- Research Grants
graduation at Ciências Biológicas Bacharelado from Universidade Metodista de São Paulo (1999), graduation at Ciências Biológicas Licenciatura from Universidade Metodista de São Paulo (1999), master's at Pharmacology from Universidade de São Paulo (2002) and doctorate at Physiology from Universidade de São Paulo (2006). Has experience in , focusing on Biological Sciences, acting on the following subjects: diabetes mellitus, neutrophils, neutrófilos, phagocytosis and doença arterial. (Source: Lattes Curriculum)
|News published in Agência FAPESP Newsletter about the researcher|
|Cellular alterations increase the vulnerability of obese and diabetic individuals to infections|
Several epigenetic factors, such as excessive consumption of calories through fast food, reduced fiber intake and sedentary lifestyle, and psychosocial factors, including the decrease in sleep duration and depression are contributing to the increasing incidence of diabetes mellitus type 2 both in Brazilian population as the world. Whereas diabetic patients had a worsened prognosis infla...
Reactive oxygen species (ROS) primarily produced via NADPH oxidase play an important role for killing microorganisms in neutrophils. In this study we examined if ROS production in Human promyelocytic leukemia cells (HL60) differentiated into neutrophil-like cells (dHL60) induces ER stress and activates the unfolded protein response (UPR). To cause ROS production cells were treated with ...
Obesity represents a serious public health problem. This pathological condition is associated with high morbidity and mortality, which is explained by its association with chronic diseases such as hypertension, dyslipidemia and type 2 diabetes mellitus (DM2). Obesity promotes a low-grade chronic inflammatory state, which is involved in dysfunction of various organs and tissues such as p...
(Only some records are available in English at this moment)
Nowadays, the ER stress has been investigated in cell death process. This cellular compartment can be under stress condition because of protein formation alterations,can participate in ROS production, as well as NADPH oxidase and mitochondria, and promote a reaction cascate from reticulum stress. The aim of this project is to investigate the participation of ER stress in cell death proc...
Neutrophils are phagocytic cells that act on the first line of defense against invading microorganisms. These cells have an important role in initiating and sustaining the inflammatory process, and contribute in the regulation of immune reactions. In some pathological conditions, various functions of neutrophils are impaired, which causes a greater susceptibility of inflammation and com...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
KUWABARA, Wilson Mitsuo Tatagiba. Participação do estresse de retículo endoplasmático no processo de morte celular em neutrófilos de ratos diabéticos.. 2013. Dissertação (Mestrado) - Instituto de Ciências Biomédicas. Universidade de São Paulo (USP). São Paulo. (10/12818-0)