graduate at Ciências Biológicas from Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (1990), master's at Ciências Biológicas Área Genética from Faculdade de Medicina de Ribeirão Preto (1993) and ph.d. at Ciências Biológicas Área de Genética from Faculdade de Medicina de Ribeirão Preto (1997). Associated Professor. Has experience in Genetics, focusing on Mutagenesis, acting on the following subjects: aberrações cromossômicas, antioxidantes, cisplatina, mutagênese and antimutagênese. (Source: Lattes Curriculum)
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The consumption of nutraceuticals is considered a strategy in cancer prevention, and the possible mechanisms of action include cell signaling pathways, cell cycle, modulation of redox balance, induction of DNA damage, epigenetic mechanisms and anti-angiogenesis. The data from the association between nutraceuticals showed that acting together can result in synergistic actions, with better …
The transformation of a normal cell into a cancerous phenotype requires stages of initiation, progression, and promotion by altering specific genes. Although predisposition to cancer cannot be signaled out by a single factor, a group of factors place some individuals at a higher risk of acquiring the disease. As determined by epidemiological studies, the predominant forms of cancer are br…
The use of the 3Rs (Reduction, Refinement, and Replacement) was proposed as an alternative for replacing the use of animals in research in order to minimize the number of animals used and to refine the experimental design so as to cause the least possible amount of pain. The importance of applying new alternative methods to the use of animals has led to the creation of new in vitro method…
(Only some records are available in English at this moment)
Colorectal cancer (CCR) is the second type of cancer with higher mortality and high incidence rates in recent decades. The development of adverse effects and drug resistance necessitates the need to develop alternative treatments to traditional therapy. One of the treatments is the use of nutraceuticals, compounds present in natural products that regulate various metabolic pathways and ca…
Colorectal cancer (CRC) is one of the most common cancers and it represents about 10% of incidence and 9.4% of global cancer mortality, according to data released in 2020. The progress in treatment of CRC with chemotherapeutics drugs in the last 70 years was very limited, and the therapy with 5-fluorouracil still represents the bases of chemotherapy in many clinical protocols, including t…
Cancer is a genetic disease characterized by uncontrolled cell division. Bioactive compounds found in plants, known as phytochemicals, can act as chemopreventive/chemotherapeutic agents in cancer, with more than 20,000 different phytochemicals with potential antitumor effects found in fruits and vegetables. Extracts obtained from seeds and bark of fruit species are increasingly studied fo…
Hepatocellular Carcinoma is one of the most common Cancers in adults. Sorafenib is the only drug available in the clinic in advanced stages, but many patients exhibit tumor progression during chemotherapy, which leads to the search for new treatments. The occurrence of the disease may be reduced and/or its development controlled by synergistic mechanisms in combination with diet bioactive…
(Only some records are available in English at this moment)
The jabuticabeira is a native Brazilian fruit species, and there is great economic andtechnological interest in this plant due to its nutritional and functional properties.Jabuticaba seeds have been shown to be the richest source of phenolic compounds, andthe pulp still represents the main product of industrial interest; jabuticabeira leaves arestill neglected due to the lack of knowledge…
Cancer is a growing problem for human health worldwide. The occurrence of cancer is related to population aging, as well as the prevalence of risk factors. Epigenetic and genetic alterations contribute to cancer initiation and progression. Epigenetics is a non-Mendelian inheritance of DNA modifications, which, do not affect the DNA base sequence, but may influence the expression of genes.…
Studies have demonstrated that the maternal undernutrition or overnutrition may be associated with increased risk of different diseases in the offsprings, such as diabetes, obesity, hypertension and cardiovascular disorders. Vitamin B6, a water-soluble vitamin, is involved in many reactions including DNA, homocysteine and one-carbon metabolisms. Moreover, vitamin B6 plays an important rol…
In the last decade, significant advances have been achieved with regard to the effort to decipher the molecular mechanisms responsible for the impact of nutritional factors in gene regulation, especially pertaining to processes that do not involve the modification of the genetic code. With the elucidation of the mechanisms controlling epigenetic events, such as DNA methylation, acetylatio…
| 9 / 7 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 20 / 18 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 34 / 30 | All research grants and scholarships |
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CV Lattes
ORCID