Tiago Rodrigues
CV Lattes
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Ministério da Educação (Brasil). Universidade Federal do ABC (UFABC). Centro de Ciências Naturais e Humanas (CCNH) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Faculdade de Ciências Farmacêuticas de Ribeirão Pr from Universidade de São Paulo (1997), master's at Biochemistry from Universidade de São Paulo (1999) and ph.d. at Biochemistry from Faculdade de Medicina de Ribeirão Preto (2003). Has experience in Biochemistry, focusing on Metabolism and Bioenergetics, acting on the following subjects: mitochondria, phenothiazines, mitochondrial permeability transition, lipid peroxidation and apoptosis. (Source: Lattes Curriculum)
- Alterations of mitochondrial morphology and dynamics in cancer: understanding of tumor biology and prospecting new therapeutic targets, AP.R
Abstract
Melanoma is a tumor originated in melanocytes predisposed to the accumulation of DNA damage, resulting in genetic mutations that favor its malignancy, such as the stimulation of blood vessel growth, immune response evasion, tumor invasion and metastasis. Although potentially curable sometimes, malignant melanoma is an aggressive type of cancer, with a high mortality resistance developme...
- Investigation of Phenothiazine-Induced cell death mechanisms in tumor cells: changes in gene expression, role of Bcl-2 family proteins, and er stress, AP.R
Abstract
Literature data have shown that psycotropic drugs derived from phenothiazines present antitumor activity. Working with isolated rat liver mitochondria, we previously showed that phenothiazine derivatives induced the mitochondrial permeability transition associated with cytochrome c release. After, we established the cytotoxic potential of different phenothiazine derivatives and determin...
- Protective effect of Plantago major extract against t-BOOH-induced mitochondrial oxidative damage and cytotoxicity, PUB.ART
Abstract
Plantago major L. produces several chemical substances with anti-inflammatory and analgesic activities and its use in the treatment of oral and throat inflammation in popular medicine is well described. In this study, the antioxidant potential of the Plantago major hydroethanolic extract was screened and its protective action was evaluated against t-BOOH-induced oxidative stress. The ex...
- New applications of phenothiazines and Palladacycles: nanostructured systems to the mechanistic study of death in tumor cells, AP.R
Abstract
According to the estimative of national and international organizations, cancer incidence has grown alarmingly in world population due to the elevation of life expectancy and some habits adopted by population that constitutes risk factors for the development of this disease. Therefore, beyond earlier diagnosis and prevention, it is noteworthy the development of safe and efficacy therapi...
(Only some records are available in English at this moment)
- Study of the mechanisms of Thioridazine-Induced cell death in tumor cells: focus on signaling pathways and expression of Bcl-2 family proteins, BP.DR
Abstract
Cancer is a worldwide occurrence disease, which is considered a public health problem since it is the leading cause of population death. In 2007, it was registered 7.9 millions of deaths caused by this disease and the expectations for the next years are an increase in this number. Data indicates that will occur at least 12 millions of deaths until the year of 2030. The costs with cancer...
- Investigation of the effects of triciclic psychodrugs against the oxidative stress in Neuro-2a cells, BP.MS
Abstract
The pathogenesis of neuronal disorders has been associated to the cell death with involvement of oxidative stress. The increase in the mitochondrial free radical production, persistent changes in the mitochondrial integrity (mitochondrial permeability transition, MPT) and mitochondrial depolarization seem to play central role. In this project it will be studied the effects of three psyc...
- Nanostructured systems containing phenothiazines: effects on bioenergetics and mechanisms of death in tumor cells, BP.DR
Abstract
Multi-drug resistance (MDR) is the main problem that contributes to the antitumoral chemotherapy fail. Such resistance is related to overexpression or inactivation of genes associated to signaling in tumor cells. The most studied mechanism of MDR involves the glycoprotein P (Pgp), the product of MDR1 gene. The MDR reversion by inhibition of Pgp has been described for several chemicals, ...
