CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Undergraduation on Biomedical Sciences - Faculdade Medicina de Ribeirão Preto Usp (1978). Master degree in Physiology from Universidade de São Paulo (1981) and PhD in Genetics from Universidade Federal do Rio de Janeiro (1985). Research interests on molecular genetics and control of gene expression in Leishmania. (Source: Lattes Curriculum)
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| An agenda for forgotten diseases |
| More itemsLess items |
| News published in Agência FAPESP Newsletter about the researcher |
| More itemsLess items |
| TITULO |
| Articles published in other media outlets ( ): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
The protozoan Leishmania, etiological agent of diseases of indisputable medical importance, has peculiar forms of genome organization and expression. The aim of this proposal is to investigate key elements of genetic variability and post-transcriptional regulation of gene expression. In specific lines of investigation, we will study genome variation in response to DNA replication stress; …
The protozoan Leishmania, etiological agent of diseases of indisputable medical importance, has peculiar forms of genome organization and expression. The aim of this proposal is to investigate key elements of genetic variability and post-transcriptional regulation of gene expression. In specific lines of investigation, we will study genome variation in response to DNA replication stress; …
Leishmaniasis is a devastating parasitic disease that targets the poorest of society and is the 9th largest global infectious disease burden (WHO). It is truly a Neglected Infectious Disease as the combined financial support of basic and clinical research equates to <2% of infectious disease R&D resources available. Consequently, there are no vaccines available currently and the limited a…
Species of Leishmania threaten 350 million people worldwide on four continents. New treatments and vaccines are desperately needed and the UK and Brazilian governments are committed to the World Health Organization’s recent call to further support Neglected Tropical Disease research. The single-cell Leishmania parasite differentiates in distinct forms during its lifecycle to adapt to diff…
(Only some records are available in English at this moment)
Protozoa of the genus Leishmania cause a group of neglected diseases known as leishmaniasis, and the study of these parasites is essential for identifying potential therapeutic targets. During its life cycle, this organism goes through distinct environments such as the gut of the phlebotomine vector and the cells of the immune system of the mammalian host. Thus, necessary aspects for its …
In addition to their medical relevance, Leishmania parasites as early-branched organisms are excellent models for studying genetic and biochemical processes. The peculiarities of its genetic organization are remarkable; their genes are organized into long sets of directional clusters, and structural and functional polycistrons. There are no canonical promoters to control RNA polymerase II…
(Only some records are available in English at this moment)
Parasites of the genus Leishmania spp are responsible for the complex of neglected tropical and subtropical diseases called leishmaniasis. In Brazil, Leishmania (Viannia) braziliensis is the main etiological agent of the tegumentary form of the disease. During its life cycle, the protozoan alternates between hostile and diverse environments : the digestive system of the insect vector and …
The protozoan parasite Leishmania, besides its medical relevance, has peculiar genetic features including the polycistronic nature of the transcriptional process and the implicated differences on regulation of gene expression, that happens mainly at the posttranscriptional level. Thus, RNA Binding Proteins play a central role in modulating gene expression in these organisms; the interacti…
(Only some records are available in English at this moment)
During its lifecycle Leishmania needs to have a rapid shift in gene expression profile in order to adapt to environmental changes. Trypanosomatids lack canonical promoters for most of their genes and thus, regulation of gene expression results mostly from post-transcriptional processes. Differentially expressed (DE) non-protein coding RNAs (ncRNAs) have been identified in the transcriptom…
The discovery of non-coding RNAs (ncRNAs) that act as regulatory elements has significantly contributed to the development and control of many aspects from cellular and molecular points of view. In Leishmania protozoa, ncRNAs are still poorly explored, particularly at the functional level. The genetic organization of these parasites transfer to the post-transcriptional level the control o…
Protein aRginine MethylTransferases (PRMTs) are important regulators of gene expression in Leishmania spp. These enzymes can target relevant regulatory elements at the posttranscriptional level, such as RNA binding proteins. Previous work in our laboratory has shown that PRMT7 in Leishmania major plays an important role in parasite virulence in vivo. Additionally, the fact that this enzym…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing grants |
| 23 / 13 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 68 / 27 | Completed scholarships in Brazil |
| 5 / 5 | Completed scholarships abroad |
| 104 / 53 | All research grants and scholarships |
| Associated processes | |