bachelor's at Biochemistry and Pharmacy from Universidade Estadual de Londrina (1987) and doctorate at Biochemistry from Universidade Federal de São Paulo (1997). Has experience in Biochemistry, focusing on Molecular Biology, acting on the following subjects: endooligopeptidase, endopeptidase, bradykinin-potentianting peptides(BPPs) and oligopeptidases. (Source: Lattes Curriculum)
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Mental disorders (MDs) are a group of potentially serious and highly prevalent diseases affecting the Central Nervous System (CNS). Studies that seek biochemical/molecular and/or cellular alterations could help in the diagnosis accuracy, as well as for the better understanding of the neurobiology involved in the MDs, thus allowing the possible identification of potential new targets for t…
Toxins from animal venom are a material of great scientific interest, mainly due to their possible use for therapeutic purposes, which includes their use as drugs and/or as structural model for the development of drugs with therapeutic potential for the treatment of human diseases, in addition to their possible application as tools for biotechnological purposes. Crotamine, which is one of…
Venom toxins are of great scientific interest, mainly due to their possible use for therapeutic purposes, i.e., as pharmaceuticals and/or as structural models for the development of drugs that may be employed for the treatment of human and/or for biotechnological applications. Crotamine, which is one of the most abundant toxins of the rattlesnake venom, is capable of penetrating cells, as…
The National Institute of Translational Medicine (NITM) was created in 2008 with the purpose of establishing a national network of research centers with outstanding experience in the investigation of biomarkers and new therapeutic targets and molecules in neuropsychiatric disorders, acting in the strategic area of Health and Medicines defined by the Federal Government. In the base of all …
(Only some records are available in English at this moment)
Oligopeptidases play a fundamental role in the maturation and degradation of bioactive peptides, including hormones and neuropeptides. These enzymes act only on oligopeptides, generally of 8 to 13 amino acids, but they do not cleave larger proteins and do not present primary specificity like classical enzymes/proteases. The activity of oligopeptidases has been widely studied in mental dis…
Mental disorders (MDs) are a group of potentially serious and highly prevalent diseases that affect the Central Nervous System (CNS). Studies that seek biochemical/molecular and/or cellular alterations could help in the accuracy of the diagnosis, and also in a better understanding of the neurobiology involved in TMs, thus enabling the possible identification of potential new targets for t…
The study on the activity of the oligopeptidases Ndel1 (Nuclear distribution element-like 1) and angiotensin I converting enzyme (ACE) is motivated by the fact that these enzymes are neuropeptidases that act in the cleavage of neuropeptides such as neurotensin, which has already been demonstrated to be fundamental for response to antipsychotics and was also considered to be an endogenous …
Angiotensin I converting enzyme (ACE) is a dipeptidyl carboxypeptidase with a key function in the renin angiotensin system (RAS), whose function in the central nervous system (CNS) has only recently attracted the attention of researchers. Interestingly, in addition to being primarily responsible for the conversion of angiotensin I into the hypertensive and pro-inflammatory agent angiotens…
(Only some records are available in English at this moment)
Over the past few years, Hayashi's lab has identified a couple of potential biomarkers to support the diagnosis of mental disorders (MDs), such as schizophrenia (SCZ) and bipolar disorder (BD), while also working on the nuclear distribution element-like 1 (Ndel1) oligopeptidase activity as a potential biomarker for diagnosis and/or treatment response in SCZ. The importance of Ndel1 for ne…
Schizophrenia (SCZ) is a severe chronic mental disease. The current body of evidence suggests that it is a multifactorial disease with genetic and environmental factors, leading to an altered neurodevelopment. Ndel1 (nuclear-distribution element-like 1) is an oligopeptidade that binds to Disrupted-in-Schizophrenia 1 (DISC1) gene product, which has been largely studied as a SCZ vulnerabili…
| 1 / 1 | Ongoing grants |
| 17 / 11 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 15 / 11 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 37 / 27 | All research grants and scholarships |
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CV Lattes
ORCID