Rose Maria Carlos
CV Lattes
ResearcherID
ORCID
Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Exatas e de Tecnologia (CCET) (Institutional affiliation for the last research proposal) Birthplace: Brazil
bachelor's at bacharelado em quimica from Universidade de São Paulo (1987), master's at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1992) and doctorate at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1995). Has experience in Chemistry, focusing on Inorganic Photochemistry, acting on the following subjects: complexos de metais de transição, espectroscopia eletrônica, fotosensibilização, fotoquimica and transferencia de eletrons. (Source: Lattes Curriculum)
- Amyloid protein aggregates and the relationship between Alzheimer's Disease and type 2 Diabetes investigated by Ru(II) luminescent complexes, AP.R
Abstract
The aggregation processes of amyloid protein have implications in a number of diseases, including amyloid beta peptide (Ab) in Alzheimer's disease (AD) and insulin in type 2 diabetes. In addition to being costly chronic diseases included in the list of leading causes of death, several studies have indicated a close relationship between them, such as resistance to insulin, which is the r...
- Analysis of the structure-toxicity relationship of b-amyloid peptides and neuroprotective effect of luminescent Ru (II) complexes, AP.R
Abstract
The toxic oligomers of the b-amyloid (bA) peptide generated in the early stages of aggregation are primarily responsible for the synaptic loss of the CNS, causing cognitive changes in Alzheimer's disease (AD) patients. Due to their instability and structural heterogeneity, information on the structure, mechanism, and physiological effects of bA oligomers are not comprehensively known, h...
- Development of luminescent transition metal complexes to recognize and map in real time the aggregation processes of the B-amyloid peptide and of tau protein and to investigate the antioxidant and acetylcholinesterase enzyme inhibition activity, AP.R
Abstract
This proposal solicits financial funds to acquire a FluoTime 100 spectrometer - Pico Quant, reactants, glassware, solvents, gas, and outsourced services. The grant will support research on the development of ruthenium(II) luminescent complexes to recognize and map in real time the modifications on the structure of the peptide b-amyloid (Ab) and Tau protein. Understanding how these meta...
- New Mn(I)-photosentizer complexes: mimicking the electron donor side of photosystem II in artificial photosynthesis, AP.R
(Only some records are available in English at this moment)
- Synthesis of Ru(II) polypyridyl complexes containing perylene-diimide ligands: spectroscopic and electrochemical properties, BP.IC
Abstract
Photoinduced charge separation (CS) excited states are essential processes that occur in nature through the absorption of visible light by chlorophyll in the photosynthetic system generating molecular oxygen and glucose for plants. Due to the importance and scope of applications of these processes, several research groups have been dedicated to the synthesis of artificial molecules such...
- Investigation of the interaction between the luminescent complex cis-(Ru(phen)2(Apy))2 and liposomes as mimetic membrane models, BP.IC
Abstract
Our laboratory has been working on the development of luminescent complexes as teranostic agents for Alzheimer's disease. Recently, we prepared the luminescent complexes cis-[Ru(phen)2(Apy)]2+ (RuApy) in which phen = 1,10-phenanthroline and Apy = 4aminopyridine, 3,4-aminopyridine. For example, the complex containing the 3,4-Apy ligand is absorbed by neuronal cells reaching the cytoplasm...
- Ru(II)-perylenediimide complexes for activation of singlet oxygen: photodynamic therapy and cellular imaging for treatment of Melanoma Cancer, BP.DR
Abstract
We have recently prepared the [Ru(phen)2(pPDIp)]2+ complex which is capable to mimic key features of the photosynthetic center (cumulative absorption of photons to separate charges by electron transfer) to promote challenging chemical. The interplay between the two chromophores Ru(II)-pPDIp coordination and p-p stacking of the pPDIp arrays in the dyad is markedly influenced by the mediu...
- Luminescent polipyridinic Ru(II) complexes: interest to investigate the Tau protein fibril aggregates, BP.IC
Abstract
In this project we intend to prepare and characterize a series of complexes of ruthenium(II) cis-[Ru(phen-L)2(Apy)2]2+ type, containing in the coordination sphere of 1,10-phenanthroline ligands with the substituent 5-methyl and 4,7-diphenyl and aminopyridines and investigate the effect and influence of substituent on the spectroscopic and electrochemical properties of complexes. The pla...
- Multifunctional transition metal complexes to treatment and diagnosis of Alzheimer's Disease, BP.MS
Abstract
In this project we intend to develop luminescent transition metal complexes of the type cis-[Ru(a-diimina)2(Apy)2]2+, Apy= 4-aminopyridine and 3,4-aminopyridine to diagnosis and treatment of Alzheimer's Disease (AD). AD is a progressive neurodegenerative disease that causes injury in the memory and cognitive function of elderly. The misfolding of amyloid-b (Ab-1-42) into oligomers and f...
