bachelor's at Farmácia from Centro Universitário Franciscano (2005), master's at Pharmacology from Universidade Estadual de Campinas (2010) and doctorate at Pharmacology from Universidade Estadual de Campinas (2013). Has experience in Pharmacology, focusing on General Pharmacology, acting on the following subjects: cav1.2, detrusor overactivity, obesity, l-name and diabetes mellitus. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
Obesity is a worldwide epidemy with increasing prevalence and is a major independent risk factor for type 2 diabetes and many other diseases. In the early stages of obesity-induced type 2 diabetes, the cells of the body become insulin resistant as the downstream signaling pathways following insulin receptor stimulation become less responsive. Therefore, pancreatic beta-cells start to secr…
The COVID-19 outbreak has reached pandemic levels and has been causing an unprecedent number of deaths worldwide. The high disease transmissibility and the absence of vaccines or therapies, in combination with the high demand for ventilators in order to keep patients alive, yielded a tragic scenario in which the consequence is the collapse of the health systems in addition to several deat…
Due to the remarkable capacity of Brown Adipose Tissue (BAT) to combust glucose and fatty-acids and the presence of BAT in adult humans, this tissue has been considered as an attractive target for the treatment or prevention of Type-2 Diabetes (T2DM)/Obesity. Nonetheless, BAT activation results in improved insulin sensitivity and glucose utilization in other tissues, such as liver or musc…
Brown adipocytes are known for their thermogenic potential, initiated by the activation of adrenergic receptors coupled to a G protein. The activation of these receptors in cells with high metabolic activity leads to an increase of intracellular cyclic AMP (cAMP), which, in excess, is pulled out of the cell by MRPs (Multidrug Resistance Proteins) channels. Extracellular cAMP/AMP can be co…
Obesity is a worldwide epidemic with increasing prevalence and is a major independent risk factor for Type 2 Diabetes and many other diseases. In the early stages of Obesity induced Type 2 Diabetes, the cells of the body become insulin resistant as the downstream signaling pathways following insulin receptor stimulation become less responsive. Therefore, pancreatic beta-cells start to sec…
Cold exposure unlocks several adaptive metabolic events that allows for an optimal adaptive thermogenesis as way to defend body core temperature. Brown fat is the major organ orchestrating this adaption, and it utilizes circulating glucose and triglycerides as fuels to metabolize and sustains the heat production. Several oxidized lipids are active in this process, supporting brown fat in …
Owing to its capacity of increasing energy expenditure and promoting glucose and triglycerides clearance from circulation, brown adipose tissue (BAT) has become a major therapeutic target to combat diabetes, obesity and related conditions. Besides, BAT also promote beneficial metabolic effects as an endocrine organ, thereby secreting factors that regulate glucose and lipid homeostasis in …
Omega-3 lipids are able of affect hepatic function, specially by reducing de novo lipogenesis and hepatic glucose production. Our preliminary data suggest that the desaturasde enzyme stearoyl desaturase-1 (Scd1) is a potential target for these anti-lipogenic lipids. The increase in Scd1 activity leads to the hepatic production of mounsaturated fatty acids (MUFAs), which in turns is requir…
(Only some records are available in English at this moment)
Brown adipose tissue (BAT), have an inherent capacity to convert excess food energy into thermal energy instead ATP. BAT is important for both basal and inducible energy expenditure in the form of thermogenesis mediated by the expression of the tissue specific uncoupling protein 1 (UCP1). Clusters of UCP1-expressing adipocytes with thermogenic capac¬ity also develop in white adipose tissu…
| 2 / 2 | Ongoing research grants |
| 2 / 2 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 10 / 10 | Completed scholarships in Brazil |
| 1 / 1 | Completed scholarships abroad |
| 17 / 17 | All research grants and scholarships |
| Associated processes | |
CV Lattes
ORCID