CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Instituto de Biologia (IB) (Institutional affiliation for the last research proposal) Birthplace: Brazil
Nurse bachelor at Universidade Estadual de Campinas, Unicamp (1985), master in Biochemistry at Unicamp (1988) and Ph.D in Biochemistry at Universidade de São Paulo (1993); Full professor in Biochemistry, Unicamp (2010). Has experience in Byophysics, Biochemistry and pharmacy, focusing on Drug delivery and Biomimetic systems, focusing the interaction of active molecules (local anesthetics, anticancer drugs) with carriers such as liposomes, nanostructured lipid carriers, cyclodextrins). (Source: Lattes Curriculum)
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Nanostructured lipid carriers (CLN) are suitable for the encapsulation of hydrophobic drugs, offering a series of advantages over other drug-delivery carriers such as: biocompatibility, biodegradability, non-immunogenicity, relative low cost, no requirement of organic solvents and scalability. Aiming to stablish a collaborative research network between the Biomembranes laboratory (Unicamp…
The aim of this project is to facilitate the cooperation of 3 different research groups, from UNICAMP, USP and University of Copenhagen, in the quest of developing new antimicrobials, nanoformulated (with different drug-delivery carriers) and encapsulated in mesoporous silica/clays, to generate novel pharmaceutical formulations of increased antimicrobial activity against resistant pathoge…
The pilot freeze dryer is essential to the development of lyophilized parenteral formulations that are reproducible, traceable, scalable, without contaminants and stable. Currently there is no pilot freeze dryer available for drug development in Unicamp. The main focus of our research group for years is the parenteral drug formulation, aimed not only at academic research but also the prod…
The NanoSight NS300 Nanoparticle Tracking Analyzer and the Zeta sizer Nano ZS90 Dynamic Light Scatter are equipments based in complementary techniques, both being essential in the characterization of micro and nanoparticule systems such as the lipid-based drug-delivery systems for local anesthetics. The parenteral administration of those requires controlled sizes (< 500nm), low polydispe…
(Only some records are available in English at this moment)
Of the malignant tumors registered in Brazil, skin cancer is the most frequent and corresponds to about 30% of the cases. Melanoma is a type of skin cancer that, despite its low incidence (3% of malignant neoplasms), is the most aggressive form of skin cancer given its high metastatic potential (mainly brain), high mortality (80%) and resistance to therapy with chemotherapeutic agents. Th…
Breast cancer is the most common solid neoplasm in the world and the most diagnosed among women since the 1990s, affecting several age groups, and being the second most common cause of death, due to cancer, among women. Doxorubicin (DOX) is an antineoplastic antibiotic from the anthracycline group, isolated from fungal cultures of Streptomyces peucetius. DOX is used to treat breast cancer…
Local Anesthetics (LA) are drugs widely used in medical and dental clinics capable of reversibly blocking the painful stimulus without loss of consciousness. However, in some cases AL may not have the desired effects, such as in inflamed tissues. In dental anesthesia, anesthetic failure or a lower degree of analgesia may occur in places with pulpitis or periodontitis processes installed. …
The use of Nanostructured Lipid Carriers (NLC) in drug delivery has attracted attention in last years. Developed in the end of the 90's, the core of NLC is composed of a mixture of solid lipid and liquid lipids, which allows for high drug upload and increased stability of the nanoparticles. However, the immiscibility between NLC excipients and between excipients and incorporated drugs can…
The encapsulation of Local Anesthetics (LA) in ionic gradient liposomes (IGL) has been shown to increase the time of analgesia and decrease the side effects, by maintaining the drug in the site of action for a longer time. Intradermal administration of IGL prepared with (NH4)2SO4 in a human volunteer achieved up to 19, 38, and 48 h of successful anesthesia with 0.5, 1, and 2% bupivacaine …
Pain control in burn injuries and their treatment remains a difficult challenge. Opioid therapy, although often used, has several limitations. An alternative to meet such demand is the application of local anesthetics, which are potential drugs for the treatment of such injuries. Bupivacaine is the local anesthetic most used worldwide in surgeries and postoperative periods, with a time of…
(Only some records are available in English at this moment)
In the pharmaceutical field, several variables and processes can affect the properties and characteristics of new formulations. Therefore, the use of powerful algorithms during data analysis allows adoption of proper mathematical models as a strategy to reduce the complexity of the subject and increase our knowledge of the overall system. During this BEPE, ComDim algorithm will be used to…
Local anesthetics (AL) are drugs widely used in medical and dental clinics being capable of reversibly blocking the painful stimulus without loss of consciousness. However, in some cases AL may not have the desired effects, such as in inflamed tissues. To circumvent this situation, ALs can be encapsulated in nanostructured lipid carriers (NLC) composed of synthetic or natural excipients i…
Local anesthetics (LAs) are often used in medical practice when it is necessary to numb parts of the body. Although desirable, local anesthetics cannot guarantee the selective blockage of nociceptive fibers causing adverse reaction (motor and autonomic blockage). Recently, it was reported that the application of local anesthetic followed by capsaicin leads to a selective increase in senso…
Lipid rafts are functional microdomains enriched in cholesterol and sphingolipids which are present in biological membranes. Operationally rafts are defined as detergent-resistant membranes (DRMs) since they resist to extraction by certain cold detergents. In the last decade, rafts have been described as potentially important organizers of survival signaling in prostate cancer cells, with…
| 1 / 1 | Ongoing research grants |
| 17 / 12 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 44 / 20 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 3 / 3 | Completed scholarships abroad |
| 69 / 40 | All research grants and scholarships |
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