1993 1997 B.S. in Nutrition, Federal University of Mato Grosso, UFMT, Brazil; 1997 1998 Specialization in Public Health, University of Ribeirão Preto, UNAERP, Brazil; 2003 2005 M.S. in Health Sciences, Federal University of Mato Grosso, UFMT, Brazil; 2007 2008 Ph.D. in Biochemistry, University of Barcelona, Spain; 2005 2009 Ph.D. in Medical Clinic University of Campinas, UNICAMP, Brazil; 2009 2011 Postdoctoral Training in Medical Clinic University of Campinas, UNICAMP, Brazil; 2016 - 2017 Visiting Professor Cell Biology Program SickKids Research Institute/Toronto-CA; 2017 2017 Visiting Professor - Université PARIS- DIDEROT 7/França MAIN INTEREST IN RESEARCH - Role of lipid excess (saturated fat acids and interesterified lipids) in the development of obesity and type 2 diabetes. Metabolic and molecular aspects. Significant scientific contributions: - Characterization of the role of high-fat diets in body energy homeostasis and the mechanisms involved in hypothalamic resistance to leptin and insulin. - Identification of TLR4 activation and subsequent induction of endoplasmic reticulum stress as mechanisms involved in hypothalamic resistance to leptin and insulin. Central inhibition of inflammation in DIO animals, by blocking the activation of TLR4 or ER stress was able to reverse the glucose homeostasis in part by inhibition of hepatic glucose production. - Role of hypothalamic autophagy in the regulation of glucose homeostasis induced by obesity - Characterization of the role of interesterified fat in metabolism. Interesterified soybean oil promotes weight, impaired glucose tolerance and increase liver cellular stress markers in Swiss mice. (Source: Lattes Curriculum)
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Obesity represents a serious public health problem and, because it's a chronic multifactorial disease, predisposes the body to a series of diseases, and it is related to increased mortality rate. Also considered a condition where there is activation of low-grade systemic inflammation, obesity is directly related to increased levels of proinflammatory markers, changes in intestinal permeab…
Obesity is a disease characterized by the excess of adipose tissue, which compromises health and have become a health global issue in the last decades. Changes in the dietary pattern, associated with the intake of foods with elevated energy density, containing significant amounts of saturated, trans and interesterified fat, associated with a decrease in physical activity levels are major …
Lipids are essential for the human body, participating in important functions such as energy storage, cell signaling, formation of steroid hormones, cell structures and other functions essential to life. However, fats have been excessively used in the contemporary diet, especially in processed and ultra-processed industrialized products, whose consumption is associated with metabolic diso…
Recently, interesterified fat has been used as an alternative to the use of trans fats. The interesterified fat is obtained by processing vegetable oils using chemical or enzymatic methods, which results in rearranging in the fatty acids of the glycerol molecule, without changing the degree of saturation thereof. Recent studies have shown adverse metabolic effects in response to chronic f…
Obesity represents a serious public health problem and, because it is a chronic multifactorial disease, predisposes the organism to a series of diseases and is related to the increase of the mortality rate. Also considered a condition where there is activation of low-grade systemic inflammation, obesity is directly related to the increase of levels of pro-inflammatory markers, changes in …
The actual dietary pattern is characterized by high consumption of processed food which contains high content of lipids, including trans fatty acids. The excess of these type of fatty acids in the diet can rise LDL-c levels and is related to coronary diseases and diabetes. Nowadays, interesterified fats have been used as an alternative to substitute the trans fat once this was proved to b…
Obesity is a disease characterized by excess body fat that compromises health and has become a global public health problem in developed and in the development countries. One of the main aspects related to obesity is the presence of chronic low-grade inflammation that culminates in many disorders, including the loss of control on food intake by a small region of the central nervous system…
In the last years, it has been occurring on a global scale a startling increase in the number of individuals with obesity, a pathology characterized by the abnormal accumulation of fat that can lead to health risks. The pathogenesis of obesity consists, predominantly, in the loss of the energetic homeostasis that has as a determining factor the dysfunction of the hypothalamus, a region of…
(Only some records are available in English at this moment)
The consumption of fatty acids seems to be an important factor for the development and progression of obesity. Recently, studies have shown that a crucial process for maintaining the functionality of hypothalamic neurons and subsequent control of body energy balance known as autophagy appears to be involved in the pathogenesis of obesity. Autophagy is a catabolic process, which aims to ma…
During the last decades, studies of different dietary fatty acids have been carried out to understand the effect of fat intake on risk markers for obesity and associated disease. The overconsumption of dietary fats leads to diet-induced activation of inflammatory pathways which is implicated in driving aspects of metabolic dysfunction, including the development of obesity and insulin resi…
Energy homeostasis involves a complex balance between the neuroendocrine system, located in the medial basal hypothalamus region of the brain, and signals from peripheral organs being important regulators of this communication. During the development of obesity, this system is often compromised by specific insults, including lipotoxicity and release of inflammatory mediators by glia cells…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 2 / 1 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 7 / 6 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 18 / 16 | All research grants and scholarships |
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CV Lattes
ORCID