CV Lattes
ResearcherID
ORCID
Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Bacharelado em Física from Pontifícia Universidade Católica do Rio de Janeiro (1988), master's at Byophysics from Universidade Federal do Rio de Janeiro (1990) and ph.d. at Ph.d. in Biomedical Sciences from Mount Sinai School of Medicine, City University of New York (1994). Has experience in Genetics, focusing on Human and Medical Genetics, acting on the following subjects: célula tronco embrionária, clonagem, marfan sindrome, ética and modelos animais. (Source: Lattes Curriculum)
| News published in Agência FAPESP Newsletter about the researcher |
| TITULO |
| Articles published in other media outlets (0 total): |
| More itemsLess items |
| VEICULO: TITULO (DATA) |
| VEICULO: TITULO (DATA) |
We propose a program of basic and clinical research to isolate, culture, and characterize embryonic ,somatic, and neoplastic stem cells in order to understand their biology and apply this knowledge to therapy, comprising four research lines: (1) pluripotent stem cells (SC) (embryonic SC and induced pluripotent SC); (2) somatic SC (hematopoietic SC, mesenchymal SC, endothelial SC, and canc…
The corona virus disease-19 (COVID-19) pandemic is a global emergency that already affects approximately 200 countries and territories worldwide and continues to spread rapidly, making it the greatest challenge facing humanity in a hundred years. Contrary to what happened in other recent pandemics, such as Influenza A H1N1, there are still no drugs that are proven effective against the di…
Marfan syndrome (MFS) is a connective tissue disease caused by variants in the FBN1 gene. Nevertheless, other genes influence the manifestations of the disease, characterized by high clinical variability even within families. We mapped modifier loci for cardiovascular and skeletal manifestations in the mgloxPneo mouse model for MFS and the synthenic loci in the human genome. Corroborat…
(Only some records are available in English at this moment)
Marfan Syndrome (MFS) is an autosomal dominant genetic condition, with complete penetrance, inter and intra-family clinical variability. It has an incidence of 1 in approximately 5,000 individuals, around 25% of these cases are sporadic. The systems most affected by the syndrome are ocular, cardiovascular and skeletal. MFS is caused by pathogenic variants in the FBN1 gene, which encodes t…
X Chromosome Inactivation (XCI) is an important cellular process that occurs naturally in females of several animal species, including placental mammals, preventing X-linked gene transcripts from being present twice as much in females than in males. It consists in the silencing of one of the two X chromosomes in female cells, acting as an epigenetic mechanism of genic dosage compensation.…
Hypertension is an important risk factor for several cardiovascular diseases, such as stroke, acute myocardial infarction, and chronic kidney disease. It is a complex, multifactorial disease, using cellular/molecular mechanisms that are not well understood. Increasing evidence in recent decades may cause an association between Reactive Oxygen Species (ROS, English, Reactive Oxygen Species…
(Only some records are available in English at this moment)
Hypertension is an important risk factor for various cardiovascular diseases, such as stroke, acute myocardial infarction and chronic kidney disease. It is a complex, multifactorial disease whose cellular mechanisms are still poorly understood. Recently, several studies have focused on the role of oxidative stress in the development of hypertension. Increasing evidence over the last decad…
Chromosomal Translocations between X and autosomes are a common cause of male infertility in many species, including those from the Drosophila genus. Such a phenomenon is associated in the literature with a regulatory mechanism called Meiotic Sex Chromosome Inactivation (MSCI). Our most recent research has demonstrated that the loss of RNA polymerase II activity during the last phases of …
In placental mammals, the inactivation of extra copies of the X chromosome is essential for the viability of female embryos. Despite being well described in the mouse, the X chromosome inactivation (XCI) process in preimplantation human embryos is yet to be elucidated. Due to the ethical and technical barriers associated with the use of human embryos in research, the development of a stem…
The X chromosome inactivation is the dosage compensation mechanism present in most mammals, where one of the two X chromosomes in females is silenced in order to achieve the same expression level of the only X present in males. This process takes place early in the development and most of what is currently known about it originates from studies with mice.The embryonic nature of this mecha…
Marfan syndrome (MFS) is an autosomal dominant disease of the connective tissue, which affects about 1 in 5,000 individuals, and is caused by mutations in FBN1 gene, which encodes the extracellular matrix protein fibrillin-1. The main clinical manifestations involve the vascular and skeletal systems. Despite complete penetrance, MFS has a great clinical variability, even among individuals…
(Only some records are available in English at this moment)
| 1 / 1 | Ongoing research grants |
| 18 / 15 | Completed research grants |
| 56 / 39 | Completed scholarships in Brazil |
| 2 / 2 | Ongoing scholarships abroad |
| 5 / 5 | Completed scholarships abroad |
| 83 / 63 | All research grants and scholarships |
| Associated processes | |