- Luminescent metallic complexes with phenolic acids coordinated selective targets to mitochondria and antioxidant activity mapping in real time by fluorescent techniques, BP.DR
Abstract
Mitochondrias are organelles essentials for the life and death of the cell, participating of the cellular energy metabolism as well as in the control of programmed cell death. In this project we chose to develop mitochondria-targeted antioxidants because the respiratory chain is the major source of reactive oxygen species in vivo, and mitochondrial oxidative damage is the cause or lead ...
(Only some records are available in English at this moment)
- Luminescent quenching of riboflavin excited state and protective effects on carotenoids radical by magnesium complexes containing hesperidin and poliphenols, BE.EP.DR
Abstract
Mitochondrias are organelles essentials for the life and death of the cell, participating of the cellular energy metabolism as well as in the control of programmed cell death. In this project we chose to develop mitochondria-targeted antioxidants because the respiratory chain is the major source of reactive oxygen species in vivo, and mitochondrial oxidative damage is the cause or lea...
- Green photochemistry: development of transition metal complexes for activation of luminescent singlet oxygen and its application in the disinfection of wastewaters contaminated with pathogenic microorganisms (Escherichia coli and Enterococcus faecalis), BE.EP.DR
Abstract
In this project we intend to develop luminescent transition metals to act as photocatalysts for disinfection of water contaminated with pathogenic microorganisms. ¬The system was planned to work in rural and/or in small communities of poor sanitation, where lack of infrastructure, funding for operating expenses, plus the lack of training of users limit the use of conventional technologi...
- Probing photoinduced charge transfer process and aggregation in excited State of mono- and bi-nuclear compounds, BE.EP.PD
Abstract
The purpose of this project is develop luminescent Ru-Mn binuclear compounds, stable to thermal and photochemical reactions to mimetize the chemical step of natural photosynthesis. For this we have synthesized the complex [(phen)2Ru(phen)perylene(phen)-Mn(CO)3Br] where phen = 1,10- phenanthroline. The complex prepared shows intense luminescence in the visible region, is stable both ther...
| 1 / 1 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 17 / 10 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 29 / 21 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 12 |
| Citations | 95 |
| Cit./Article | 7.9 |
| Data from Web of Science | |
OLIVEIRA, REGINA M. M.; DE SOUZA DANIEL, JULIANA F.; CARLOS, ROSE M.. Synthesis, spectroscopic characterization and biological activity of cis-[Ru(hesperidin)(1,10 `-phenanthroline)(2)](PF6) complex. Journal of Molecular Structure, v. 1031, p. 269-274, JAN 16 2013. Web of Science Citations: 2. (09/08218-0, 08/57859-5)
OLIVEIRA, REGINA M. M.; DE SOUZA DANIEL, JULIANA F.; DE AGUIAR, INARA; DAS GRACAS FERNANDES DA SILVA, MARIA FATIMA; FERNANDES, JOAO BATISTA; CARLOS, ROSE M.. Structural effects on the hesperidin properties obtained by chelation to magnesium complexes. Journal of Inorganic Biochemistry, v. 129, p. 35-42, DEC 2013. Web of Science Citations: 12. (09/08218-0, 08/57859-5)
CARLOS‚ R.M.; CARLOS‚ I.A.; NETO‚ B.S.L.; NEUMANN‚ M.G.. Spectroscopic and electrochemical properties of [Mn (phen)(CO)3(imidazole)](SO3 CF3) complexes. Inorganica Chimica Acta, v. 299, n. 2, p. 231-237, 2000.
DE CAMPOS, ISABELE AP. S.; DOS SANTOS, EDJANE R.; SELLANI, TARCISO ALMEIDA; HERBOZO, CAROLINA C. A.; RODRIGUES, ELAINE G.; ROVEDA, ANTONIO C.; PAZIN, WALLANCE M.; ITO, AMANDO S.; SANTANA, VINICIUS T.; NASCIMENTO, OTACIRO R.; et al. Influence of the Medium on the Photochemical and Photophysical Properties of [Ru(phen)(2)(pPDIp)](2+). CHEMPHOTOCHEM, v. 2, n. 8, p. 757-764, AUG 2018. Web of Science Citations: 0. (17/00839-1, 16/09633-4)
