CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Undergraduation on Biomedical Sciences - Faculdade Medicina de Ribeirão Preto Usp (1978). Master degree in Physiology from Universidade de São Paulo (1981) and PhD in Genetics from Universidade Federal do Rio de Janeiro (1985). Research interests on molecular genetics and control of gene expression in Leishmania. (Source: Lattes Curriculum)
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| An agenda for forgotten diseases |
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Leishmaniasis is a devastating parasitic disease that targets the poorest of society and is the 9th largest global infectious disease burden (WHO). It is truly a Neglected Infectious Disease as the combined financial support of basic and clinical research equates to <2% of infectious disease R&D resources available. Consequently, there are no vaccines available currently and the limited a…
Species of Leishmania threaten 350 million people worldwide on four continents. New treatments and vaccines are desperately needed and the UK and Brazilian governments are committed to the World Health Organization’s recent call to further support Neglected Tropical Disease research. The single-cell Leishmania parasite differentiates in distinct forms during its lifecycle to adapt to diff…
The Leishmaniases are the ninth largest disease burden amongst infectious diseases and the second biggest killer of parasitic diseases, threatening one tenth of the world's population. Who estimates 0.7-1.2 million new cases of cutaneous Leishmaniases annually while visceral Leishmaniasis infects 200,000-400,000 killing 10-20% of them. Brazil is stricken by all pathologies of this disease…
(Only some records are available in English at this moment)
Parasites of the genus Leishmania spp are responsible for the complex of neglected tropical and subtropical diseases called leishmaniasis. In Brazil, Leishmania (Viannia) braziliensis is the main etiological agent of the tegumentary form of the disease. During its life cycle, the protozoan alternates between hostile and diverse environments : the digestive system of the insect vector and …
The family Trypanosomatidae comprises a group of protozoan parasites that branched early during the evolution of eukaryotes. Among the trypanosomatids, parasites from the genera Trypanosoma (causative agents of Sleeping Sickness and Chagas Disease) and Leishmania (causative agents of Leishmaniases) are the most recognised. Different from most eukaryotes, trypanosomatids present polycistro…
Control of gene expression in Leishmania occurs mainly at the post-transcriptional level. Central to the regulatory complexes are cis and trans-regulatory elements, mainly represented by mRNA elements (cis elements) and RNA binding proteins (RBPs), and may include hitherto unexplored content of noncoding transcripts (ncRNAs) recently detected in these parasites. We have previously demonst…
The protozoan parasite Leishmania, besides its medical relevance, has peculiar genetic features including the polycistronic nature of the transcriptional process and the implicated differences on regulation of gene expression, that happens mainly at the posttranscriptional level. Thus, RNA Binding Proteins play a central role in modulating gene expression in these organisms; the interacti…
During its life cycle, the digenetic parasite Leishmania colonizes hostile environments with different physiological characteristics, requiring precision in the modulation of gene expression. Its genetic organization with peculiar characteristics, such as the lack of canonical promoters for RNA Polymerase II, the transcription of unrelated genes in polycistronic units, and the processing …
(Only some records are available in English at this moment)
During its lifecycle Leishmania needs to have a rapid shift in gene expression profile in order to adapt to environmental changes. Trypanosomatids lack canonical promoters for most of their genes and thus, regulation of gene expression results mostly from post-transcriptional processes. Differentially expressed (DE) non-protein coding RNAs (ncRNAs) have been identified in the transcriptom…
The discovery of non-coding RNAs (ncRNAs) that act as regulatory elements has significantly contributed to the development and control of many aspects from cellular and molecular points of view. In Leishmania protozoa, ncRNAs are still poorly explored, particularly at the functional level. The genetic organization of these parasites transfer to the post-transcriptional level the control o…
Protein aRginine MethylTransferases (PRMTs) are important regulators of gene expression in Leishmania spp. These enzymes can target relevant regulatory elements at the posttranscriptional level, such as RNA binding proteins. Previous work in our laboratory has shown that PRMT7 in Leishmania major plays an important role in parasite virulence in vivo. Additionally, the fact that this enzym…
Leishmania Viannia braziliensis is the major ethiological agent of cutaneous leishmaniasis in Brazil and the species associated with the mucosal form of the disease which affects about 5% of patients and leads to progressive destruction of mucosal, cartilage or bones of the face, pharynx and larynx. Working with two paired mucosal (LbrM) and cutaneous (LbrC) L. braziliensis isolates, we d…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 22 / 12 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 65 / 24 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 4 / 4 | Completed scholarships abroad |
| 96 / 45 | All research grants and scholarships |
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