Tatiana Carolina Alba Loureiro

• Abstract

  Several epigenetic factors, such as excessive consumption of calories through fast food, reduced fiber intake and sedentary lifestyle, and psychosocial factors, including the decrease in sleep duration and depression are contributing to the increasing incidence of diabetes mellitus type 2 both in Brazilian population as the world. Whereas diabetic patients had a worsened prognosis inflamm…

  The role of neutrophils in the inflammatory response during type 2 Diabetes mellitus: cellular and molecular mechanisms, AP.R

• Abstract

  Reactive oxygen species (ROS) primarily produced via NADPH oxidase play an important role for killing microorganisms in neutrophils. In this study we examined if ROS production in Human promyelocytic leukemia cells (HL60) differentiated into neutrophil-like cells (dHL60) induces ER stress and activates the unfolded protein response (UPR). To cause ROS production cells were treated with PM…

  NADPH oxidase-dependent production of reactive oxygen species induces endoplasmatic reticulum stress in neutrophil-like HL60 cells, PUB.ART

• Abstract

  Obesity represents a serious public health problem. This pathological condition is associated with high morbidity and mortality, which is explained by its association with chronic diseases such as hypertension, dyslipidemia and type 2 diabetes mellitus (DM2). Obesity promotes a low-grade chronic inflammatory state, which is involved in dysfunction of various organs and tissues such as pan…

  Effect of tributyrin, pro-drug of butyrate, on insulin resistance associated to obesity, AP.R

(Only some records are available in English at this moment)

• Characterization of epigenetic biomarkers of type 2 diabetes mellitus: identification of potential therapeutic targets of n-3 polyunsaturated fatty acids, BP.TT

• Abstract

  Nowadays, the ER stress has been investigated in cell death process. This cellular compartment can be under stress condition because of protein formation alterations,can participate in ROS production, as well as NADPH oxidase and mitochondria, and promote a reaction cascate from reticulum stress. The aim of this project is to investigate the participation of ER stress in cell death proces…

  The role of ER stress in cell death of neutrophils from diabetic rats, BP.MS

• Abstract

  Neutrophils are phagocytic cells that act on the first line of defense against invading microorganisms. These cells have an important role in initiating and sustaining the inflammatory process, and contribute in the regulation of immune reactions. In some pathological conditions, various functions of neutrophils are impaired, which causes a greater susceptibility of inflammation and compl…

  Possible evidences of ER and mitochondria participation in neutrophil HL-60 differentiated death under hyperglycemia condition, BE.EP.MS