CV Lattes
ORCID
graduation at Farmácia Bioquímica from Universidade de São Paulo (2000), master's at Ciências Farmacêuticas [Rib. Preto] from Universidade de São Paulo (2002) and doctorate at Chemistry from Universidade de São Paulo (2005). Has experience in Farmácia, focusing on Farmácia, acting on the following subjects: natural products, biological activities, alternanthera maritima, amaranthaceae, srtxrf, x-ray fluorescence, chromatography, HPLC, GC, RMN. (Source: Lattes Curriculum)
- Integrated chemical and biological study in the search for bioactive substances in plants* and development of analytical procedures. *(Amaranthaceae, Gesneriaceae, Myrtaceae e Annonaceae), AP.R
Abstract
In this project is proposed the chemical study and evaluation of biological activities to search for bioactive compounds in plant species (mainly, Amaranthaceae, Gesneriaceae, Myrtaceae and Annonaceae) aiming integrated and continued studies within the chemical area of natural products with emphasis in the search for compounds (volatile and non-volatile) with a potential antimicrobial a...
- Investigation of treatment with 24-epibrassinolide in plant development, profile of volatile constituents and biological activities of essential oils from Cymbopogon citratus, Cymbopogon flexuosus and Mentha pulegium, AP.R
Abstract
Some essential oils have antibacterial and antifungal activities and antiproliferative effect against human cancer cell lines. Antimicrobial agents, including essential oils, are used as drugs and as preservatives in pharmaceutical and food industry. Essential oils have important applications in agriculture and in clinical and preventive dentistry. Brassinosteroids increased the levels ...
- Natural photosensitizers in photodynamic therapy: chemical-pharmacological search in plants and analytical procedures, AP.R
Abstract
The main goal of this project is the chemical-pharmacological search of natural photosensitizers in Brazilian plants (Amaranthaceae-Gomphreneae and Myrtaceae - genus Campomanesia, Eugenia and Myrcia) and development of analytical produres, aimed at photodynamic therapy (PDT) employment. The phytochemical study will be carried using absorption spectra measurement in the visible region an...
(Only some records are available in English at this moment)
- Preventive effect of Ilex paraguariensis preparations (chimarrão, terere and mate tea) against damages caused by chronic ethanol consumption: comparative analysis of preparation technology, chemical profile and evaluation of therapeutic effect and safety, BP.DR
Abstract
Alcoholism is defined by the 10th edition of the International Classification of Diseases (ICD-10) of the World Health Organization (WHO), as a set of behavioral, cognitive and physiological phenomena that develop after repeated use of alcohol. Psychiatric illness. The WHO estimates that there are 140 million people worldwide with alcoholism and in Brazil, the average consumption is sup...
- Chemical and biotechnological study of Sinningia (Gesneriaceae) and evaluation of photoinduzed biological effect for PDT, BP.DD
Abstract
The use of natural products dates back to ancient times and many are known to treat various diseases and is an inspiration for medicinal chemistry and a valuable source for the production of drugs due to the enormous diversity of chemical substance classes and distinct functions. Worldwide, and particularly in Brazil, holder of a fantastic biodiversity, only a small fraction of these or...
- Comparative study of the use of reactor, ultrasound and maceration in the preparation of standardized extracts of Alternanthera paronychioides and evaluation of antioxidant activity, BP.IC
Abstract
The objective of this project is to perform the comparative study of the use of reactor, ultrasound and maceration as extraction methods for the preparation of standardized extracts in total flavonoids of Alternanthera paronychioides (Amaranthaceae), a Brazilian plant with potential antioxidant activity and antidiabetics. Therefore, it will be used as extractive liquids, distilled water...
- Sargassum vulgare of the São Paulo state northern coast: analysis of heavy metals and the associated microbiota, BP.IC
Abstract
In this study will be used an instrumental analytical technique of X-ray fluorescence (XRF) and will be conducted to develop analytical procedures for the detection and quantification of trace elements in seaweeds of the genus Sargassum in port locations of São Sebastião, Caraguatatuba and Ubatuba. There will be a comparison of these specimens with other standard Sargassum (NIES Certifi...
- Microbiological investigation, growing conditions and metabolic potential in the search for bioactive natural products in endophytic fungus AC-1 isolated from Annona Cacans, BP.MS
Abstract
This project of investigation aims to investigate the conditions for growth and production of secondary metabolites in biotechnological study with endophytic fungus strain AC1 isolated from the leaves of Annona cacans (Annonaceae), with a view to obtaining bioactive substances from the chemical / biological study of the crude extract of these endophytes. To do so, shall isolating and id...
