CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Sérvia
Ljubica Tasic is a chemist, holds a PhD (2002), and leads a biological chemistry group at the Organic Chemistry Department of the Institute of Chemistry, University of Campinas, Campinas, Sao Paulo, Brazil (2004). She is a full professor (2024). Her research projects are related to biochemistry, bionanotechnology, and metabolomics. She studies the chemistry and biochemistry of diseases using bioanalytical, biophysics, and biochemistry techniques. She seeks information about the composition of mixtures or structures of different biomolecules to understand how biological systems change. She aims to understand the molecular bases of various diseases, emphasizing human health problems. Our research interests in metabolomics are divided into three main fields: (i) the use of advanced analytical tools such as NMR-based metabolomics in the investigation of clinical and animal model samples; (ii) studying the mechanisms of the alterations provoked because of the disease and some drug use trough effects on metabolites, and (iii) human biomonitoring studies. Ljubica's research team has been evaluating various human diseases, such as mental health disorders, illicit drug use (crack), cancer in children and adults, and others using semi-solid and liquid NMR techniques.In bionanotechnology, she explores the wide use of metal and metal-oxide nanoparticles, such as silver nanoparticles (AgNPs), and uses biogenic routes for their synthesis. Our research group also produces new materials and compounds with biological activities from agro-industrial waste.We can also mention projects under development with the Brazilian industry, one in the pilot scale phase, Orange Biorefinery, which aimed to use orange pomace to produce materials such as hesperitin, pectin, lignin, and cellulose nanofibers, in a sequential extraction process idealized, designed and developed by our group.She has authored or co-authored over 135 peer-reviewed publications in journals of chemistry, nanotechnology, and bionanotechnology, with around 3,700 citations, (h 32). Also, she has organized one book, published over 25 book chapters, and deposited 9 patents (Brazilian Agency), two (2) conceived recently. For around 20 years as a professor at UNICAMP, she has mentored and supervised, providing advice, training, and career development opportunities to PhD students (12), MSc degree students (17), post-docs (15), and under-graduation research projects (more than 65). (Source: Lattes Curriculum)
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| Academia-business partnership stimulates local production of inputs for key COVID-19 diagnostic test |
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Prosthesis-related stomatitis or Denture Stomatitis, is an inflammatory reaction that occurs among other factors, mainly due to a fungal infection by Candida albicans and NCA (non-albicans Candida) in the oral tissues in patients with complete dentures or removable partial dentures. The majority of users of prosthetic devices develop this pathology, which is associated with the aging of t…
The proposal to create the Center for Thromboembolic Diseases (CDT) fits within FAPESP's call for Science Centers for Development since it deals with an important public health issue, with a great social and economic. This center will contribute to obtaining access to epidemiological and cost-effective data on treatments, helping in public policy. An important tool, the development of an …
The interior of organisms constitute complex, crowded and dynamic environments with little semblance to the experiments conducted on isolated proteins. Data on the possible interactions that specific proteins can participate in within these crowded physiological environments is fundamental to understanding the multiple roles that are frequently played by proteins. High-resolution structur…
(Only some records are available in English at this moment)
The present project aims at metabolomic and metabonomic analyzes by nuclear magnetic resonance techniques applied to studies of childhood and juvenile cancers and glioma (glioblastoma). Information about metabolic changes in cancer cells is known and studied, but studies in younger populations - among children and adolescents aged 1 to 19 years - are scarce because they present a group of…
The metabolomics is the newest "omics" platform applied in chemical and biochemical studies of organisms, which enables the detection of specific metabolic changes caused by disease states or by pharmacological and/or therapeutic interventions. Although psychiatric illnesses such as schizophrenia and bipolar disorder have been associated with metabolic changes, metabolomics studies in the…
The exposome covers all exposures an individual is subjected to from conception to death. This work aims to identify metabolic profiles of populations submitted to various types of exposures, relating to the increase of health risks and regional differences. Metabolomic andmetabolomic analyses based on serum and urine NMR and subsequent application of multivariate statistical analysis tec…
The project involves the development of a multilayer approach to identify protein exositesusing data compilation and neural network training. A pipeline will be developed to identify potential protein partners using phage display experiments and co-localization information. The use of MRND will help identify protein-protein partners that interact at exosite loci. The project will also inv…
Citrus sinensis (L.) Osbeck, one of the most important fruits in the world, presents itself as an important species used for processing and production of orange juice, a procedure that generates a significant amount of citrus peel waste. This biomass is an enriched source of a wide variety of compounds, such as flavonoids, essential oils, vitamins, organic acids, fibers, pectin, proteins…
Citrus fruits are the most consumed and processed fruits worldwide, especially oranges, which have the majority of their production destined for juice production, generating a large amount of waste. This biomass generated from orange processing is abundant in chemical compounds such as proteins, starch, soluble sugars, lipids, lignin, pectin, and cellulose, which have high added value in …
The exposome covers all exposures to which an individual is subjected from conception to death. The objective of this work is to identify metabolic profiles of populations submitted to various types of exposures, relating to the increase of health risks and regional differences. Metabolomic and metabonomic analyzes based on serum and urine NMR and subsequent application of multivariate st…
(Only some records are available in English at this moment)
Corynebacterium pseudotuberculosis (C. pseudotuberculosis) is a Gram-positive bacterium with pathogenic potential in both animals and humans. This facultative intracellular parasite is the etiological agent of caseous lymphadenitis (CLA) in sheep and goats (biovar ovis) and, to a lesser extent, in horses and cattle (biovar equi). Infection by C. pseudotuberculosis in sheep and goats resul…
Terpenes are the most abundant class of natural products in nature. These metabolites have a variety of applications, including pharmaceuticals, perfumes and flavors, bulk chemicals and fuels.This class of natural products is structurally diverse and derived from C5 precursor molecules, isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP). These precursor molecules are…
The metabolism of phospholipids have been related to many neurological disorders. This relation is because the nervous system has the second highest levels of lipids in human body, emphasizing the importance of the role of metabolism lipid. Nowadays, the therapeutic for this diseases are made by psychotropic drugs and is believed that the efficiency is influenced by the level of polyunsat…
| 5 / 5 | Ongoing grants |
| 7 / 3 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 19 / 14 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 2 | Completed scholarships abroad |
| 37 / 28 | All research grants and scholarships |
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