The scientist holds a degree in Biology from Mackenzie University (1989), MSc (1994) and PhD in Physiology (2001) from the University of São Paulo (2001). She is currently an associate professor at Mackenzie University. Her laboratory is interested in understanding the behavioral, physiological and molecular changes induced by obesity and hypothyroidism with special attention to processes of socialization, learning, and memory. (Source: Lattes Curriculum)
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T4 enters the cells through transporters expressed in the plasma membrane, and will be converted to T3 by deiodinases, the metabolically active form of the hormone. About 12 to 36% of the world population carry a single nucleotide polymorphism (SNP) in the DIO2 gene (rs225014) that expresses type 2 deiodinase (D2), resulting in the Ala92-D2 polymorphism. A recent study published by our gr…
Based on preliminary data and on the amount of evidence produced by our group, this research project will investigate the following hypothesis: melanopsin (OPN4) and/or Transient Receptor Potencial channels (TRPs), expressed by cardiomyocytes, monitor among other putative signals, the variation of the core temperature and/or the local metabolic variation. We suggest that temperature varia…
T4 enters the cells through the transporters expressed in the plasma membrane where will be activated to T3 by type 2 deiodinase (D2). T3 then diffuses to the nucleus to interact with its receptors, the TRs, modulating gene transcription. Approximately 12 to 36% of the population presents polymorphism for D2 (Thr92Ala-D2) that correlates positively with intellectual deficiency, bipolarity…
Major depression (MO) is a neuropshychological disorder that results from interplay of genetic and environmental factors and is often associated with disturbances of the hypothalamic/pituitary/thyroid (HPT) axis. 30-40% of patients with MO are resistant to current antidepressant therapy an adjunct therapy has been searched. Euthyroid patients have been treated with T3 to improve the benef…
T3 is key in the development and maintenance of the central nervous system (CNS) by modulating the expression of proteins related to neuronal plasticity, such as BDNF, NT -3, NGF, known as neurotrophins . In hypothyroid animals there is a significant reduction of these proteins and decreased hippocampal neurogenesis resulting in behavioral changes such as depression a…
(Only some records are available in English at this moment)
A single nucleotide polymorphism in the gene encoding the type 2 (D2) deiodase enzyme, DIO2 (rs225014), results in a single amino acid substitution of threonine (Thr) for alanine (Ala) at position 92 in the D2 protein (Thr92AlaD2) and is present in about 12 to 36% of the population. Studies in young Ala92-D2 female mice showed significant cognitive impairment accompanied by alterations in…
Executive functions (EF) correspond to a group of mental processes, associated with intentional behavior, which enables the performance of various activities and plays an essential role in the formation of the individual. One of the components of EF is attention, which provides the interaction between the mind and the environment and is defined as the focus of consciousness in a direction…
The Ala92-D2 polymorphism is a genetic mutation in the enzyme that catalyzes the conversion of T4 to T3, the type 2 desiodinase, that is present in a significant portion of the world population (12 to 36%). Ala92-D2 exhibits low catalytic activity, and it is associated with stress of the Rough Endoplasmic Reticulum (RER), memory and exploratory behavior impairment. Previous results from o…
Alzheimer's disease (AD) is a progressive neurodegenerative disorder clinically characterized by gradual loss of memory and deterioration of other cognitive functions. Alzheimer's is the most common form of dementia among older adults. Both thyroid dysfunctions and dementia are conditions that become more prevalent with age and several studies have demonstrated a possible association betw…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 8 / 6 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 10 / 10 | Completed scholarships in Brazil |
| 21 / 19 | All research grants and scholarships |
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CV Lattes
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