CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
B.Sc. degree in Pharmacy-Biochemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1983), M.Sc. (1991) and Ph.D. (1994) in Molecular Biology-Protein Chemistry from Universidade Federal de São Paulo. Since 1987 she is a Research Scientist at Butantan Institute, São Paulo, Brazil. Research experience in Biochemistry, with focus on the following subjects: snake venoms; metalloproteinases; serine proteinases; proteomic analysis of snake venoms and of the effects of toxins upon cultured cells and tissues. (Source: Lattes Curriculum)
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Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan Institute historically built its strong international reputation. Indeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
Animal venoms comprise many toxins that act in concert to break apart the highly robust homeostatic systems of prey organisms. On the other hand, prey organisms actively antagonize each step of the envenomation phenomenon, which displays a complex kinetics involving important changes at molecular, cell, tissue and organism levels. The challenges for studying venoms and envenomation compre…
The comprehensive knowledge of venom proteome complexity of Bothrops species is important because these snakes cause most accidents in Brazil. Besides ecological and taxonomical implications, knowledge of the natural history and toxin composition of venoms is of fundamental importance for the treatment of envenomation and in the selection of specimens for the preparation of venom pools fo…
The pharmacological activities displayed by Bothrops jararaca venom undergo a significant ontogenetic shift. Likewise, the diet of this species changes from ectothermic prey in early life to endothermic prey in adulthood. In this study we used large and representative newborn and adult venom samples consisted of pools from 694 and 110 specimens, respectively, and demonstrate a significant…
(Only some records are available in English at this moment)
Envenoming by Viperid snakes is a critical public health problem in Brazil and is recognized by the World Health Organization (WHO) as one of the most important Neglected Tropical Diseases, causing a high percentage of permanent disability and, frequently, death. It is well established that systemic effects of envenomation by Bothrops snakes comprise hemorrhage, coagulopathy, shock, and r…
Snakebite envenomation is recognized in category A of the Neglected Tropical Diseases by the World Health Organization (WHO) due to the worldwide burden of snakebite death and disability. Although the local effects of bites are well documented, knowledge on the systemic effects of snake venoms is limited. Envenomation by Viperidae snakes causes hypotension, ultimately leading to shock, co…
Bothrops snake venoms are composed of several families of protein toxins, in addition to bioactive peptides. In Brazil, Bothrops snakes are responsible for more than 90% of cases of accidents, in which the clinical symptoms observed after the bite include local and systemic effects, with the presence of edema, hemorrhage, necrosis, severe coagulopathy, and kidney failure. Therefore, to be…
The Bothrops genus is the main cause of snakebite accidents with envenomation in Brazil, and the venoms of these snakes cause severe local and systemic effects, due to the high concentration of different enzymes, including proteases and phospholipases A2. At the site of bite, tissue damage is an immense concern, as connective tissue and skin cells come into direct contact with toxins. The…
(Only some records are available in English at this moment)
Snake envenomation is classified by the WHO as a neglected tropical disease, which claims millions of victims annually around the world. In Brazil, Bothrops snakes are responsible for more than 90% of snakebites, causing local and systemic pathological effects in the envenomation process. Damage at the site of the bite is primarily characterized by edema, hemorrhage, and myonecrosis, in a…
Snakebite envenomation is recognized in category A of the Neglected Tropical Diseases by the World Health Organization (WHO) due to the worldwide burden of snakebite death and disability. Although the local effects of bites are well documented, knowledge on the systemic effects of snake venoms is limited. Envenomation by Viperidae snakes causes hypotension, ultimately leading to shock, co…
Protein glycosylation is one of the major post-translational modifications (PTMs) in viperid snake venoms, and contributes to diversification of proteomes. We have shown that Bothrops venoms are markedly defined by their content of glycoproteins, and that most N-glycan structures present in eight Bothrops venoms contain sialic acid units. To further investigate proteome venom variation an…
Snake venoms are a rich source of molecules with biological activity, most of which are proteins. The presence of post-translational modification (PTM) in these proteins, such as glycosylation, has been evidenced in many studies. However, the full characterization of this PTM is still poorly known, regardless of its importance. Mass spectrometry is the primary technique for protein glycos…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 10 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 28 / 20 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 8 / 7 | Completed scholarships abroad |
| 51 / 38 | All research grants and scholarships |
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