CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Davi José de Almeida Moraes in research grants and scholarships supported by FAPESP.
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Heart failure is a public health problem and is one of the leading causes of death worldwide. Despite current advances, the prognosis is poor, and there remains no cure for heart failure. Heart failure is characterised by breathlessness (respiratory irregularities), bronchoconstriction, leg oedema, a progressive loss in cardiac output, left ventricular hypertrophy, sleep apnoea, and raise…
The main goal of this Thematic Project is to study the astrocytic modulation on the synaptic transmission of neurons integral to sympathetic and respiratory networks at the brainstem level under normoxic as well as in hypoxic conditions. This important and contemporary topic in the literature is associated to the role of astrocytes and their gliotransmitters on the modulation of synaptic …
The parasympathetic efferent innervation to the respiratory system controls mainly the contraction of the smooth muscle and mucous secretion in the lower airways. It is well known that the parasympathetic pre-ganglionic motoneurons, that project to the respiratory system, are found in the medulla, specifically in the Nucleus Ambiguus (NA) and in the Dorsal Motor Nucleus of the Vagus (DMV)…
Several studies have demonstrated that glial cells (astrocytes and microglia) are able to modulate the synaptic transmission, affecting the activity of neuronal networks. It is also evident that glial cells are involved in the central generation of respiratory rhythm pattern. The pre-Bötzinger Complex (pre-BötC), a critical site of inspiratory rhythm generation in rodents, contains astroc…
(Only some records are available in English at this moment)
Under resting conditions and from the point of view of thorax and abdomen motor activity, expiration is a passive process that becomes active in situations of high ventilatory demand, such as during hypercapnia/acidosis. In these conditions, phasic motor activity of muscles in the abdominal region is observed, promoting an increase in tidal volume and pulmonary ventilation, favoring the a…
The carotid body (CB) is a peripheral chemoreceptor located in the carotid artery bifurcation, presenting two types of cells: type I (glomus cells) and type II. Glomus cells can detect changes in O2 partial pressure in arterial blood, being organized close to the blood vessels originating from the carotid artery, while type II cells are organized around them, promoting support, and partic…
Expiration, under basal conditions, is a passive phenomenon, whereas, in situations of metabolic challenges such as hypercapnia, expiration becomes active, characterized by increased activity of the abdominal muscles, which favors the exhalation to increase pulmonary ventilation. Several studies have shown that rodents' lateral parafacial region (pFL) generates active expiration during hy…
(Only some records are available in English at this moment)
During basal conditions, breathing in mammals presents passive expiratory phase, with low activity of abdominal muscles. On the other hand, the exercise can recruit these expiratory muscles to produce active expiration. Active expiration in rats is dependent on the activity of neurons called late-Expiratory (late-E) located in the parafacial Respiratory Group (pFRG). During exercise, it i…
The Carotid bodies (CBs) are the main O2 sensors in rats, because it contains cells highly sensitive to reductions in the O2 partial pressure in the arterial blood (hypoxia). During hypoxic conditions, the CBs release neurotransmitters, mainly from the purines family (ATP and adenosine), which act on its metabotropic (P2Y1, P2Y2, A2A, A2B, A1 and A3) and ionotropic (P2X3 and P2X2) recepto…
Hypoxia is a condition of metabolic challenge associated with several physiological and pathological conditions. Among the pathologies, cardiopulmonary diseases stand out, which represent the main cause of death worldwide. Cardiopulmonary changes present in situations of prolonged hypoxia involve the modulation of sympathetic and parasympathetic activities for these systems. Although the …
(Only some records are available in English at this moment)
Cardiorespiratory adaptations to hypoxia are essential for cell survival. The main organs sensitive to O2 in mammals are the carotid bodies (CBs), which are organs highly sensitive to oxygen (O2) and mediate hyperventilation in response to sustained hypoxia (SH). CBs contains glomus cells that express channels for K+ whose inhibition by hypoxia leads to the release of neurotransmitters. T…
Hypertension (high blood pressure) continues to be a major global problem despite an armoury of anti-hypertensive medications. At least 50% of treated hypertensives remain with uncontrolled blood pressure, and this is most likely due to high sympathetic activity, which is not reduced by contemporary anti-hypertensive medication. The carotid body (CB) has emerged as a novel target to lower…
| 2 / 2 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 5 / 5 | Ongoing scholarships in Brazil |
| 9 / 8 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 23 / 21 | All research grants and scholarships |
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