Bachelor's at Ciências Biológicas from Universidade Presbiteriana Mackenzie (1993), master's at Pharmacology from Universidade Federal de São Paulo (1997) and doctorate at Clinical Medicine from Universidade Estadual de Campinas (2002). Has experience in Physiology, focusing on Endocrinal Physiology, acting on the following subjects: insulin resistance, oxidative stress, pancreatic islet (Source: Lattes Curriculum)
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Diabetes mellitus type 2 (DM2) is the metabolic disease more prevalent throughout the world and is characterized by chronic hyperglycemia with disorder in the metabolism of carbohydrates, fats and proteins, resulting from defects in insulin secretion, action or both. The pathophysiology of DM2 has been primarily associated with the increase in inflammatory sub-clinic framework and develop…
We intend to further study the role of NAD(P)H oxidase in the physiology and pathophysiology of insulin-secreting cells. The high point of this project will be the implementation of more advanced research methods in order to access information not yet available and thus, confirm which free radical is produced and in which cytosolic compartment. Therefore, we will use genetically modified …
Diabetes mellitus (DM) is characterized as a metabolic syndrome with multiple origins, which results from a deficiency in the production of insulin and/or its action, and which culminates in hyperglycemia. The pancreatic beta cells are responsible for the production of insulin in the body under proper physiological conditions. However, in diabetic individuals, there is a physiological imb…
It's known that the glucose-induced insulin secretion can be followed by the increase of reactive oxygen species (ROS) which can partly be attributed to the action of the NAD(P)H oxidase enzyme. It has been demonstrated that pancreatic islet cells express the components of NAD(P)H oxidase, which takes part in the insulin secretion process induced by glucose. Many studies have been demonst…
Diabetes Mellitus is a heterogeneous group of metabolic diseases characterized by hyperglycemia. In the most common form of the disease, type 2, the etiologies are not yet established. There is a genetic component, yet ill-defined and obesity, physical inactivity and aging trigger or accelerate the onset of the disease. DM2 appears to be polygenic, with polymorphisms that should facilitat…
Insulin plays a central role in the regulation of glucose homeostasis and acts in a coordinated cellular events that regulate the metabolic and growth, so when we consider situations of insulin resistance, we must do not take into account only the metabolism of glucose. Insulin resistance is considered the main pathophysiological feature of metabolic syndrome that is defined by a set of a…
| 5 / 2 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 7 / 3 | Completed scholarships in Brazil |
| 13 / 6 | All research grants and scholarships |
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CV Lattes
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