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Universidade de São Paulo (USP). Instituto de Química (IQ) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Alexander Henning Ulrich in research grants and scholarships supported by FAPESP.
| Articles published in Pesquisa FAPESP Magazine about the researcher: |
| Déficit inicial |
| Neuron maker |
| El hacedor de neuronas |
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| News published in Agência FAPESP Newsletter about the researcher |
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| TITULO |
| Articles published in other media outlets ( ): |
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| VEICULO: TITULO (DATA) |
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The current global sociodemographic scenario is characterized by an increase in life expectancy and an increasingly aging population. Chile and Brazil have an aging population in increasing leading to an increase in the prevalence of age-related diseases Alzheimer's (AD) and Parkinson's disease (PD) are the leading cause of disability and these disorders are expected to significantly incr…
Flow cytometry is widely used not only in the clinical environment of hospitals, but it has become a technique that is highly used and cited in indexed international journals in the most diverse fields of scientific research. In the Pubmed database (pubmed.ncbi.nlm.nih.gov) there are a total of 1,761 manuscripts published on flow cytometry in the state of São Paulo (viewed on 01/12/2023),…
Glioblastoma multiforme (GBM) is the most common and aggressive primary malignant neoplasm of the CNS. Patients, even with an aggressive standard of treatment, have an average survival of 15 months and a 5-year survival of less than 5%. There are currently more than 150 cancer chemotherapy drugs approved worldwide, but only three are approved for the treatment of GBM patients. It is there…
The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Pr…
Maqui (Aristotelia chilensis) is a big business for the export of its fruit, of great antioxidant properties, which has conquered the agri-food industry. Maqui fruit and leaves have shown an important range of biological actions, including antioxidants, anti-inflammatory and analgesic, leading to obtain products as complementary therapeutic agents in the treatment of various chronic and d…
(Only some records are available in English at this moment)
Neurodevelopmental disorders are diseases characterized by disturbances in healthy neural development, such as autism spectrum disorders, attention deficit hyperactivity disorder, schizophrenia, among others. In vivo models of maternal immune activation (MIA) exhibit behavioral features found in humans with autism spectrum disorder (ASD), such as decreased social interest and repetitive b…
Bipolar disorder (BD) represents a psychiatric condition with a high degree of disability and few diagnostic and treatment tools due to the poorly elucidated biomolecular mechanism and the overlap of symptoms with other disorders, making it extremely important to better understand the pathophysiology of BD. The neurobiological factors involved in this disorder include mechanisms of neuroi…
(Only some records are available in English at this moment)
Several pieces of evidence point to inflammation as a relevant phenomenon in Alzheimer's Disease (AD), promoting alterations in the beta-amyloid (A²) degradation process and in the induction of neuronal death. Studies indicate that microglial activation is involved in both processes. In AD, the presence of A² promotes the activation of microglia with the participation of the P2X7R recepto…
Alzheimer's disease (AD) is a progressive and disabling neurodegenerative condition, with an increasing prevalence, projected to affect approximately 100 million people by 2050. Initially, it manifests with memory impairment and language difficulties, progressing to total loss of communication and physical skills. Neuropathological features include neuritic plaques, neurofibrillary tangle…
Parkinson's Disease is a neurological disorder characterized by motor and cognitive impairments, such as tremors, postural instability, muscular rigidity, and bradykinesia. Its repercussions can significantly impact behavior and homeostasis, and its pathophysiology is not yet fully understood. As a neurodegenerative disease, it is known that inflammation plays a significant role in the pr…
(Only some records are available in English at this moment)
Schizophrenia is a neuropsychiatric disorder with complex etiology. Itpresents psychotic symptoms, cognitive impairments, and psychosocial challenges. Current therapeutic approaches fail to address all dimensions of the disease, emphasizing the necessity for innovative solutions. This project investigates the expression of CaMKII-¿, a critical enzyme in synaptic plasticity, and its modula…
Human memory is a complex higher-order cognitive process responsible for classifying, encoding, storing, and retrieving information. Protein synthesis in the hippocampus and the interaction dynamic between them are essential for forming long-term memory (LTM). Our previous findings suggest that the interaction dynamics of cell division cycle protein 37 (CDC37) with STX1A, LRRK2, and THAP7…
The basal ganglia are a core that controls movement. Its circuitry is mainly formed by inputs from cortical and thalamic glutamatergic neurons, striatal and pallidal GABAergic neurons, and dopaminergic neurons from substantia nigra. Dopamine receptors on GABAergic neurons control their excitability, plasticity, and neurotransmitter release. Parkinsonian rodents present hypoactivity of dop…
Alzheimer's Disease (AD) and major depression (MD) are highly comorbid conditions which have no effective treatment recently available to prevent their chronification. This situation may be ascribed to the translational gap between animal-based models used in preclinical studies and patients as well as under-explored pathological mechanisms underlying AD and MD. Aiming to address these is…
Socio-cognitive deficits are common features present in several neurodevelopmental and psychiatric disorders, including schizophrenia. However, the brain mechanisms underlying such social dysfunctions are still poorly understood. Recently, the purinergic system has earned attention, and it is known that the role of purinergic signaling in schizophrenia is mostly related to the effects of …
(Only some records are available in English at this moment)
| 3 / 3 | Ongoing grants |
| 11 / 9 | Completed research grants |
| 6 / 6 | Ongoing scholarships in Brazil |
| 69 / 40 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 9 / 9 | Completed scholarships abroad |
| 100 / 69 | All research grants and scholarships |
| Associated processes | |