CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Odontologia (FOAr) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Ciências Biológicas from Universidade Presbiteriana Mackenzie (1992), master's at Morphology from Universidade Federal de São Paulo (1995) and doctorate at Morphology from Universidade Federal de São Paulo (2001). Has experience in Morphology, focusing on Morphology, acting on the following subjects: espermatogênese, morfometria, testículo, cimetidina and apoptose. (Source: Lattes Curriculum)
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ACE2 and TMPRSS2 proteins allow the SARS-CoV-2 virus entry into the host cells, inducing Covid-19- associated respiratory distress syndrome. Besides lung cells, these proteins are also found in salivary glands, testes and epididymis. Saliva is a common medium for virus transmission, and the salivary gland is a site of viral infection, replication and transmission. Studies have demonstrat…
Depression has affected million people worldwide and the antidepressant drugs, such as selective serotonin-norepinephrine reuptake inhibitors (SNRIs), have been clinically prescribed. Male patients treated with venlafaxine, a SNRI, has demonstrated reduced serum testosterone levels and erectile and ejaculatory dysfunctions. However, studies about the effect of venlafaxine on the histophys…
(Only some records are available in English at this moment)
The epididymis plays a crucial role in male fertility. During the passage along the epididymis, spermatozoa, newly released from the testis, acquire ability to fertilize the oocyte. This organ consists of a single highly convoluted duct divided into four main anatomical regions: the initial segment, head, body, and tail. The latter region is important for the final maturation, storage, an…
The k18-hACE2 transgenic mice that express human ACE2, an essential protein for the infection of host cell by SARS-CoV-2, has been used to investigate the impact of the viral infection. The epididymis, an essential organ for male fertility, is responsible for spermatozoa maturation and protection of these cells against pathogens. The epithelial and stromal cells exert immunological respon…
The ACE2 and TMPRSS2 proteins allow the entry of the SARS-CoV-2 Virus into the host cell, causing COVID-19, a severe acute respiratory syndrome. In addition to lung cells, these proteins are present at considerable levels in testicular cells. Some studies have demonstrated the presence of the virus in the semen as well as low levels of testosterone and testicular alterations in patients w…
Saliva is essential for lubrication, digestion, protection against pathogens, and maintenance of acid-base balance. Diacerein, an anti-inflammatory agent that inhibits pro-inflammatory cytokines such as TNF-± and IL-1², has been clinically used in cases of osteoarthritis. The detrimental effects of diacerein on the testicular function of rodents, under normal conditions, have been reporte…
Saliva, produced by Salivary Glands (SGs), is a secretory product composed of several components, which are essential for the structural and functional maintenance of the oral cavity. Among the salivary components, SGs produce epidermal growth factor (EGF), an important factor for oral mucosa regeneration, and the V-ATPase, a proton pump that maintains the salivary pH. Surrounding the gla…
In December 2019, the first case of the new coronavirus SARS-CoV-2 was detected in Wuhan, and the virus has spread through the world, causing a fatal disease named COVID-19. Viruses can spread through small droplets of saliva, a common and transient medium for viral transmission. Thus, studies have demonstrated that the salivary glands are important organs involved in infection, replicati…
(Only some records are available in English at this moment)
The global pandemic COVID-19, caused by SARS-CoV-2, lead to millions of deaths worldwide, and studies have shown that men were more susceptible to infection. The epididymis is an essential organ for male fertility since the specialized luminal environment provides sperm motility and fertilizing capacity. Clear cells, one of the most abundant cells in the epididymis, regulate the luminal f…
Background: The research group of Dr. Hinton's laboratory has been investigating molecular mechanisms involved in the control of Wolffian duct (WD)/epididymis morphogenesis, which in turn is necessary for normal male fertility. Recently, this group has demonstrated the presence of periostin within the extracellular matrix (ECM) surrounding the developing WD and has been hypothesized to re…
| 6 / 5 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 22 / 19 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 33 / 29 | All research grants and scholarships |
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