Abstract
The pro-hormone T4 enters target cells through transporters expressed in the plasma membrane and is converted to its active form, T3, by the action of deiodinases. Approximately 12 to 36% of the world population carries a single nucleotide point mutation (SNP) in the DIO2 gene (rs225014) that expresses type 2 deiodinase (D2), resulting in the Ala92-D2 polymorphism. Studies published by ou…