bachelor's at Ciências Biológicas from Universidade Presbiteriana Mackenzie (1992), master's at Morphology from Universidade Federal de São Paulo (1995) and doctorate at Morphology from Universidade Federal de São Paulo (2001). Has experience in Morphology, focusing on Morphology, acting on the following subjects: espermatogênese, morfometria, testículo, cimetidina and apoptose. (Source: Lattes Curriculum)
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ACE2 and TMPRSS2 proteins allow the SARS-CoV-2 virus entry into the host cells, inducing Covid-19- associated respiratory distress syndrome. Besides lung cells, these proteins are also found in salivary glands, testes and epididymis. Saliva is a common medium for virus transmission, and the salivary gland is a site of viral infection, replication and transmission. Studies have demonstrat…
Depression has affected million people worldwide and the antidepressant drugs, such as selective serotonin-norepinephrine reuptake inhibitors (SNRIs), have been clinically prescribed. Male patients treated with venlafaxine, a SNRI, has demonstrated reduced serum testosterone levels and erectile and ejaculatory dysfunctions. However, studies about the effect of venlafaxine on the histophys…
Cimetidine has been used for the treatment of digestive cancer due to its antagonist effect on the histamine H2 receptors since histamine acts as growth factor for different tumoral cell types via H2 receptors. Moreover, the tumoral growth inhibition seems to be related to the antiangiogenic effect of cimetidine. In the male reproductive system, cimetidine has caused harmful effects mainl…
(Only some records are available in English at this moment)
The k18-hACE2 transgenic mice that express human ACE2, an essential protein for the infection of host cell by SARS-CoV-2, has been used to investigate the impact of the viral infection. The epididymis, an essential organ for male fertility, is responsible for spermatozoa maturation and protection of these cells against pathogens. The epithelial and stromal cells exert immunological respon…
The ACE2 and TMPRSS2 proteins allow the entry of the SARS-CoV-2 Virus into the host cell, causing COVID-19, a severe acute respiratory syndrome. In addition to lung cells, these proteins are present at considerable levels in testicular cells. Some studies have demonstrated the presence of the virus in the semen as well as low levels of testosterone and testicular alterations in patients w…
Saliva, produced by Salivary Glands (SGs), is a secretory product composed of several components, which are essential for the structural and functional maintenance of the oral cavity. Among the salivary components, SGs produce epidermal growth factor (EGF), an important factor for oral mucosa regeneration, and the V-ATPase, a proton pump that maintains the salivary pH. Surrounding the gla…
In December 2019, the first case of the new coronavirus SARS-CoV-2 was detected in Wuhan, and the virus has spread through the world, causing a fatal disease named COVID-19. Viruses can spread through small droplets of saliva, a common and transient medium for viral transmission. Thus, studies have demonstrated that the salivary glands are important organs involved in infection, replicati…
COVID-19, a disease induced by SARS-CoV-2 virus, is a serious respiratory disease responsible for the pandemic declared by the World Health Organization in 2020. A transgenic mice (K18-hACE2) expressing the human ACE2, an essential protein that mediates viral entry into host cells, was created as a model of study to investigate the impact of COVID-19 in the organism. The epididymal cells …
(Only some records are available in English at this moment)
The global pandemic COVID-19, caused by SARS-CoV-2, lead to millions of deaths worldwide, and studies have shown that men were more susceptible to infection. The epididymis is an essential organ for male fertility since the specialized luminal environment provides sperm motility and fertilizing capacity. Clear cells, one of the most abundant cells in the epididymis, regulate the luminal f…
Background: The research group of Dr. Hinton's laboratory has been investigating molecular mechanisms involved in the control of Wolffian duct (WD)/epididymis morphogenesis, which in turn is necessary for normal male fertility. Recently, this group has demonstrated the presence of periostin within the extracellular matrix (ECM) surrounding the developing WD and has been hypothesized to re…
| 1 / 1 | Ongoing research grants |
| 5 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 21 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 1 / 1 | Completed scholarships abroad |
| 31 / 27 | All research grants and scholarships |
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CV Lattes
ORCID