CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Instituto Butantan (Institutional affiliation from the last research proposal) Birthplace: Brazil
B.Sc. degree in Pharmacy-Biochemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1983), M.Sc. (1991) and Ph.D. (1994) in Molecular Biology-Protein Chemistry from Universidade Federal de São Paulo. Since 1987 she is a Research Scientist at Butantan Institute, São Paulo, Brazil. Research experience in Biochemistry, with focus on the following subjects: snake venoms; metalloproteinases; serine proteinases; proteomic analysis of snake venoms and of the effects of toxins upon cultured cells and tissues. (Source: Lattes Curriculum)
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Animal venoms comprise many toxins that act in concert to break apart the highly robust homeostatic systems of prey organisms. On the other hand, prey organisms actively antagonize each step of the envenomation phenomenon, which displays a complex kinetics involving important changes at molecular, cell, tissue and organism levels. The challenges for studying venoms and envenomation compre…
Toxinology and regulation of the lmmune-response are two interconnected classical areas of scientific investigation around which the Butantan Institute historically built its strong international reputation. Indeed, it is deeply rooted in the culture of Butantan lnstitute, the notion that toxins are components in complex venoms, which were selected by evolution to exert concerted systemic…
The comprehensive knowledge of venom proteome complexity of Bothrops species is important because these snakes cause most accidents in Brazil. Besides ecological and taxonomical implications, knowledge of the natural history and toxin composition of venoms is of fundamental importance for the treatment of envenomation and in the selection of specimens for the preparation of venom pools fo…
The pharmacological activities displayed by Bothrops jararaca venom undergo a significant ontogenetic shift. Likewise, the diet of this species changes from ectothermic prey in early life to endothermic prey in adulthood. In this study we used large and representative newborn and adult venom samples consisted of pools from 694 and 110 specimens, respectively, and demonstrate a significant…
The aim of the Interinstitutional Center for Applied Toxinology is to establish a world-class center for research into natural toxins. The Center will develop the study of toxins with the aim to investigate their potential therapeutic use, to foster contacts between science and industry and to raise the level of scientific human resources. The Institute Butantan with its history and tradi…
(Only some records are available in English at this moment)
The Bothrops genus is the main cause of snakebite accidents with envenomation in Brazil, and the venoms of these snakes cause severe local and systemic effects, due to the high concentration of different enzymes, including proteases and phospholipases A2. At the site of bite, tissue damage is an immense concern, as connective tissue and skin cells come into direct contact with toxins. The…
Viperid snakebite envenomation is characterized by local and systemic effects due to the concerted activity of a variety of toxins displaying synergistic and antagonistic functions. Each stage of the envenomation phenomenon generates important changes at the molecular, cellular, tissue and organismal levels. Among the challenges of studying venoms and envenomation, discovering the molecul…
In Brazil, snakes of the Bothrops genus are responsible for more than 90% of snakebite cases, in which the clinical outcomes after the bite involve local to systemic effects, with the presence of edema, hemorrhage, necrosis, coagulopathy, and renal failure. Hence, to better understand the mechanisms behind venom toxicity, especially in the kidneys, the general objective of the present pro…
(Only some records are available in English at this moment)
Envenomation due to snakebite is a major concern, given the severity of accidents and the high number of deaths occurring each year. In Brazil, Bothrops snakes account for more than 70% of snakebite accidents, and envenomation caused by these snakes often promotes intense pain, edema, hemorrhage, necrosis, disturbances in blood coagulation, cardiovascular disorders, and renal failure. The…
PA-BJ is a Bothrops jararaca venom serine proteinase that triggers platelet-aggregation in a thrombin-like fashion by cleaving the protease-activated receptors PAR-1 and PAR-4 on platelets. We recently carried out a study to comparatively analyze the aggregation of platelets activated by thrombin, one of the most important platelet agonists, and PA-BJ. For this purpose, approaches of mass…
The structural variability is a feature of snake venoms, and glycosylation is a major post-translational modification that contributes to diversification of proteomes. Recent studies by our group on the role of glycosylation in events of venom speciation in the Bothrops genus suggest its conservation, in parallel with other molecular markers that determine phylogenetic classification duri…
(Only some records are available in English at this moment)
Snakebite envenomation is recognized in category A of the Neglected Tropical Diseases by the World Health Organization (WHO) due to the worldwide burden of snakebite death and disability. Although the local effects of bites are well documented, knowledge on the systemic effects of snake venoms is limited. Envenomation by Viperidae snakes causes hypotension, ultimately leading to shock, co…
Protein glycosylation is one of the major post-translational modifications (PTMs) in viperid snake venoms, and contributes to diversification of proteomes. We have shown that Bothrops venoms are markedly defined by their content of glycoproteins, and that most N-glycan structures present in eight Bothrops venoms contain sialic acid units. To further investigate proteome venom variation an…
Snake venoms are a rich source of molecules with biological activity, most of which are proteins. The presence of post-translational modification (PTM) in these proteins, such as glycosylation, has been evidenced in many studies. However, the full characterization of this PTM is still poorly known, regardless of its importance. Mass spectrometry is the primary technique for protein glycos…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 9 / 5 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 23 / 15 | Completed scholarships in Brazil |
| 8 / 7 | Completed scholarships abroad |
| 47 / 34 | All research grants and scholarships |
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