Elen Rizzi Sanchez

• Abstract

  The renin angiotensin system activation is implicated on hypertension-induced vascular hypertrophy and endothelial dysfunction. Evidences has suggested that TNF-± cytokine is necessary to angiotensin II-induced cardiac hypertrophy and fibrosis. In addition, TNF-± may to modulate the angiotensin converting enzyme (ACE) activity, but is unknown which TNF-± effects on ACE activity during hy…

  Efects of TNF-alpha inhibition on morphofunctional vascular alterations associated with renovascular hypertension, AP.R

• Abstract

  Mounting evidence have shown the important role of matrix metalloproteinase ((MMP)-2 to the systemic hypertension-induced vascular remodeling. Increased reactive oxygen species (ROS), which are involved with tissue remodelling in many cardiovascular disease, are the key factor to MMP-2 activation in experimental hypertension. At this sense, the reduction of the MMP-2 activity has been imp…

  Effects of curcumin and CH5 curcuminoid on renovascular hypertension-induced matrix metalloproteinase (MMP)-2 and vascular remodeling, BP.IC

• Abstract

  The activation of renin-angiotensin system (RAS) is involved in the complications associated with hypertension as vascular hypertrophy and endothelial dysfunction. The activation of RAS and consequently, increase of Angiotensin II (AngII) occurs in experimental model of hypertension 2-kidney 1-clip (2K1C) . In this sense, 2K1C rats is a good experimental model to evaluate the effects of A…

  Effects of TNF-alfa inhibition on vascular hypertrophy associated with renovascular hypertension, BP.IC

• Abstract

  Hypertension is a health public problem. Inhibitors of angiotensin-converting enzyme (ACE) are widely used for the treatment of hypertension. These effects may be due to decreasing the activation of the renin-angiotensin aldosterone system (RAAS). Evidence has shown that ACE inhibitors (ACEi) are antioxidants through the reduction in the formation of angiotensin II. This peptide may prom…

  Effects of doxycycline on sistemic and vascular angiontensin converting enzyme in experimental hypertension 2K1C, BP.IC

(Only some records are available in English at this moment)