Ana Campa

• Abstract

  During the last years, part of the activities of my research group has been concentrated in Tryptophan (Trp) metabolism in tumor and immune cells. Among our recent contribution are the optimization and validation of a bioanalytical method for simultaneous detection of 16 metabolites of Trp in biological matrices, the description of IFN-³ effect (an inducer of the main Trp metabolic pathwa…

  Tryptophan metabolism in focus: in the skin homeostasis, in melanomas malignancy, in relation to hypoxia and in the characterization of immune cells phenotype., AP.R

• Abstract

  For some types of tumors it was evidenciated a positive correlation between serum amyloid A (SAA) production and malignance. Our group has described the role of SAA as a growth factor stimulating proliferation of different cell types. In two glioma lines, beyond the effect in proliferation, SAA modified migration and invasion and it was dependent of matrix metalloproteinases. Interestingl…

  Serum amyloid A and melanomas: receptors, matrix metalloproteinases and immune system interactions, AP.R

• Abstract

  The inflammation resulting from obesity is well characterized. More recently it has been discussed, if obesity could be a consequence of the inflammatory process. It is known that lipopolysaccharide (LPS), administered in very low doses by continuous infusion (mimicking the condition of endotoxemia caused by intestinal microbiota), induces insulin resistance, obesity and diabetes in mice.…

  Acute inflammation in the genesis of obesity: experimental model focused on the protein serum amyloid a (SAA) as an adipose tissue marker of inflammation and hypertrophy, AP.R

(Only some records are available in English at this moment)

• Abstract

  The aryl hydrocarbon receptor (AHR) has been subject of research for its importance in physiological processes and diseases, such as immunological tolerance and tumor immuno-escape. Exogenous and endogenous compounds are ligands of AHR. Kynurenine (Kyn), one of the metabolites resulting from the degradation of tryptophan (Trp), stands out among the endogenous ligands of AHR. In relation t…

  Gene edition of the aryl hydrocarbon receptor by the CRISPR-Cas9 vector system RNA guide in melanoma, BP.IC

• Abstract

  Several benefits of exposure sunlight have been described, as the direct relation with psychological well-being. Moreover, the light is related to the maintenance of homeostasis and skin metabolismo. In the skin, tryptophan (TRP) is metabolized to biologically active compounds and it is believed that serotonin synthesis, metabolite of TRP, in phototherapy is part of the remission mechanis…

  Sunlight effects on tryptophan metabolism in skin cells, BP.MS

• Abstract

  Hypoxia is a commonly present factor in tumors and it is responsible for important changes in tumor cell metabolism, with an essential task in metastatis and therapy resistance. In turn, the catabolism of the amino acid tryptophan has been increasing as a target in cancer research and it is an important mechanism in tumor immune escape. Besides there are lots of studies that evaluate hypo…

  Effects of hypoxia on the tryptophan metabolic pathways in gliomas, BP.IC

(Only some records are available in English at this moment)

• Abstract

  Faithful to its inherent aggressive, melanomas are remarkably resistant to all forms of cancer therapies. The combination of chemotherapy with biomolecules such as IL-2 and IFN-alpha does not appear to be an effective management. However, clinical trials are underway to evaluate new therapeutic strategies. In this context, melatonin (MLT) has been shown to be an excellent adjunct to conve…

  Signaling pathways of melanoma regression: focus on melatonin, BE.EP.PD