(Only some records are available in English at this moment)
- Thioridazine-induced apoptosis: studies on mitochondrial outer membrane permeabilization and interaction with Bcl-2 proteins, BE.EP.DR
Abstract
Literature data have shown that psycotropic drugs derived from phenothiazines present antitumor activity. Data from our group have evidenced relevant biological effects of phenothiazines and its analogues in mitochondria, and these effects may be related to the drug capability of inducing cell death. Among the studied phenothiazine derivatives in all models studied, thioridazine was the...
| 1 / 1 | Ongoing research grants |
| 8 / 7 | Completed research grants |
| 13 / 7 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 23 / 16 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 13 |
| Citations | 149 |
| Cit./Article | 11.5 |
| Data from Web of Science | |
GUIMARAES, NATALIA S. S.; MELLO, JOYCE C.; PAIVA, JULIANA S.; BUENO, PAULA C. P.; BERRETTA, ANDRESA A.; TORQUATO, RICARDO J.; NANTES, ISELI L.; RODRIGUES, TIAGO. Baccharis dracunculifolia, the main source of green propolis, exhibits potent antioxidant activity and prevents oxidative mitochondrial damage. Food and Chemical Toxicology, v. 50, n. 3-4, p. 1091-1097, MAR-APR 2012. Web of Science Citations: 40. (08/01724-4, 08/07246-7)
MORAES, V. W. R.; CAIRES, A. C. F.; PAREDES-GAMERO, E. J.; RODRIGUES, T.. Organopalladium compound 7b targets mitochondrial thiols and induces caspase-dependent apoptosis in human myeloid leukemia cells. CELL DEATH & DISEASE, v. 4, JUN 2013. Web of Science Citations: 19. (12/12247-8)
FERRAZ, LETICIA S.; WATASHI, CAROLINA M.; COLTURATO-KIDO, CARINA; PELEGRINO, MILENA T.; PAREDES-GAMERO, EDGAR J.; WELLER, RICHARD B.; SEABRA, AMEDEA B.; RODRIGUES, TIAGO. Antitumor Potential of S-Nitrosothiol-Containing Polymeric Nanoparticles against Melanoma. MOLECULAR PHARMACEUTICS, v. 15, n. 3, SI, p. 1160-1168, MAR 2018. Web of Science Citations: 4. (16/07367-5, 12/12247-8)
DE FIGUEIREDO, LAYSA P.; IBIAPINO, AMANDA L.; DO AMARAL, DANIEL N.; FERRAZ, LETICIA S.; RODRIGUES, TIAGO; BARREIRO, ELIEZER J.; LIMA, LIDIA M.; FERREIRA, FABIO F.. Structural characterization and cytotoxicity studies of different forms of a combretastatin A4 analogue. Journal of Molecular Structure, v. 1147, p. 226-234, NOV 5 2017. Web of Science Citations: 3. (12/12247-8)
SANTANA, DEBORA P.; FARIA, PRISCILA A.; PAREDES-GAMERO, EDGAR J.; CAIRES, ANTONIO C. F.; NANTES, ISELI L.; RODRIGUES, TIAGO. Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis. Biochemical Journal, v. 417, n. 1, p. 247-256, JAN 1 2009. Web of Science Citations: 23. (06/00995-9)
DE MELLO, JOYCE C.; MORAES, VIVIAN W. R.; WATASHI, CAROLINA M.; DA SILVA, DEYSE C.; CAVALCANTI, LEIDE P.; FRANCO, MARGARETH K. K. D.; YOKAICHIYA, FABIANO; DE ARAUJO, DANIELE R.; RODRIGUES, TIAGO. Enhancement of chlorpromazine antitumor activity by Pluronics F127/L81 nanostructured system against human multidrug resistant leukemia. PHARMACOLOGICAL RESEARCH, v. 111, p. 102-112, SEP 2016. Web of Science Citations: 5. (13/05099-5, 11/21433-7, 12/12247-8)