SOUSA MAIA, PAULO JOSE; DE AGUIAR, INARA; VELLOSO, MARISOL DOS SANTOS; ZHANG, DONG; DOS SANTOS, EDJANE ROCHA; DE OLIVEIRA, JONATAS RAFAEL; JUNQUEIRA, JULIANA CAMPOS; SELKE, MATTHIAS; CARLOS, ROSE MARIA. Singlet oxygen production by a polypyridine ruthenium (II) complex with a perylene monoimide derivative: A strategy for photodynamic inactivation of Candida albicans. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, v. 353, p. 536-545, FEB 15 2018. Web of Science Citations: 4. (14/17476-0, 12/09449-8)
DE AGUIAR, INARA; LIMA, FRANCISCO C. A.; ELLENA, JAVIER; MALTA, VALERIA R. S.; CARLOS, ROSE M.. Study of the phenanthroline-Mn-imidazole bonding in Mn(I) triscarbonyl complex: A X-ray and DFT computational analysis. COMPUTATIONAL AND THEORETICAL CHEMISTRY, v. 965, n. 1, p. 7-14, APR 2011. Web of Science Citations: 3. (09/08218-0)
CARDOSO, CAROLINA R.; DE AGUIAR, INARA; CAMILO, MARIANA R.; LIMA, MARCIA V. S.; ITO, AMANDO S.; BAPTISTA, MAURICIO S.; PAVANI, CHRISTIANE; VENANCIO, TIAGO; CARLOS, ROSE M.. Synthesis, spectroscopic characterization, photochemical and photophysical properties and biological activities of ruthenium complexes with mono- and bi-dentate histamine ligand. DALTON TRANSACTIONS, v. 41, n. 22, p. 6726-6734, 2012. Web of Science Citations: 7. (09/08218-0)
SILVA, DEBORA E. S.; CALI, MARIANA P.; PAZIN, WALLANCE M.; CARLOS-LIMA, ESTEVAO; SALLES TREVISAN, MARIA TERESA; VENANCIO, TIAGO; ARCISIO-MIRANDA, MANOEL; ITO, AMANDO S.; CARLOS, ROSE M.. Luminescent Ru(II) Phenanthroline Complexes as a Probe for Real-Time Imaging of A beta Self-Aggregation and Therapeutic Applications in Alzheimer's Disease. Journal of Medicinal Chemistry, v. 59, n. 19, p. 9215-9227, OCT 13 2016. Web of Science Citations: 7. (14/12538-8, 14/24643-0, 12/02065-0, 14/26895-7, 14/07935-8)
DOS SANTOS, EDJANE R.; PINA, JOAO; VENANCIO, TIAGO; SERPA, CARLOS; MARTINHO, JOSE M. G.; CARLOS, ROSE MARIA. Photoinduced Energy and Electron-Transfer Reactions by Polypyridine Ruthenium(II) Complexes Containing a Derivatized Perylene Diimide. Journal of Physical Chemistry C, v. 120, n. 40, p. 22831-22843, OCT 13 2016. Web of Science Citations: 9. (11/10882-5, 13/23943-8, 14/12538-8)
CARDOSO, CAROLINA R.; LIMA, MARCIA V. S.; CHELESKI, JULIANA; PETERSON, ERICA J.; VENANCIO, TIAGO; FARRELL, NICHOLAS P.; CARLOS, ROSE M.. Luminescent Ruthenium Complexes for Theranostic Applications. Journal of Medicinal Chemistry, v. 57, n. 11, p. 4906-4915, JUN 12 2014. Web of Science Citations: 26. (09/08218-0)
DE AGUIAR, INARA; DOS SANTOS, EDJANE ROCHA; MAFUD, ANA CAROLINA; ANNIES, VINICIUS; NAVARRO-SILVA, MARIO ANTONIO; DOS SANTOS MALTA, VALERIA RODRIGUES; DO PRADO GAMBARDELLA, MARIA TERESA; MARQUES, FRANCISCO DE ASSIS; CARLOS, ROSE MARIA. Synthesis and characterization of Mn(I) complexes and their larvicidal activity against Aedes aegypti, vector of dengue fever. Inorganic Chemistry Communications, v. 84, p. 49-55, OCT 2017. Web of Science Citations: 3. (09/08218-0, 14/02282-6)
CAMILO, MARIANA R.; CARDOSO, CAROLINA R.; CARLOS, ROSE M.; LEVER, A. B. P.. Photosolvolysis of cis-[Ru(alpha-diimine)(2)(4-aminopyridine)(2)](2+) Complexes: Photophysical, Spectroscopic, and Density Functional Theory Analysis. Inorganic Chemistry, v. 53, n. 7, p. 3694-3708, APR 7 2014. Web of Science Citations: 22. (06/50322-0, 09/08218-0)
MARCHI, RAFAEL C.; SILVA, ELDEVAN S.; SANTOS, JOSENILTON J.; GUILOSKI, IZONETE C.; DE JESUS, HUGO CESAR R.; DE AGUIAR, INARA; KOCK, FLAVIO V. C.; VENANCIO, TIAGO; DA SILVA, MARIA FATIMA G. F.; FERNANDES, JOAO BATISTA; et al. Synthesis, Characterization, and Low-Toxicity Study of a Magnesium(II) Complex Containing an Isovanillate Group. ACS OMEGA, v. 5, n. 7, p. 3504-3512, FEB 25 2020. Web of Science Citations: 0. (18/09145-5, 13/05536-6, 17/00839-1, 15/23146-6, 18/16040-5, 17/15455-4)
Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação BR1020180687085 - Universidade Estadual Paulista (UNESP); Universidade Federal de São Carlos (UFSCAR); Universidade Federal do Paraná (UFPR). Solicitação em análise e dentro do prazo legal de sigilo previsto na legislação - September 2018, 14