- Research Grants
graduate at Medicina from Universidade de Santo Amaro (1987) and ph.d. at Endocrinology from Universidade de São Paulo (1997). Has experience in Medicine, focusing on Clinical Medicine, acting on the following subjects: deficiência da 21-hidroxilase, 21-hidroxilase, hiperplasia adrenal congênita, adrenal and 17ohp. (Source: Lattes Curriculum)
Introduction: CAH is an autosomal recessive disease with significant morbi/mortality and high prevalence. Clinical picture may vary from the external genitalia virilization in girls, culminating with errors of sex determination, to hyponatremic dehydration and shock in the first days of life. Recently, CAH-NBS was included in 9 Brazilian states, and Nationwide coverage is scheduled unti...
21-hydroxylase deficiency (21OHD) is a common autosomic recessive disorder characterized by a great phenotypic variability, from prenatal external genitalia virilization in female fetuses to the hirsutism at adulthood, with the possibility the coexistence of a serious aldosterone deficiency that could cause hyponatremic dehydration in the neonatal period. These clinical forms are caused...
Human growth and development represent a sequential process, during which the fertile egg reaches the adult state. Growth is characterized by the balanced cellular multiplication, whereas development is mainly characterized by cellular differentiation. In the present project, we will analyze different genes in clinical syndromes implicated in human growth and development. In the growth ...
(Only some records are available in English at this moment)
Ninety percent of the Congenital Adrenal Hyperplasia (CAH) cases present the 21-hydroxylase deficiency resulting in an impaired Cortisol secretion and, in some cases an impaired aldosterone secretion. Then, an increased production of steroid precursors occurs secondary to ACTH accumulation by missing negative feedback in the Pituitary gland. In the Adrenal, these precursors are deviate...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
GOMES, Larissa Garcia. Estudo da proteína P450 óxido-redutase e dos citocromos hepáticos 2C19 e 3A4 como possíveis moduladores do fenótipo da deficiência da 21-hidroxilase. 2009. 90f. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (05/55364-0)
MOURA, Vivian de Oliveira. Análise de genes moduladores do fenótipo da forma não clássica da deficiência da 21-hidroxilase. 2011. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (08/51624-6)
KAUPERT, Laura Cesar. Análise de genes moduladores do fenótipo de virilização genital em mulheres com a forma clássica da deficiência da 21-hidroxilase. 2012. Tese (Doutorado) – Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (08/55546-0)