graduation at Ciências Biológicas from Universidade de São Paulo (1969), master's at Physiology from Universidade de São Paulo (1973) and doctorate at Physiology from Universidade de São Paulo (1974). Has experience in Physiology, focusing on Comparative Physiology, acting on the following subjects: teleosteo, cromatoforos, melanotropinas, vias de sinalizacao and melanoforo. (Source: Lattes Curriculum)
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The ImageXpress Nano system generates wide-field and high-performance images and is capable of acquiring images from Whole organisms and cellular and intracellular events. With several applications in research on infectious diseases, cell physiology, cancer, cell counting, cell migration assays, finding and development of new drugs, and toxicology, among others, involving 3D cells, cardio…
Based on preliminary data and on the amount of evidence produced by our group, this research project will investigate the following hypothesis: melanopsin (OPN4) and/or transient receptor potencial channels (TRPs), expressed by cardiomyocytes, monitor among other putative signals, the variation of the core temperature and/or the local matbolic variation.We suggest that temperature variat…
Based on preliminary data and on the amount of evidence produced by our group, this research project will investigate the following hypothesis: melanopsin (OPN4) and/or Transient Receptor Potencial channels (TRPs), expressed by cardiomyocytes, monitor among other putative signals, the variation of the core temperature and/or the local metabolic variation. We suggest that temperature varia…
The mammalian photosensitive system committed to non-image forming processes has been well characterized in the eyes. The components of this system are the opsins, biological sensors of light. Opsins are also present in the skin cells, but the biological processes they regulate are largely unknown. Recent evidence resulting from our work and others indicate the role of these sensors in th…
Our research group has been investigating the physiology of photopigments and clock genes in cell models of various vertebrate classes since 2001. During this period the group has published several findings on the mechanism of action of light and hormones on the expression of the photopigment melanopsin and of clock genes in each of our models. The present project arises as the continuati…
(Only some records are available in English at this moment)
The marine ecosystem is subjected to a wide variety of environmental cycles, such as photoperiod and temperature. These cycles provide cues to marine species, leading to the adjustment of biological clocks that control their physiology, ranging from circadian to circalunar and seasonal rhythms. The eyestalk in crustaceans is considered the center of endocrine control, containing a range o…
Cancer cachexia is present in around 80% of advanced cases, being responsible for more than 20% of cancer deaths. A complex metabolic syndrome, cachexia is characterized by the continuous loss of skeletal muscle mass and depletion of fat stores and it is often associated with anorexia and systemic inflammation, among other disorders. Despite great interest, therapy options are limited due…
Obesity is generally defined as the abnormal or excessive accumulation of fat (adipose tissue), resulting in several health risks. Overweight as well as obesity can trigger chronic diseases of the cardiovascular system including heart disease and cerebrovascular accidents (one of the main causes of death in the world). Obesity, being a multifactorial disease, also leads to metabolic disor…
(Only some records are available in English at this moment)
Obesity is generally defined as the abnormal or excessive accumulation of fat (adipose tissue), resulting in several health risks. Overweight and obesity can trigger metabolic disorders such as diabetes and its associated conditions as well as heart disease and cerebrovascular accidents (one of the main causes of death worldwide). Transient potential channels (TRP) appear to be one of the…
The genetic processes that give rise to phenotypic plasticity in complex organisms are primarily orchestrated by alternative splicing (AS), a mechanism by which genetic variants (e.g., single-nucleotide polymorphisms - SNPs located within non-coding genomic regions), in cis, directly influence the alternatively spliced transcripts produced from a gene. Nearly every human gene is alternati…
The present project supported by FAPESP has among its goals, to determine melanopsin function and signaling pathway in non-mammalian vertebrates, mainly in avian, amphibian and teleost cells. Despite the progress already achieved and reported to the agency in Brazil, the possibility to collaborate with one of the most prominent groups in the field has came forth us. Now we have the possib…
| 3 / 3 | Ongoing grants |
| 18 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 44 / 20 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 2 | Completed scholarships abroad |
| 71 / 34 | All research grants and scholarships |
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CV Lattes
ORCID