Henning Ulrich graduated in Biology at the Universitat Kiel (Christian-Albrechts) (1986), master degree in Biochemical Parasitology from the Universitat Kiel (Christian-Albrechts) (1991), Ph.D. in Neuroscience from Universidade de Hamburgo (1995), Habilitation in Biochemistry at the University of São Paulo in 2007; Full Professor of Biochemistry. He has experience in Molecular Biology, Biochemistry and Biophysics, acting on the following subjects: aptamer selectiom, stem cells and neural differentiation, calcium signaling, neurotransmitter receptor pharmacology and kinetics. He is currently President of the Brazilian Purine Club, councilor of the International Society for Advancement of Cytometry (ISAC), Associate Editor of Cytometry A, Academic Editor PLoS-ONE and Associate Editor of Purinergic Signalling, Journal of Cancer Stem Cell Research, Stem Cell Reviews & Reports.. (Source: Lattes Curriculum)
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The biological process of neurogenesis that consists of differentiation of neural stem cells (NSC) into neurons, occurs both in embryonic and adult phases. Therefore, NSC are being proposed as interesting tools for nervous system tissue regeneration and restoration of physiological conditions, as well as models for elucidation of pathophysiological development of neurological diseases. Pr…
Maqui (Aristotelia chilensis) is a big business for the export of its fruit, of great antioxidant properties, which has conquered the agri-food industry. Maqui fruit and leaves have shown an important range of biological actions, including antioxidants, anti-inflammatory and analgesic, leading to obtain products as complementary therapeutic agents in the treatment of various chronic and d…
Stem cells (SC) are unspecialized cells withself renewal capacity and with the ability to originate different cell types | of the body. In recent years, SC nave emerged as a significant therapeutic promise for several diseases. Furthermore, cancer stem cells (CSC ) have been implicated in initiation and growth of tumors, resistance to conventional therapies and, consequently, in recurrenc…
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Human memory is characterized as a higher cognitive process and is responsible for classifying, encoding, storing, and retrieving information. Many of the cellular and molecular processes related to memory are already known. However, the formation mechanism is still not completely elucidated. Protein synthesis and interaction dynamics between them, in the hippocampus, are essential for me…
Postnatal development events determine the establishment of neuronal networks and cognition. Neuronal network formation is based on synaptogenesis and synaptic refinement that occur intensely during the so-called critical period of development. Due to its properties, the period of establishment of the neuronal circuitry is highly susceptible to the occurrence of persistent changes in cogn…
Bipolar disorder (BD) is a mood disorder characterized by alternating episodes of depression and episodes of mania. This disorder is known to affect many aspects of physiology and behavior, including memory and learning. Currently, to study and understand BD and other psychiatric disorders, endophenotypes are used, such as neuronal immaturity in the dentate gyrus. The heterozygous knockou…
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Currently, Alzheimer's Disease (AD) is the most prevalent form of dementia, characterized by memory loss, changes in personality and impaired reasoning. Like other neurodegenerative diseases, AD presents a major brain inflammation process at the beginning of its development. This neuroinflammation is known to be triggered by the hyperactivation of glial cells. The persistence of this proc…
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Alzheimer's Disease (AD) and major depression (MD) are highly comorbid conditions which have no effective treatment recently available to prevent their chronification. This situation may be ascribed to the translational gap between animal-based models used in preclinical studies and patients as well as under-explored pathological mechanisms underlying AD and MD. Aiming to address these is…
Socio-cognitive deficits are common features present in several neurodevelopmental and psychiatric disorders, including schizophrenia. However, the brain mechanisms underlying such social dysfunctions are still poorly understood. Recently, the purinergic system has earned attention, and it is known that the role of purinergic signaling in schizophrenia is mostly related to the effects of …
Neurodegenerative disorders such as Parkinson's and Alzheimer's diseases are characterized by the selective and progressive loss of neurons in the brain. There are no treatments to cure such devastating diseases. Current therapies only focus on treatment the symptoms in an attempt to improve the patient's quality of life. The neural stem cells replacement therapy is believed to be one of …
Amyotrophic lateral sclerosis (ALS) is the main motor neuron disease affecting more than 400,000 people worldwide with mortality rate of 92%. There is no cure for ALS and available treatments can only extend the lifespan of the patients in 3 months. Mesenchymal stem cells (MSC) are immunomodulators that regulate cellular processes by either cell-cell contact or their paracrine effect. MS…
Glioblastoma (GBM) stem-like cells (GSCs) represent a subpopulation of intratumoral undifferentiated cells, which would be able to reinitiate tumorigenesis after treatment and recapitulate the heterogeneity of the original tumor. Similar to physiological neural stem cells, GSCs are postulated to self-renewal and differentiate into progenitors cells, which in turn gradually differentiate i…
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| 1 / 1 | Ongoing research grants |
| 9 / 7 | Completed research grants |
| 8 / 8 | Ongoing scholarships in Brazil |
| 57 / 28 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 6 / 6 | Completed scholarships abroad |
| 83 / 52 | All research grants and scholarships |
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