Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. Escola Paulista de Medicina (EPM) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Ciencias Biologicas Modalidade Medica from Universidade Federal de São Paulo (1970), graduate at Biologia from Universidade de São Paulo (1971) and ph.d. at Biochemistry from Universidade Federal de São Paulo (1974). Has experience in Biochemistry, focusing on Chemistry of Macromolecules, acting on the following subjects: heparina, heparam sulfato, heparin, glicosaminoglicanos and heparam. (Source: Lattes Curriculum)
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The extracellular matrix (ECM) is constantly remodeling in response to various extracellular and intracellular stimuli, and the way in which these signals are transmitted, captured and interpreted by cells, determines and differentiates the fate of normal or pathological remodeling. Response to stimuli is a hallmark of the definition of life. Communication between cells is essential and i…
The extracellular matrix (ECM) is constantly remodeling in response to various extracellular and intracellular stimuli, and the way in which these signals are transmitted, captured and interpreted by cells, determines and differentiates the fate of normal or pathological remodeling. Response to stimuli is a hallmark of the definition of life. Communication between cells is essential and i…
The extracellular matrix (ECM) is constantly remodeling in response to various extracellular and intracellular stimuli, and the way in which these signals are transmitted, captured and interpreted by cells, determines and differentiates the fate of normal or pathological remodeling. Response to stimuli is a hallmark of the definition of life. Communication between cells is essential and i…
(Only some records are available in English at this moment)
Among the rare diseases, mucopolysaccharidoses I and II (MPS I and II) are particularly common in the states of São Paulo and Rio Grande do Sul and are caused by mutations in genes encoding lysosomal proteins (enzymes). The currently available treatments are not curative and are particularly inefficient for the prevention of neurological symptoms. In addition, they cost millions of dollar…
Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the new SARS-CoV-2 coronavirus outbreak. Traditional drug development processes are slow and ineffective against such emerging public health threats. Repurposing existing drugs that are capable of preventing and treating novel coronavirus infections is a timely and…
The project "70 years of the Brazilian Society for the Progress of Science (SBPC), Past & Present designing the Future" focus on the work of the Society with impact in the policies of science, education, innovation, health and environment. SBPC is a unique Society in Latin American, in continuous activity since 1948. The research product will be a book base in historical process of the So…
(Only some records are available in English at this moment)
The project seeks to understand how heparin interacts with antithrombin, an essential protein in the coagulation process, and how this interaction influences its ability to inhibit angiogenic processes, such as the formation of new blood vessels. Studies suggest that chemical modification of heparin may alter antithrombin's antiangiogenic activity, offering a potential therapeutic approac…
Syndecan-4 (Syn4) is a heparan sulfate proteoglycan extensively involved in cell-extracellular matrix (ECM) communication and ECM remodeling. This study aims to investigate the role of Syn4 in cellular trafficking and molecular regulation of ECM, utilizing genetically modified cell models. The research will address mechanisms influencing cell adhesion, migration, and associated signaling …
Objective: This project aims to investigate the anti-angiogenic effects of chemically modified heparins, specifically 6-desulfated heparin, in combination with bevacizumab, an anti-VEGF monoclonal antibody. The study will be conducted on human endothelial cells, specifically the ECV304 cell line, which is widely used in angiogenesis research due to its representative characteristics of en…
(Only some records are available in English at this moment)
The present project aims to better understand the role played by syndecan-4 invascular biology involving cell signaling pathways related to migration processes. cellproliferation and adhesion. The behavior of wild-type endothelial cells and endothelialcells that do not express syndecan-4 and that overexpress this proteoglycan whenfaced with stimuli using different preparations of heparin …
The glycoconjugates, including glycosaminoglycans (GAGs), belong to the most abundant class of structurally diverse and heterogeneous molecules present in the extracellular matrix and on the cell surface. Unlike nucleic acids and proteins, the information necessary for their biosynthesis does not have a known code. The diverse and heterogeneous structures are the result of the action of g…
Currently, there are no commercially available medicinal products designed to treat and/or prevent infections associated with the new SARS-CoV-2 Coronavirus outbreak. Traditional drug development processes are slow and ineffective against such emerging public health threats. Repurposing existing drugs that are capable of preventing and treating novel Coronavirus infections is a timely and…
(Only some records are available in English at this moment)
Glycoconjugates, including proteoglycans, belong to the most abundant class of structurally diverse and heterogeneous molecules present in the extracellular matrix (ECM) and on the cell surface. Syndecan-4 (Syn4), a transmembrane proteoglycan, plays an important role in cellular behavior, due to its interaction with the cytoskeleton through the protein core and the extracellular space via…
Mucopolysaccharidosis IIIC (MPS IIIC) is a rare lysosomal disease caused by deficiency of lysosomal enzyme acetyl-CoA:±-glucosaminide N-acetyltransferase (HGSNAT) involved in catabolism of the glycosaminoglycan (GAG) heparan sulfate (HS). Non-degraded HS accumulate in lysosomes in the cells of multiple organs and tissues, causing a progressive and multisystemic pathology. Neurodegeneratio…
| 4 / 4 | Ongoing grants |
| 29 / 13 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 22 / 9 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 62 / 33 | All research grants and scholarships |
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