(Only some records are available in English at this moment)
- Mass spectrometry imaging technique to study drug distribution in different tumor tissue, BE.EP.DD
Abstract
Most anticancer drugs have limited penetration into tumor tissues, which contributes to their low efficacy, making the anticancer therapy difficult. Pharmacokinetic studies have been conducted using HPLC-MS techniques, measuring plasma drug concentration, assuming it is in equilibrium with tissue concentration, however drug penetration into the tumor depends on its microenvironment, tha...
- Application of biophotonics in the study of the interactions of alkaloids isomoschatoline and palmatine with targeted vectors and correlation with their biological effects, BE.EP.DR
Abstract
Research of natural products has been a simple and successful strategy that has contributed to new drug discovery with technological application (Harvey, 2000). In industrialized countries, 25% of prescribed drugs contain at least one active constituent derived from the plant kingdom. However, in the therapeutics, the number of available drugs for the treatment of infectious diseases an...
- Application of biophotonics in the analyses of the photosensitizers isoquinoline alkaloids berberine e isomoschatoline interaction with LDL in cell models, BE.EP.DR
Abstract
The use of nontoxic dyes or photosensitizers (PS) in combination with non-harmful visible light in medicine, called Photodynamic Therapy, is known to more than 100 years, however, only now it has been widely used to treat infectious diseases and cancers. Previous analyses of absorption and fluorescence spectroscopy of isoquinoline alkaloids berberine and isomoschatolina have revealed th...
| 4 / 4 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 25 / 17 | Completed scholarships in Brazil |
| 3 / 3 | Completed scholarships abroad |
| 34 / 26 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 6 |
| Citations | 29 |
| Cit./Article | 4.8 |
| Data from Web of Science | |
SALVADOR‚ MJ; MOREIRA‚ S.; DIAS‚ DA; ZUCCHI‚ O.. Determination of trace elements in Alternanthera brasiliana and Pfaffia glabrata by SRTXRF: application in environmental pollution control. Instrumentation Science & Technology, v. 32, n. 3, p. 321-333, 2004.
BRIGHENTI, FERNANDA LOURENCAO; SALVADOR, MARCOS JOSE; LACERDA GONTIJO, ALINE VIDAL; BOTAZZO DELBEM, ALBERTO CARLOS; BOTAZZO DELBEM, ADINA CLEIA; SOARES, CRISTINA PACHECO; CARVALHO DE OLIVEIRA, MARIA ALCIONEIA; GIRONDI, CAMILA MIORELLI; KOGA-ITO, CRISTIANE YUMI. Plant extracts: initial screening, identification of bioactive compounds and effect against Candida albicans biofilms. FUTURE MICROBIOLOGY, v. 12, n. 1, p. 15-27, JAN 2017. Web of Science Citations: 5. (08/04114-2, 14/09666-4)
TEODORO, GUILHERME RODRIGUES; LACERDA GONTIJO, ALINE VIDAL; BORGES, ALINE CHIODI; TANAKA, MARCIA HIROMI; GOUVEA LIMA, GABRIELA DE MORAIS; SALVADOR, MARCOS JOSE; KOGA-ITO, CRISTIANE YUMI. Gallicacid/hydroxypropyl-beta-cyclodextrin complex: Improving solubility for application on in vitro/in vivo Candida albicans biofilms. PLoS One, v. 12, n. 7, JUL 11 2017. Web of Science Citations: 3. (14/02354-7, 14/09666-4, 15/03470-3, 14/13469-0, 13/00037-1, 12/16805-5)
SALVADOR‚ M.J.; LOPES‚ G.N.; NASCIMENTO FILHO‚ V.F.; ZUCCHI‚ O.L.A.D.. Quality control of commercial tea by x-ray fluorescence. X-RAY SPECTROMETRY, v. 31, n. 2, p. 141-144, 2002.
SALVADOR‚ MJ; ZUCCHI‚ O.; CANDIDO‚ RC; ITO‚ IY; DIAS‚ DA. In vitro antimicrobial activity of crude extracts and isolated constituents of Alternanthera maritima. Pharmaceutical Biology, v. 42, n. 2, p. 138-148, 2004.
