Luciana Politti Cartarozzi

• Abstract

  Peripheral nerve lesions are followed by an increase in expression of immune molecules, such as the Major Histocompatibility Complex Class I (MHC-I). The MHC-I upregulation is directly related to the synaptic plasticity process, glial cell activity modulation and functional recovery. Knockout mice for the MHC-I obligatory chain ²2 microglobulin (²2m), show increased reduction in synaptic …

  Involvement of MHC I, TLR2 and TLR4 in the synaptic plasticity and functional reovery following crushing of spinal ventral roots in mice, BP.PD

• Abstract

  The interaction between motoneurons and the circunjacent microenvironment has a crucial function for survival and regulation of functional state and synaptic connectivity. After trauma, indicative changes of dysfunction and degeneration initiate proximal and distal to lesion, however, the regenerative capacity of nervous system result in compensatory structural and functional remodeling o…

  Immunomodulatory mechanisms of mesenchymal stem cells in glial reactivity and correlation with nervous system regenerative capacity after lumbar root axotomy, BP.DR
• Use of fibrin sealant combined with mesenchymal stem cells in the repair of peripheral nerves through tubulization technique, BP.MS

(Only some records are available in English at this moment)

• Abstract

  The interaction between motoneurons and glial cells has a crucial role for survival, regulation of functional state and synaptic connectivity in the spinal cord. Understanding the basic functions of glial cells and motoneuron interaction will contribute to the development of new strategies in order to promote regeneration after injury. After lesion, glial cells also undergo a series of mo…

  Analysis of MHC class I-dependent reactivity of glial cell after nervous system lesions by in vivo two-photon imaging, BE.EP.DR

• Abstract

  For analysis of the progression of regeneration in the central and peripheral nervous system usually are used techniques from histological sections that provide a two-dimensional image of the regenerating axons, showing only fragments, and may thus lead to misinterpretations. In order to overcome this obstacle, the tetrahydrofuran (THF)-based clearing technique was proposed. Through this …

  Analysis of cellular mechanisms of acute injuries in the central and peripheral nervous system using novel imaging approaches, BE.EP.MS