graduate at Ciências Biológicas from Faculdade de Filosofia Ciências e Letras de Ribeirão Preto (1990), master's at Ciências Biológicas Área Genética from Faculdade de Medicina de Ribeirão Preto (1993) and ph.d. at Ciências Biológicas Área de Genética from Faculdade de Medicina de Ribeirão Preto (1997). Associated Professor. Has experience in Genetics, focusing on Mutagenesis, acting on the following subjects: aberrações cromossômicas, antioxidantes, cisplatina, mutagênese and antimutagênese. (Source: Lattes Curriculum)
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The consumption of nutraceuticals is considered a strategy in cancer prevention, and the possible mechanisms of action include cell signaling pathways, cell cycle, modulation of redox balance, induction of DNA damage, epigenetic mechanisms and anti-angiogenesis. The data from the association between nutraceuticals showed that acting together can result in synergistic actions, with better …
The transformation of a normal cell into a cancerous phenotype requires stages of initiation, progression, and promotion by altering specific genes. Although predisposition to cancer cannot be signaled out by a single factor, a group of factors place some individuals at a higher risk of acquiring the disease. As determined by epidemiological studies, the predominant forms of cancer are br…
The use of the 3Rs (Reduction, Refinement, and Replacement) was proposed as an alternative for replacing the use of animals in research in order to minimize the number of animals used and to refine the experimental design so as to cause the least possible amount of pain. The importance of applying new alternative methods to the use of animals has led to the creation of new in vitro method…
Nutritional deficiency during the embryonic period is a health problem in many populations. It is known that the lack of nutrients in pregnancy is one of the mechanisms that can influence the health of both mother and newborn. During the reproductive process, the genome of mammals undergoes a profound reprogramming of methylation patterns in germ cells and in the early stages of pre-impla…
(Only some records are available in English at this moment)
Hepatocellular Carcinoma is one of the most common Cancers in adults. Sorafenib is the only drug available in the clinic in advanced stages, but many patients exhibit tumor progression during chemotherapy, which leads to the search for new treatments. The occurrence of the disease may be reduced and/or its development controlled by synergistic mechanisms in combination with diet bioactive…
Underlying the hallmarks of cancer are genomic instability and epigenetic mechanisms that influence the expression of genes related to the maintenance of genomic stability. Among the epigenetic mechanisms, DNA methylation is the most studied and relevant. Cancer incidence depends on interactions between genome and epigenome that together interact with environmental factors including diet.…
Previously used for the treatment of hypotension as well as ocular decongestant, synephrine is a proto-alkaloid that is naturally found in the immature fruit orpeelof Citrus aurantium (bitter orange) and widely used in dietary supplements aimed weight loss and improvement sports performance. Studies about clinical effects of synephrine as hypertension and tachycardia have been described f…
(Only some records are available in English at this moment)
Cancer is a growing problem for human health worldwide. The occurrence of cancer is related to population aging, as well as the prevalence of risk factors. Epigenetic and genetic alterations contribute to cancer initiation and progression. Epigenetics is a non-Mendelian inheritance of DNA modifications, which, do not affect the DNA base sequence, but may influence the expression of genes.…
Studies have demonstrated that the maternal undernutrition or overnutrition may be associated with increased risk of different diseases in the offsprings, such as diabetes, obesity, hypertension and cardiovascular disorders. Vitamin B6, a water-soluble vitamin, is involved in many reactions including DNA, homocysteine and one-carbon metabolisms. Moreover, vitamin B6 plays an important rol…
In the last decade, significant advances have been achieved with regard to the effort to decipher the molecular mechanisms responsible for the impact of nutritional factors in gene regulation, especially pertaining to processes that do not involve the modification of the genetic code. With the elucidation of the mechanisms controlling epigenetic events, such as DNA methylation, acetylatio…
| 1 / 1 | Ongoing research grants |
| 8 / 6 | Completed research grants |
| 18 / 16 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 30 / 26 | All research grants and scholarships |
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CV Lattes
ORCID