Professor of the Department of Basic and Oral Biology at School of Dentistry of Ribeirão Preto, University of São Paulo (FORP-USP). Graduated in Dentistry from the FORP-USP (1999), MSc and PhD in Biological Sciences (Pharmacology) from the School of Medicine of Ribeirão Preto, University of São Paulo (2003 and 2004). Postdoctoral internship with the Department of Cell Biology of the University of Massachusetts Medical School (2008-2010). Member of the editorial board of the Journal of Dental Research. Experience in Dentistry, with an emphasis on cell biology, working on the following topics: cell signaling in bone tissue and regenerative medicine (tissue engineering and cell therapy) of bone tissue. (Source: Lattes Curriculum)
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Cell therapy using stem cells derived from several tissues has been the focus of scientific investigations as a promising alternative for treating bone defects. Embryonic stem cells exhibit high plasticity and self-renewal potential, increasing their capacity of differentiating into cells of all tissues, excepting the embryonic ones. To minimize immunological aspects, and ethical and reli…
Osteocytes are the most abundant cells in bone tissue with key role for the skeleton function. They are derived from the osteoprogenitor lineage, exhibit a dendritic morphology and are embedded by the mineralized matrix during the bone formation process. Osteocytes regulate the activity of osteoblasts and osteoclasts through the secretion of factors that modulate several signaling pathway…
The osseointegration of titanium (Ti) implants is based on bone remodeling, which involves a balance between bone tissue formation by osteoblasts and tissue resorption by osteoclasts. Our group has shown that a Ti surface with nanotopography obtained by chemical conditioning with H2SO4/H2O2 solution is capable of inducing osteoblast differentiation under both osteogenic and non-osteogenic…
Bone tissue has high capacity of regeneration, but in several situations the extent of the injury overcomes its regenerative potential. In this scenario, therapies based on the use of mesenchymal stem cells (MSCs) have aroused the attention of many researchers for being a promising alternative compared with the available treatments. However, many molecular, cellular and tissue characteris…
(Only some records are available in English at this moment)
The process of bone regeneration/repair is regulated by numerous molecules and signaling pathways, including the engrailed-1 protein (EN1), a transcription factor that participates in the regulation of craniofacial development, which is still poorly studied in the context of bone tissue, especially in bone repair. Adipose tissue derived mesenchymal stem cells (AT-MSCs) are of therapeutic …
Osteoblasts are key cells for bone formation and repair and the process of osteoblast differentiation is regulated by the runt-related transcription factor 2 (Runx2), as well as several other proteins that act on cell signaling pathways. Results of our research group showed that the extracellular matrix protein agrin is expressed by mesenchymal stem cells (MSCs) and osteoblasts and that t…
Cell therapy using mesenchymal stem cells derived from several tissues has been the focus of scientific investigations as a promising alternative for treating bone defects. MSCs derived from adipose tissue (MSCs-AT), when aspirated and isolated, present themselves as a safe source of cells for regenerative medicine and cell therapy, since through their plasticity and angiogenic role, they…
(Only some records are available in English at this moment)
The osteocyte-osteoblast interactions affect bone repair and remodeling, which are relevant to theosseointegration of titanium (Ti) implants. We have demonstrated that Ti with nanotopography (Ti-Nano) generated by treatment with H2SO4 and H2O2 favors osteoblast differentiation by modulating several cell signaling pathways and attenuates the inhibitory effect of osteoclasts on osteoblast d…
The bone morphogenetic protein 9 (BMP-9) exhibits high osseoinductive capacity. We have demonstrated that Ti with nanotopography (Ti-Nano) generated by treatment with H2SO4 and H2O2 favors osteoblast differentiation by modulating several cell signaling pathways and that mesenchymal stem cells grown on this nanotopography are more responsive to BMP-9. In this context, the aim of this study…
Bone tissue has high capacity of regeneration, but in several situations the extent of the injury overcomes its regenerative potential. In this scenario, therapies based on the use of mesenchymal stem cells (MSCs) have aroused the attention of many researchers for being a promising alternative compared with the available treatments. However, many molecular, cellular and tissue characteris…
(Only some records are available in English at this moment)
Agrin is an extracellular matrix protein with well-described functions in neuromuscular junctions, synaptic gaps of the central nervous system, and immunological synapses. Agrin can promote cardiac regeneration after myocardial infarction, maintenance of cartilage, and osteoblastic differentiation. Preliminary results demonstrated that the overexpression of agrin modulated the gene expres…
Pyle's disease is a rare skeletal disorder of long bone with wide metaphysis, increased trabecular bone, cortical thinning, and increased fragility fracture risk caused by a genetic deficiency in Secreted Frizzled Receptor Protein 4 (Sfrp4). In Sfrp4 null mice, cortical thinning is due to a deregulation of periosteal bone formation and endosteal remodeling mainly because activation of non…
Cell therapy using stem cells derived from different tissues of the body has been the subject of scientific investigations in the field of regenerative medicine as it is a promising alternative for the treatment of bone diseases. Among the types of stem cells, it is known that embryonic stem cells have a high plasticity and a great potential for self-renewal, which increases their ability…
The osseointegration of titanium (Ti) implants is based on bone remodeling, which involves a balance between bone tissue formation by osteoblasts and tissue resorption by osteoclasts. Our group has shown that a Ti surface with nanotopography obtained by chemical conditioning with H2SO4/H2O2 solution is capable of inducing osteoblast differentiation under both osteogenic and non-osteogenic…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing grants |
| 15 / 13 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 42 / 38 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 69 / 63 | All research grants and scholarships |
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CV Lattes
ORCID