Abstract
The renin angiotensin system activation is implicated on hypertension-induced vascular hypertrophy and endothelial dysfunction. Evidences has suggested that TNF-± cytokine is necessary to angiotensin II-induced cardiac hypertrophy and fibrosis. In addition, TNF-± may to modulate the angiotensin converting enzyme (ACE) activity, but is unknown which TNF-± effects on ACE activity during hy…