Abstract
The human HTRA1 enzyme (High-Temperature Requirement protein A1, Q92743 Uniprot) is a 51 kDa non-glycosylated serine protease located primarily in the extracellular environment. This enzyme is involved in the remodeling of the extracellular matrix (ECM) by degrading its components, such as decorim, fibronectin, aggrecam and collagen. The mode of action of HTRA1 is related to its serine pr…