bachelor's at Farmácia from Centro Universitário Franciscano (2005), master's at Pharmacology from Universidade Estadual de Campinas (2010) and doctorate at Pharmacology from Universidade Estadual de Campinas (2013). Has experience in Pharmacology, focusing on General Pharmacology, acting on the following subjects: cav1.2, detrusor overactivity, obesity, l-name and diabetes mellitus. (Source: Lattes Curriculum)
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Obesity is a worldwide epidemy with increasing prevalence and is a major independent risk factor for type 2 diabetes and many other diseases. In the early stages of obesity-induced type 2 diabetes, the cells of the body become insulin resistant as the downstream signaling pathways following insulin receptor stimulation become less responsive. Therefore, pancreatic beta-cells start to secr…
The COVID-19 outbreak has reached pandemic levels and has been causing an unprecedent number of deaths worldwide. The high disease transmissibility and the absence of vaccines or therapies, in combination with the high demand for ventilators in order to keep patients alive, yielded a tragic scenario in which the consequence is the collapse of the health systems in addition to several deat…
(Only some records are available in English at this moment)
Cold exposure unlocks several adaptive metabolic events that allows for an optimal adaptive thermogenesis as way to defend body core temperature. Brown fat is the major organ orchestrating this adaption, and it utilizes circulating glucose and triglycerides as fuels to metabolize and sustains the heat production. Several oxidized lipids are active in this process, supporting brown fat in …
Brown adipocytes are known for their thermogenic potential, initiated by the activation of adrenergic receptors coupled to a G protein. The activation of these receptors in cells with high metabolic activity leads to an increase of intracellular cyclic AMP (cAMP), which, in excess, is pulled out of the cell by MRPs (Multidrug Resistance Proteins) channels. Extracellular cAMP/AMP can be co…
Obesity is a worldwide epidemic with increasing prevalence and is a major independent risk factor for Type 2 Diabetes and many other diseases. In the early stages of Obesity induced Type 2 Diabetes, the cells of the body become insulin resistant as the downstream signaling pathways following insulin receptor stimulation become less responsive. Therefore, pancreatic beta-cells start to sec…
(Only some records are available in English at this moment)
Omega-3 lipids are able of affect hepatic function, specially by reducing de novo lipogenesis and hepatic glucose production. Our preliminary data suggest that the desaturasde enzyme stearoyl desaturase-1 (Scd1) is a potential target for these anti-lipogenic lipids. The increase in Scd1 activity leads to the hepatic production of mounsaturated fatty acids (MUFAs), which in turns is requir…
Obesity is related to the onset of several comorbidities, including type-2 diabetes, non-alcoholic fatty liver disease (NAFLD), hypertension, and dyslipidemia. NAFLD is one of the most prevalent complications derived from obesity, and its incidence is growing worldwide.NAFLD is characterized by an elevated accumulation of fat in form of triacylglycerol (TAG) in the liver, while in more se…
The novel coronavirus disease pandemic, caused by the SARS-CoV-2 virus, is causing an unprecedented number of hospitalizations and deaths worldwide, which seems to be far from over. The high transmissibility and the absence of vaccines and effective therapies against this infection, combined with the need for intubation of patients on ventilators in ICU beds, composes a tragic scenario wh…
(Only some records are available in English at this moment)
Brown adipose tissue (BAT), have an inherent capacity to convert excess food energy into thermal energy instead ATP. BAT is important for both basal and inducible energy expenditure in the form of thermogenesis mediated by the expression of the tissue specific uncoupling protein 1 (UCP1). Clusters of UCP1-expressing adipocytes with thermogenic capac¬ity also develop in white adipose tissu…
| 4 / 4 | Ongoing research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 8 / 8 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 17 / 17 | All research grants and scholarships |
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CV Lattes
ORCID