TEODORO, GUILHERME R.; GONTIJO, ALINE V. L.; SALVADOR, MARCOS J.; TANAKA, MARCIA H.; BRIGHENTI, FERNANDA L.; DELBEM, ALBERTO C. B.; DELBEM, ADINA C. B.; KOGA-ITO, CRISTIANE Y.. Effects of Acetone Fraction From Buchenavia tomentosa Aqueous Extract and Gallic Acid on Candida albicans Biofilms and Virulence Factors. FRONTIERS IN MICROBIOLOGY, v. 9, APR 5 2018. Web of Science Citations: 5. (12/16805-5, 14/09666-4, 13/00037-1)
SILVA, ADSON S.; AMORIM, MAGALI S.; FONSECA, MARIANA M.; SALVADOR, MARCOS J.; DE SA, EDUARDO L.; STEFANELLO, MARIA ELIDA A.. A New Cytotoxic Naphthoquinone and Other Chemical Constituents of Sinningia reitzii. Journal of the Brazilian Chemical Society, v. 30, n. 10, SI, p. 2060-2065, OCT 2019. Web of Science Citations: 0. (15/03726-8, 17/03598-5)
ANDREAZZA, NATHALIA LUIZA; VEVERT-BIZET, CHRISTINE; BOURG-HECKLY, GENEVIEVE; SUREAU, FRANCK; SALVADOR, MARCOS JOSE; BONNEAU, STEPHANIE. Berberine as a photosensitizing agent for antitumoral photodynamic therapy: Insights into its association to low density lipoproteins. International Journal of Pharmaceutics, v. 510, n. 1, p. 240-249, AUG 20 2016. Web of Science Citations: 16. (11/23031-3)
GONTIJO, ALINE V. L.; SAMPAIO, ALINE DA G.; KOGA-ITO, CRISTIANE Y.; SALVADOR, MARCOS J.. Biopharmaceutical and antifungal properties of ellagic acid-cyclodextrin using an in vitro model of invasive candidiasis. FUTURE MICROBIOLOGY, v. 14, n. 11, p. 957-967, JUL 2019. Web of Science Citations: 0. (14/09666-4, 16/21207-0, 16/07196-6)
(References retrieved automatically from State of São Paulo Research Institutions)
PASCOAL, Aislan Cristina Rheder Fagundes. Prospecção de antioxidantes e de substâncias com atividade antiproliferativa em campomanesia adamantium (Myrtaceae). 2012. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP).
LOURENÇO, Caroline Caramano de. Fitoquímica e avaliação do efeito biológico fotoinduzido de extratos e substâncias isoladas de Annonaceae (planta in natura e obtida por cultura de células). 2016. Tese (Doutorado) – Universidade Estadual de Campinas, Instituto de Biologia.
PAVANI, Matheus. Persistência de fragrância em cabelo : influência das propriedades físico-químicas e da encapsulação de óleo essencial. 2014. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP).
PASCOAL, Aislan Cristina Rheder Fagundes. Campomanesia adamantium e Campomanesia guaviroba : fitoquímica e estudo in vitro e in vivo visando a determinação da atividade biológica e toxicidade. 2015. Tese (Doutorado) – Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP).
FELTRAN, Gabriel Primini. Estudo comparativo da complexação de monoterpenos em ciclodextrina : preparação, caracterização química, desenvolvimento tecnológico e avaliação biológica. 2014. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP).
ANTUNES, João Victor Martins. Efeito do 24-epibrassinolídeo na modulação do perfil de constituintes voláteis e nas atividades biológicas e antioxidante dos óleos essenciais das folhas de Mentha pulegium e de Mentha piperita (Lamiaceae). 2015. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP).
TASCO, Alvaro José Hernández. Investigação microbiológica, condições de crescimento e potencial metabólico para a busca de produtos naturais bioativos no fungo endofítico Cladosporium sp. (AC-1) isolado de Annona cacans (Annonaceae). 2016. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP).
ANDREAZZA, Nathalia Luiza. Prospecção de metabólitos secundários e fitoderivados bioativos em Guatteria blepharophylla (Annonaceae) e Indigofera truxillensis (Fabaceae) para aplicação em terapia fotodinâmica e desenvolvimento de procedimentos analíticos. 2014. Tese (Doutorado) – Instituto de Biologia. Universidade Estadual de Campinas.
LOURENÇO, Caroline Caramano de. Bioprospecção de fotossensiblizadores naturais e substâncias bioativas em Eugenia chlorophylla e desenvolvimento de procedimentos analíticos. 2012. Dissertação (Mestrado) - Instituto de Biologia. Universidade Estadual de Campinas (UNICAMP).