JABES, DANIELA LEITE; DE FREITAS OLIVEIRA, ANA CLAUDIA; ALENCAR, VALQUIRIA CAMPOS; MENEGIDIO, FABIANO BEZERRA; SOUZA RENO, DEBORA LILIANE; SANTOS, DAIENE SOUZA; BARBOSA, DAVID ACIOLE; VILAS BOAS, RENATA OZELAMI; DE OLIVEIRA RODRIGUES CUNHA, RODRIGO LUIZ; RODRIGUES, TIAGO; et al. Thioridazine inhibits gene expression control of the cell wall signaling pathway (CWI) in the human pathogenic fungus Paracoccidioides brasiliensis. Molecular Genetics and Genomics, v. 291, n. 3, p. 1347-1362, JUN 2016. Web of Science Citations: 3. (12/12247-8)
RODRIGUES, TIAGO; NUNEZ ESTEVEZ, GABRIELA NOHEMI; DOS SANTOS TERSARIOL, IVARNE LUIS. Na+/Ca2+ exchangers: Unexploited opportunities for cancer therapy?. Biochemical Pharmacology, v. 163, p. 357-361, MAY 2019. Web of Science Citations: 1. (16/07367-5, 15/03964-6)
PHILOT, ERIC ALLISON; LOPES, DAVID DA MATA; DE SOUZA, ARYANE TOFANELLO; KIMUS BRAZ, ANTONIO SERGIO; NANTES, ISELI LOURENCO; RODRIGUES, TIAGO; PERAHIA, DAVID; MITEVA, MARIA A.; BARBOUR SCOTT, LUIS PAULO. Binding of phenothiazines into allosteric hydrophobic pocket of human thioredoxin 1. EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, v. 45, n. 3, p. 279-286, APR 2016. Web of Science Citations: 0. (12/07456-7, 11/11857-4, 12/12247-8)
DE FARIA, PRISCILA A.; BETTANIN, FERNANDA; CUNHA, RODRIGO L. O. R.; PAREDES-GAMERO, EDGAR J.; HOMEM-DE-MELLO, PAULA; NANTES, ISELI L.; RODRIGUES, TIAGO. Cytotoxicity of phenothiazine derivatives associated with mitochondrial dysfunction: A structure-activity investigation. Toxicology, v. 330, p. 44-54, APR 1 2015. Web of Science Citations: 16. (10/19790-3, 12/12247-8)
JABES, DANIELA LEITE; DE FREITAS OLIVEIRA, ANA CLAUDIA; ALENCAR, VALQUIRIA CAMPOS; MENEGIDIO, FABIANO BEZERRA; SOUZA RENO, DEBORA LILIANE; SANTOS, DAIENE SOUZA; BARBOSA, DAVID ACIOLE; VILAS BOAS, RENATA OZELAMI; DE OLIVEIRA RODRIGUES CUNHA, RODRIGO LUIZ; RODRIGUES, TIAGO; et al. Thioridazine inhibits gene expression control of the cell wall signaling pathway (CWI) in the human pathogenic fungus Paracoccidioides brasiliensis. Molecular Genetics and Genomics, v. 291, n. 3, p. 1347-1362, JUN 2016. Web of Science Citations: 3. (12/12247-8)
MELLO, JOYCE C.; GUIMARAES, NATALIA S. S.; GONZALEZ, MARIANO V. D.; PAIVA, JULIANA S.; PRIETO, TATIANA; NASCIMENTO, OTACIRO R.; RODRIGUES, TIAGO. Hydroxyl scavenging activity accounts for differential antioxidant protection of Plantago major against oxidative toxicity in isolated rat liver mitochondria. Journal of Pharmacy and Pharmacology, v. 64, n. 8, p. 1177-1187, AUG 2012. Web of Science Citations: 6. (08/01724-4)
MELLO, JOYCE C.; GONZALEZ, MARIANO V. D.; MORAES, VIVIAN W. R.; PRIETO, TATIANA; NASCIMENTO, OTACIRO R.; RODRIGUES, TIAGO. Protective Effect of Plantago major Extract against t-BOOH-Induced Mitochondrial Oxidative Damage and Cytotoxicity. Molecules, v. 20, n. 10, p. 17747-17759, OCT 2015. Web of Science Citations: 4. (08/01724-4)
SISTEMAS BINÁRIOS POLOXÂMEROS/DERIVADOS FENOTIAZÍNICOS COMO FORMULAÇÕES FARMACÊUTICAS DE USO LOCAL E/OU SISTÊMICO PARA O TRATAMENTO E A PREVENÇÃO DE CÂNCERES BR1020150289448 - Universidade Federal do ABC (UFABC). Tiago Rodrigues; Daniele Ribeiro De Araujo; Joyce Cristine De Mello - November 2015, 18