CV Lattes
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Universidade de São Paulo (USP). Instituto de Biociências (IB) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Holds a Bachelor's degree in Physics from the Pontifical Catholic University of Rio de Janeiro (1988), a Master's degree in Biological Sciences (Biophysics) from the Federal University of Rio de Janeiro (1990), and a Ph.D. in Biomedical Sciences from the Mount Sinai Graduate School, City University of New York (1994). Currently, she is a Full Professor and Head of the National Laboratory of Embryonic Stem Cells (LaNCE) in the Department of Genetics and Evolutionary Biology at the University of São Paulo, and a member of the CEPID-FAPESP Center for Cell Therapy. She leads the DNA Brazil Project. She is the founder of the startup gen-t. She has experience in the field of Genetics, with an emphasis on Human and Medical Genetics, focusing mainly on the following topics: Marfan syndrome, pluripotent stem cells, and X chromosome inactivation. (Source: Lattes Curriculum)
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The present proposal establishes the continuity and expansion of the activities of the National Institute of Science and Technology in Stem Cells and Cell Therapy, one of the National Institutes of Science and Technology created by CNPq/FAPESP in 2008. In that opportunity, we proposed the development of an extensive program of basic and clinical research to understand, isolate, culture an…
We propose a program of basic and clinical research to isolate, culture, and characterize embryonic ,somatic, and neoplastic stem cells in order to understand their biology and apply this knowledge to therapy, comprising four research lines: (1) pluripotent stem cells (SC) (embryonic SC and induced pluripotent SC); (2) somatic SC (hematopoietic SC, mesenchymal SC, endothelial SC, and canc…
The corona virus disease-19 (COVID-19) pandemic is a global emergency that already affects approximately 200 countries and territories worldwide and continues to spread rapidly, making it the greatest challenge facing humanity in a hundred years. Contrary to what happened in other recent pandemics, such as Influenza A H1N1, there are still no drugs that are proven effective against the di…
Marfan syndrome (MFS) is a connective tissue disease caused by variants in the FBN1 gene. Nevertheless, other genes influence the manifestations of the disease, characterized by high clinical variability even within families. We mapped modifier loci for cardiovascular and skeletal manifestations in the mgloxPneo mouse model for MFS and the synthenic loci in the human genome. Corroborat…
(Only some records are available in English at this moment)
In placental mammals, the X chromosome extra copies inactivation is essential for the viability of female embryos. Despite being well described in mice [1] [2], the process of X chromosome inactivation (XCI) in pre-implantation human embryos still needs to be elucidated [3] [4]. Due to the ethical and technical barriers associated with the use of human embryos in research, the development…
Hypertension is an important risk factor for several cardiovascular diseases, such as stroke, acute myocardial infarction, and chronic kidney disease. It is a complex, multifactorial disease, using cellular/molecular mechanisms that are not well understood. Increasing evidence in recent decades may cause an association between Reactive Oxygen Species (ROS, English, Reactive Oxygen Species…
Marfan Syndrome (MFS) is an autosomal dominant genetic condition, with complete penetrance, inter and intra-family clinical variability. It has an incidence of 1 in approximately 5,000 individuals, around 25% of these cases are sporadic. The systems most affected by the syndrome are ocular, cardiovascular and skeletal. MFS is caused by pathogenic variants in the FBN1 gene, which encodes t…
X Chromosome Inactivation (XCI) is an important cellular process that occurs naturally in females of several animal species, including placental mammals, preventing X-linked gene transcripts from being present twice as much in females than in males. It consists in the silencing of one of the two X chromosomes in female cells, acting as an epigenetic mechanism of genic dosage compensation.…
Marfan Syndrome (MFS) is an autosomal dominant connective tissue disease that primarily affects skeletal, ocular and cardiovascular systems, been Aortic Aneurysm responsible for most morbidity and mortality. MFS is caused by mutations in the fibrillin-1 gene (FBN1), one of the main structural components of the extracellular matrix and responsible for regulating TGF-² activity. MFS has imp…
(Only some records are available in English at this moment)
Hypertension is an important risk factor for various cardiovascular diseases, such as stroke, acute myocardial infarction and chronic kidney disease. It is a complex, multifactorial disease whose cellular mechanisms are still poorly understood. Recently, several studies have focused on the role of oxidative stress in the development of hypertension. Increasing evidence over the last decad…
Chromosomal Translocations between X and autosomes are a common cause of male infertility in many species, including those from the Drosophila genus. Such a phenomenon is associated in the literature with a regulatory mechanism called Meiotic Sex Chromosome Inactivation (MSCI). Our most recent research has demonstrated that the loss of RNA polymerase II activity during the last phases of …
In placental mammals, the inactivation of extra copies of the X chromosome is essential for the viability of female embryos. Despite being well described in the mouse, the X chromosome inactivation (XCI) process in preimplantation human embryos is yet to be elucidated. Due to the ethical and technical barriers associated with the use of human embryos in research, the development of a stem…
(Only some records are available in English at this moment)
| 2 / 2 | Ongoing research grants |
| 18 / 15 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 54 / 37 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 83 / 63 | All research grants and scholarships |
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