Lilian Cristina Pereira

• XXII Brasilian Congress of Toxicology - CBTox, AR.BR

• Abstract

  The massive use of agricultural inputs, pharmaceuticals and industrial chemicals, among other chemical substances, causes environmental contamination with bioaccumulation and biomagnification of their residues, which may lead to inadequate exposures and increase the incidence of human diseases. On the other hand, experimental studies have the capacity to predict the toxicity of these emer…

  Cellular and molecular mechanisms of hepatotoxicity and embryotoxicity by emerging contaminants decametilcyclopentasiloxane and triclopyr, AP.R

• Abstract

  Humans are exposed to a multitude of day-to-day chemicals: pesticides, pharmaceuticals and industrial chemicals, among other substances. To ensure adequate protection of human health and the environment, it is essential that the potential of these compounds to induce toxicity is adequately verified. Experimental studies have the capacity to predict the toxicity of these emerging contamina…

  Comparison of HepG2 cells culture in monolayer (2D) and three-dimensional (3D) at hepatotoxicity evaluation induced by decamethylcyclopentasiloxane (D5) and triclopyr, BP.DD

• Abstract

  Currently, the development and optimization of alternative methods follows a strong international trend as an alternative to the use of animals in research. Among the new technologies being developed, there are different types of three-dimensional culture (3D) of cells that reproduce more reliably the in vivo environment then monolayers culture. Within this context, our research group, wh…

  Evaluation of autophagy/mitophagy induced by brominated flame retardants using cell liver in 3D compared to the conventional monolayer model, BP.PD

• Abstract

  The flame retardants are brominated materials used in large scale in various consumer goods of modern life to increase its fire resistance and / or higher temperatures, eg in case of fire by reducing the spread of fire and interfering with combustion material, thus increasing the chances of escape and reducing the severity of burns. For this purpose, polybrominated diphenyl ethers (PBDEs)…

  Evaluation of the effects of polybrominated diphenyl ethers congeners, BDE-100 and BDE-153, on the HepG2 cell line and human lymphocytes: cytotoxic, genotoxic and mutagenic effects., BP.DR

(Only some records are available in English at this moment)