graduation at Medicina from Universidade Federal do Espírito Santo (1976), master's at Pharmacology from Universidade de São Paulo (1980) and doctorate at Pharmacology from Universidade de São Paulo (1981). Has experience in Pharmacology, focusing on Neuropsicopharmacology, acting on the following subjects: ansiedade, coliculo inferior, medo, comportamento defensivo and serotonina. (Source: Lattes Curriculum)
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It is well established that the neural substrates of fear and anxiety are part of an encephalic aversion system (EAS) comprising the amygdala, medial hypothalamus and periaqueductal gray matter. Other structures such as inferior and superior colliculi have also been proposed as components of this system as well as the prefrontal cortex and nucleus accumbens. A sensorimotor gating in these…
The medial hypothalamus, amygdala and dorsal periaqueductal gray (dPAG) and the inferior colliculus (I C) have been grouped together as an "encephalic aversion system" (EAS). The neural substrates responsible for fear and anxiety of these structures translate information of aversive nature in behavioral and emotional adaptive output reactions. Nowadays, it is believed that the EAS possess…
The obsessive-compulsive disorder (OCD) is the fourth most common psychiatric disorder and is related to significant disability, poor quality of life and disrupted family functioning. Despite the existence of effective therapeutic interventions for OCD (e.g. serotonin reuptake inhibitors and behavior psychotherapy), up to half of OCD patients do not respond satisfactorily with treatment. …
(Only some records are available in English at this moment)
Chemical and electrical stimulation of the periaqueductal gray matter (PAG), deep layer of Superior colliculus (dlSC) and the central nucleus of the inferior colliculus (CIC) of rodents cause freezing and escape behavior. Following electrical stimulation of these structures, the animal shows intense flight and explosive behavior. It is believed that the defensive reactions associated with…
Although the inferior colliculus is a structure primarily involved with the processing of acoustic information, it is now widely accepted that it also participates in the integration of sensory, autonomic and behavioral aspects of the defense reaction of animals in dangerous situations. Electrical or chemical stimulation of this structure induces defensive responses such as arousal, freez…
Unconditioned defense reactions observed in mammals are organized by the Brain Aversive System, comprising, among other structures, the dorsal periaqueductal gray matter (dPAG) and inferior colliculus (IC). It has been proposed that the IC is part of the sensorimotor circuitry that processes aversive auditory information and the dPAG is considered the main output of defensive behaviors. B…
(Only some records are available in English at this moment)
Obsessive-compulsive disorder (OCD) is a severe, chronic neurological condition that affects 2-3% of the population. Clinical studies and animal models have confirmed the importance of the serotonergic (5-HT) system in the neurobiology and treatment of OCD. In this context, the 5-HT agonist mCPP exacerbates symptoms in untreated OCD patients and, in rodents, it produces anxiety-like respo…
| 23 / 10 | Completed research grants |
| 37 / 5 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 61 / 16 | All research grants and scholarships |
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CV Lattes
ORCID