graduation at Ciências Biológicas from Universidade de São Paulo (1969), master's at Physiology from Universidade de São Paulo (1973) and doctorate at Physiology from Universidade de São Paulo (1974). Has experience in Physiology, focusing on Comparative Physiology, acting on the following subjects: teleosteo, cromatoforos, melanotropinas, vias de sinalizacao and melanoforo. (Source: Lattes Curriculum)
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Based on preliminary data and on the amount of evidence produced by our group, this research project will investigate the following hypothesis: melanopsin (OPN4) and/or Transient Receptor Potencial channels (TRPs), expressed by cardiomyocytes, monitor among other putative signals, the variation of the core temperature and/or the local metabolic variation. We suggest that temperature varia…
The mammalian photosensitive system committed to non-image forming processes has been well characterized in the eyes. The components of this system are the opsins, biological sensors of light. Opsins are also present in the skin cells, but the biological processes they regulate are largely unknown. Recent evidence resulting from our work and others indicate the role of these sensors in th…
Our research group has been investigating the physiology of photopigments and clock genes in cell models of various vertebrate classes since 2001. During this period the group has published several findings on the mechanism of action of light and hormones on the expression of the photopigment melanopsin and of clock genes in each of our models. The present project arises as the continuati…
(Only some records are available in English at this moment)
The opsins, proteins with seven transmembrane domains, are receptors specialized in perceiving the light from prokaryotes to man. Undoing the view that opsins are exclusively light sensors, today it is accepted that opsins form a family of multi-functional molecules that have the potential to perceive temperature and light. In mammals, melanopsin is a retinal photopigment found in a subse…
This proposal has as main approach the proteomics by LC-ESI-MS/MS, to comparatively evaluate heart, brown adipose, and white adipose tissues among WT and KO animals and, therefore, to better understand the role of Opn4, TrpV1, TrpM8, TrpA1, and AdrB1 genes and their associations in the physiology of circadian rhythm under conditions of metabolic stress (Obesity and Cancer Cachexia) and lo…
(Only some records are available in English at this moment)
The genetic processes that give rise to phenotypic plasticity in complex organisms are primarily orchestrated by alternative splicing (AS), a mechanism by which genetic variants (e.g., single-nucleotide polymorphisms - SNPs located within non-coding genomic regions), in cis, directly influence the alternatively spliced transcripts produced from a gene. Nearly every human gene is alternati…
The present project supported by FAPESP has among its goals, to determine melanopsin function and signaling pathway in non-mammalian vertebrates, mainly in avian, amphibian and teleost cells. Despite the progress already achieved and reported to the agency in Brazil, the possibility to collaborate with one of the most prominent groups in the field has came forth us. Now we have the possib…
| 1 / 1 | Ongoing research grants |
| 18 / 6 | Completed research grants |
| 41 / 17 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 2 / 1 | Completed scholarships abroad |
| 63 / 26 | All research grants and scholarships |
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CV Lattes
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