CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
bachelor's at Farmácia from Centro Universitário Franciscano (2005), master's at Pharmacology from Universidade Estadual de Campinas (2010) and doctorate at Pharmacology from Universidade Estadual de Campinas (2013). Has experience in Pharmacology, focusing on General Pharmacology, acting on the following subjects: cav1.2, detrusor overactivity, obesity, l-name and diabetes mellitus. (Source: Lattes Curriculum)
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This application aims to consolidate a collaboration between two research groups with overlapping interests and synergistic experimental competences. Our groups are located at the University of São Paulo, Brazil, and at the University of Copenhagen, Denmark. Here, we propose a plan of joint activities including visits and exchange of faculty staff and PhD students. These exchanges will al…
The prevalence of metabolic diseases such as obesity and type-2 diabetes mellitus (T2DM) are increasing worldwide while the pharmacological treatments are limited. Previous results from our group showed that a thromboxane receptor (TP) antagonist reduced fasting blood glucose, circulating insulin levels and glucose tolerance similarly to metformin. Moreover, we found it decreased LDL and …
Obesity is a worldwide epidemy with increasing prevalence and is a major independent risk factor for type 2 diabetes and many other diseases. In the early stages of obesity-induced type 2 diabetes, the cells of the body become insulin resistant as the downstream signaling pathways following insulin receptor stimulation become less responsive. Therefore, pancreatic beta-cells start to secr…
The COVID-19 outbreak has reached pandemic levels and has been causing an unprecedent number of deaths worldwide. The high disease transmissibility and the absence of vaccines or therapies, in combination with the high demand for ventilators in order to keep patients alive, yielded a tragic scenario in which the consequence is the collapse of the health systems in addition to several deat…
(Only some records are available in English at this moment)
The recruitment and activation of brown adipose tissue (BAT) is one of the main means of controlling and maintaining body weight and glycemic homeostasis. A key protein responsible for BAT thermogenesis, uncoupling protein 1 (UCP1), is regulated by norepinephrine released by sympathetic terminals during cold exposure. The presence of norepinephrine and its interaction with beta-adrenergic…
Adaptive thermogenesis is the production of heat stimulated by cold or diet, this process is mediated by both the brown adipose tissue (BAT) and beige adipose tissue. Thermogenic adipose tissues are abundant in immune cells, which modulate the differentiation and activation of these tissues. B cells are central components in the assembly of the humoral immune response, and additionally, …
Obesity is a pandemic with increasing prevalence and is a major independent risk factor for type 2 diabetes development and many other diseases. Insulin resistance can be observed in the early stages of obesity induced type 2 diabetes. Increased level of circulating insulin is usually noticed before hyperglycemia. Indeed, it can be observed two weeks after a high fat diet challenge. Hyper…
(Only some records are available in English at this moment)
Cold exposure unlocks several adaptive metabolic events that allows for an optimal adaptive thermogenesis as way to defend body core temperature. Brown fat is the major organ orchestrating this adaption, and it utilizes circulating glucose and triglycerides as fuels to metabolize and sustains the heat production. Several oxidized lipids are active in this process, supporting brown fat in …
Brown adipocytes are known for their thermogenic potential, initiated by the activation of adrenergic receptors coupled to a G protein. The activation of these receptors in cells with high metabolic activity leads to an increase of intracellular cyclic AMP (cAMP), which, in excess, is pulled out of the cell by MRPs (Multidrug Resistance Proteins) channels. Extracellular cAMP/AMP can be co…
Owing to its capacity of increasing energy expenditure and promoting glucose and triglycerides clearance from circulation, brown adipose tissue (BAT) has become a major therapeutic target to combat diabetes, obesity and related conditions. Besides, BAT also promote beneficial metabolic effects as an endocrine organ, thereby secreting factors that regulate glucose and lipid homeostasis in …
(Only some records are available in English at this moment)
Obesity is a pandemic with increasing prevalence and is a major independent risk factor for type 2 diabetes development and many other diseases. Insulin resistance can be observed in the early stages of obesity induced type 2 diabetes. Increased level of circulating insulin is usually noticed before hyperglycemia. Indeed, it can be observed two weeks after a high fat diet challenge. Hyper…
Brown adipose tissue (BAT), have an inherent capacity to convert excess food energy into thermal energy instead ATP. BAT is important for both basal and inducible energy expenditure in the form of thermogenesis mediated by the expression of the tissue specific uncoupling protein 1 (UCP1). Clusters of UCP1-expressing adipocytes with thermogenic capac¬ity also develop in white adipose tissu…
| 2 / 2 | Ongoing grants |
| 4 / 4 | Completed research grants |
| 7 / 7 | Ongoing scholarships in Brazil |
| 11 / 11 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 26 / 26 | All research grants and scholarships |
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