CV Lattes
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Universidade de São Paulo (USP). Instituto de Ciências Biomédicas (ICB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Graduated in Pharmacy-Biochemistry from the University of São Paulo (1986), Master's degree in Psychobiology from the Federal University of São Paulo (1992), and Ph.D. in Psychobiology from the Federal University of São Paulo (1997). Postdoctoral at the Ernest Gallo Clinic and Research Center, University of California, San Francisco. Associate Professor in the Department of Pharmacology at the Institute of Biomedical Sciences, University of São Paulo, and Head of the Pharmacology Department at ICB-USP since 2021 (Vice-Head from 2018-2021). President of the International Society of Biomedical Research on Alcoholism - ISBRA (2020-2022) and President of the Latin American Society of Biomedical Research on Alcoholism - LASBRA (2008-2013). In 2014, I was elected as a member of the Board of Directors of the International Society of Biomedical Research on Alcoholism - ISBRA, and in 2016, elected as the Junior Vice President of ISBRA (2016-2018), and Senior Vice President of ISBRA (2018-2020). Coordinator of the Coordinating Committee of the Graduate Program (CCP) in the Department of Pharmacology at ICB-USP from 2013 to 2017. Experience in the field of Neuropsychopharmacology, with a focus on the effects of ethanol and cocaine during neurodevelopment, effects of environmental manipulations (enrichment/stress) in animal models of substance use disorders (SUDs), and effects of environmental manipulations in patients with SUDs. (Source: Lattes Curriculum)
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Alcohol dependence syndrome makes up an important part of the burden attributable to alcohol consumption, resulting not only in an increase in the number of deaths, but also in years lived with disability, both deleterious to the individual's life, public health and development. economic status of the population. This drives the search for biomarkers that can increase the understanding of…
Alcohol consumption by pregnant women is a serious public health issue. Besides the harm it can cause to the mother, alcohol can cross the placental barrier and affect fetal development. Alcohol exposure can result in direct effects on the fetus, and its consumption during pregnancy can also interfere with the bond between the mother and the offspring, possibly reducing maternal oxytocin …
Alcohol consumption during pregnancy is a serious public health problem, given that the drug cross the placental barrier and affect embryo-fetal development. In addition to the direct effects of exposure to alcohol on the fetus, consumption during pregnancy can also interfere with the care that the mother expresses with the offspring, as the drug seems to interrupt the interaction between…
Environmental conditions exert a great influence on the behavioral and neurochemical effects induced by drugs of abuse. Stress plays an important role in the development of dependence, as well as in relapse. On the other hand, the exposure of rodents to stimuli such as toys, exercise wheels and fellowship with other individuals, a model known as environmental enrichment (EA), is capable o…
Environmental enrichment (EE) allows to study the influence of the environment in response to various manipulations, including the treatment of drug abuse. Our laboratory has shown that the EE is able to prevent and reverse the behavioral sensitization to ethanol in mice, and this was accompanied by decreased of Brain Derived Neurotrophic Factor (BDNF) in the prefrontal cortex of animals.…
(Only some records are available in English at this moment)
Anatomical studies highlight the relevance of the periaqueductal gray (PAG) in reward processing due to its connections with circuits mediating these behaviors. The lateral PAG (lPAG) is strategically positioned to influence reward-seeking behavior, while the ventrolateral PAG (vlPAG), with glutamatergic projections to the Ventral Tegmental Area (VTA), is implicated in processing environm…
Psychoactive substances, such as ethanol, have the ability to activate the reward system (RS). Preliminary results from our laboratory indicate that the periaqueductal gray matter (PAG) is part of this system. Exposure to ethanol can affect the sensitivity to natural rewarding stimuli and maternal behavior (MB). Reward refers to a positive reinforcement after performing a behavior. Regard…
Alcohol dependence syndrome makes up an important part of the burden attributable to alcohol consumption, resulting not only in an increase in the number of deaths, but also in years lived with disability, both deleterious to the individual's life, public health and development. economic status of the population. This drives the search for biomarkers that can increase the understanding of…
(Only some records are available in English at this moment)
Substance use disorder is a complex disease, influenced by genetic, environmental, and social factors (Kendler, 2001), and is characterized by the compulsive use of a drug, loss of control over its administration, and persistent use despite its negative effects (Koob, 2008). Oxytocin (OT) is a pro-social peptide that has been increasingly described as a protector against drug addiction. S…
It has been recently shown that the environmental conditions to which the sire is exposed may affect its offspring's phenotype, the so called Transgenerational Epigenetic Inheritance (TEI). Despite its mechanisms are unknown, changes in the miRNA expression profile may be an explanation for the phenomenon since miRNA expression changes promoted by the environment are capable of altering t…
Alcohol consumption during gestation is common and constitutes a serious public health problem, as the alcohol overcomes the placental barrier, which may affect the embryo-fetal development. In addition to the direct effects of alcohol exposure on the fetus, the excessive consumption during gestation may also interfere with the maternal care towards the offspring, since the drug appear to…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 12 / 8 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 11 / 9 | Completed scholarships in Brazil |
| 1 / 0 | Completed scholarships abroad |
| 30 / 23 | All research grants and scholarships |
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