Marcello Delano Bronstein

• Abstract

  Although pituitary tumors are usually benign, about 5-35% have invasive behavior, extending to local tissues, including the cavernous sinus, sphenoid sinus, orbit and clivus. The reasons for these differences are poorly understood and, to date, there is no effective marker capable of predicting the invasive behavior of pituitary tumors. Considering that the invasiveness is the major deter…

  Analysis of plasma and tissue expression of matrix metalloproteinases 2 and 9 in patients with pituitary adenomas and its correlation with invasive tumor behavior, AP.R

• Abstract

  Ketoconazole, antifungal agent, which revealed a potent inhibitor of adrenal steroidogenesis, can be used in the management of Cushing's disease when it is not controlled by surgical procedure and/or radiotherapy. Although it was expected that, with the reduction of serum cortisol levels and urinary occurrance elevation of plasma ACTH, this fact is often not observed. A hypothesis to expl…

  Effect and mechanism of ketoconazole on prolactin, GH, ACTH, LH e FSH release by tumoral rat/mouse anterior pituitary cells in vitro, AP.R

• Abstract

  Acromegaly has variable clinical spectrum ranging from cases with classical symptoms associated with multiple co-morbidities to subclinical or asymptomatic. Generally, the severity of clinical manifestations does not correlate with the degree of GH/IGF-I.The laboratory is characterized by high levels of GH and IGF-I.The dose of GH during the test oral glucose tolerance (OGTT) is considere…

  Polymorphisms in genes of GH receptor (GHR) and IGFBP3 in acromegaly: correlation with clinical / laboratory parameters and response to therapy, AP.R

(Only some records are available in English at this moment)