Abstract
Major Depressive Disorder (MDD) is a psychopathology with a high rate of non-responders to the drugs that exist on the market today. Despite that, these drugs may take weeks to start producing their effects. Ayahuasca and ketamine have shown rapid (hours/days) and persistent (weeks) therapeutic effects on MDD. The main active ingredient of ayahuasca is dimethyltryptamine (DMT), a psychede…