CV Lattes
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Universidade Federal de São Carlos (UFSCAR). Centro de Ciências Exatas e de Tecnologia (CCET) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at bacharelado em quimica from Universidade de São Paulo (1987), master's at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1992) and doctorate at Chemistry from Universidade Estadual Paulista Júlio de Mesquita Filho (1995). Has experience in Chemistry, focusing on Inorganic Photochemistry, acting on the following subjects: complexos de metais de transição, espectroscopia eletrônica, fotosensibilização, fotoquimica and transferencia de eletrons. (Source: Lattes Curriculum)
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Patients with Alzheimer's disease (AD) present high risk of developing type II diabetes mellitus (TD2), and this has an impact on various sectors of our society. The heterogeneous aggregation between the proteins related to these diseases, ²A and hIAPP, has been proposed as a potential molecular mechanism. However, the structural characteristics of the aggregates generated from these inte…
The aggregation processes of amyloid protein have implications in a number of diseases, including amyloid beta peptide (Ab) in Alzheimer's disease (AD) and insulin in type 2 diabetes. In addition to being costly chronic diseases included in the list of leading causes of death, several studies have indicated a close relationship between them, such as resistance to insulin, which is the rea…
The toxic oligomers of the b-amyloid (bA) peptide generated in the early stages of aggregation are primarily responsible for the synaptic loss of the CNS, causing cognitive changes in Alzheimer's disease (AD) patients. Due to their instability and structural heterogeneity, information on the structure, mechanism, and physiological effects of bA oligomers are not comprehensively known, hen…
(Only some records are available in English at this moment)
Alzheimer's disease (AD), the most common among dementias, is a devastating neurodegenerative disease and one of the biggest concerns for public health networks in the world. The pathological characteristic of AD are the senile plaques formed mainly by the aggregation of amyloid beta peptide (bA). Despite the importance of bA1-42 aggregates in the molecular etiology of AD, the amino acid …
For centuries light has been used to treat various medical conditions such as in thetreatment of psoriasis and vitiligo. Light is also used to induce a chemical transformationin the biological medium by activating compounds that are not thermally active. Thesephotoinduced reactions have the potential to revolutionize the field of photomedicine andintelligent drug delivery systems. In this…
Alzheimer's disease (AD) is characterized by the progressive loss of neurological functions such as loss of recent memory and degeneration of neuronal tissues and the formation of senile plaques mainly by the accumulation of amyloid beta peptide (A²) in the brain. A² aggregates are formed both by aggregation and homogeneous fibrillation of A², as well as by heterogeneous interactions betw…
In this project, the aim is to prepare Ru(II) polypyridine complexes and assess the feasibility of applying these complexes as luminescent molecular probes for studies related to cell membranes. To achieve this, the complexes [Ru(phen)2NDI]2+ and [Ru(bpy)2NDI]2+ (RuNDI) will be synthesized and characterized, where phen = 1,10-phenanthroline, bpy = 2,2-bipyridine, NDI = naphthalenediimide …
The aggregation processes of amyloid proteins in vivo are associated with the pathogenesis of several incurable neurologic diseases and in vitro they preclude or shows limitations both in storage and therapeutic applications such as on the biopharmaceutical protein insulin. However, stabilizing this conformation has disadvantages, since insulin is active in the monomeric form and dissocia…
Diabetes is a chronic progressive disease characterized by high blood glucose levels and associated with tissue and organ damage, therefore, access to affordable treatment, including insulin, is critical to the survival of people with diabetes. Insulin was the first biopharmaceutical produced on an industrial scale for the treatment of insulin-dependent diabetes. Insulin is an amyloid pro…
(Only some records are available in English at this moment)
Alzheimer's disease (AD), the most common form of dementia, is a devastatingneurodegenerative disease and a major concern for global public health systems. Itspathological hallmark is senile plaques, primarily formed by the aggregation of the betaamyloid (A¿) peptide. While the importance of A¿1-42 aggregates in AD's molecularetiology is well recognized, the amino acid sequence responsibl…
The aggregation processes of amyloid beta peptide (A²) and accumulation in the brain is a neuropathological hallmark of Alzheimer diseases (AD). Among the various species of A², the oligomeric species (OA²) is considered to be the most toxic to AD. These species are generated in the early stages of aggregation by combining dimers, trimers, and even dodecamers of A². Thus, the composition,…
The neurotoxicity of oligomeric species of amyloid beta (OA²) peptide has been linked to damage caused to cell membranes by pore formation through interactions with cholesterol and ganglioside lipids. Consequently, studies of compounds that act directly on OA² at lipid membrane interfaces has enlarged considerably. Recently, we have demonstrated that the luminescent cis-[Ru(phen)2(3,4-Apy…
The design of organic-inorganic hybrid systems with near-infrared absorption and emission properties is attracting a great interest due to the variety of applications, including catalysis, medicine and luminescent sensing. An issue in planning organic-inorganic hybrid systems is the design of bridges to connect the different moieties and potentiate synergistic action. Following this strat…
(Only some records are available in English at this moment)
| 7 / 6 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 27 / 20 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 44 / 36 | All research grants and scholarships |
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