CV Lattes
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Secretaria da Saúde (São Paulo - Estado). Coordenadoria de Serviços de Saúde (CSS). Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Medicina from Universidade de São Paulo (1988) and doctorate at Biochemistry from Universidade de São Paulo (1993). He is currently professor of oncology at Universidade de São Paulo. Has experience in Biochemistry, focusing on Glicids, acting on the following subjects: melanoma, galectina-3, microambiente, progressão tumoral and adesao celular. (Source: Lattes Curriculum)
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The Plan aims to implement the strategies defined for establishing the infrastructure required for the advancement of research and innovation within the FMUSP-HC Academic System. It follows the guidelines set out by the "Strategic Foresight" developed by CGEE, the "Future-Seeking" conference by FMUSP, revised in 2021, the "Strategic Planning for Research Management" event held in 2012, th…
The Project aims to support the development of the infrastructure required for research and innovation in the University of São Paulo School of Medicine and Clinics Hospital academic health system (FMUSP-HC). The investments are made according to the strategic plans recently revised and in combination to other infrastructure projects approved by Finep. In the current stage, investments ar…
The Project aims to support the development of the infrastructure required for research and innovation in the University of São Paulo School of Medicine and Clinics Hospital academic health system (FMUSP-HC). The investments are made according to the strategic plans recently revised and in combination to other infrastructure projects approved by Finep. In the current stage, investments we…
(Only some records are available in English at this moment)
The vision of Instituto do Cancer do Estado de Sao Paulo is to constitute an Excellence Center for Total Cancer Care and Research. To reach this goal, it is critically necessary to invest in research and innovation. Our research activities are organized in order to favor the continued search for solutions to the problems experience by the cancer patient daily. (AU)
The vision of Instituto do Câncer do Estado de São Paulo is to constitute an Excellence Center for Total Cancer Care and Research. To reach this goal, it is critically necessary to invest in research and innovation. Our research activities are organized in order to favor the continued search for solutions to the problems experience by the cancer patient daily. (AU)
One of the aims of the Instituto do Câncer do Estado de São Paulo (ICESP) is to constitute an Excellence Center for Research in Oncology, which should be internationally recognized. Investment in research activities is therefore necessary. Research activities are coordinated by two administrative offices, clinical research facility and the center for translational research in oncology. Bo…
(Only some records are available in English at this moment)
Lung cancer is the neoplasia responsible for the highest number of deaths in Brazil and worldwide. Several therapeutic approaches for non-small cell lung cancer (NSCLC), its most common type, are based on chemotherapy with combinations of cisplatin, a drug with cytotoxic potential that acts by causing DNA damage. However, the efficacy of cisplatin is limited due to the development of tumo…
Modifications of intracellular signaling pathways in which mitochondria take part are considered an important pathophysiological component when it comes to understanding the carcinogenic process. Changes in the mitochondrial genetic content play an important role in this context, since mitochondrial DNA (mtDNA) is closely related to cell metabolism and overall cell functioning, by encodin…
Modifications of intracellular signaling pathways in which mitochondria take part are considered an important pathophysiological component when it comes to understanding the carcinogenic process. Changes in the mitochondrial genetic content play an important role in this context, since mitochondrial DNA (mtDNA) is closely related to cell metabolism and overall cell functioning, by encodin…
The tumor microenvironment is composed of several barriers and obstacles that decrease the chemo-radiotherapeutic effectiveness of cancer treatment. One of these obstacles would be the aberrant and deficient vascular network, which limits tumor perfusion, preventing the total delivery of drugs and creating areas of tumor hypoxia. Another would be the presence of tumor-associated macrophag…
(Only some records are available in English at this moment)
Colorectal and pancreatic cancer are among the five leading causes of cancer death in all ages, in the United States, including ovarian cancer in the case of female patients. In common, these tumors have a large amount of extracellular matrix and interstitial fibrosis. These features, associated with aberrant vascularization and poor lymphatic drainage, increase tumor interstitial fluid p…
Metastatic melanoma has been considered a clinical challenge due to its notorious chemoresistance. The understanding of molecular and cellular events that contributes to melanoma chemoresistance is important to improve current therapies and prevent tumor recurrence. Previous in vivo studies from our group showed that PAFR activation favors melanoma growth by protecting to cisplatin-induce…
The presence of high macrophage infiltration within solid tumors correlates with chemoresistance, metastasis, poor prognosis and shorter survival of patients. Strategies that can identify macrophages within the tumor microenvironment or reeducate these cells towards a proinflammatory phenotype can improve the therapies for cancer management. Macrophages are among the most abundant cells i…
(Only some records are available in English at this moment)
| 6 / 6 | Ongoing grants |
| 15 / 12 | Completed research grants |
| 1 / 1 | Ongoing scholarships in Brazil |
| 45 / 33 | Completed scholarships in Brazil |
| 5 / 4 | Completed scholarships abroad |
| 72 / 56 | All research grants and scholarships |
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