- Research Grants
bachelor's at Farmácia from Universidade São Francisco (2009) and master's at Clinical Medicine from Universidade Estadual de Campinas (2012). Has experience in Pharmacology, focusing on Pharmacology, acting on the following subjects: gastric secretion, p38, signaling pathways, peptidoglycan and lipopolysaccharide . (Source: Lattes Curriculum)
During inflammatory responses, neutrophils and other leukocytes adhere to the endothelium, leaving the blood vessels and actively moving towards the inflammatory sites. At present, specific inflammatory mechanisms that operate in the neutrophil adhesive properties have not been completely described. Using a model of neutrophil activation by TNF-±, a potent inflammatory cytokine that ind...
During the inflammatory response, neutrophils and other leukocytes adhere to the endothelium, before their extrasvasation from the blood vessel in the direction of the site of inflammation. The migration of the neutrophils depends on a series of adhesive and chemotactic events that result from receptor- mediated cell activation, involving interactions between selectins, integrins, and o...
Evidence suggests that haem may represent a novel DAMP. Haem generated by intra and extra-vascular haemolysis activates innate immune cells and non-hematopoietic cells, promoting pro-inflammatory activities, such as leukocyte activation, migration and infiltration, adhesion molecule activation, cytokine release and inflammasome formation. Our data suggest that haem is a potent driver of...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
SILVEIRA, Angélica Aparecida Antoniellis. Investigação das propriedades pró-inflamatórias do TNF-"alfa" e do heme em leucócitos "in vitro" e "in vivo". 2017. Tese (Doutorado) – Universidade Estadual de Campinas, Faculdade de Ciências Médicas. (12/22048-2)