Abstract
T4 enters the cells through transporters expressed in the plasma membrane, and will be converted to T3 by deiodinases, the metabolically active form of the hormone. About 12 to 36% of the world population carry a single nucleotide polymorphism (SNP) in the DIO2 gene (rs225014) that expresses type 2 deiodinase (D2), resulting in the Ala92-D2 polymorphism. A recent study published by our gr…