CV Lattes
GoogleMyCitations
ResearcherID
ORCID
Secretaria da Saúde (São Paulo - Estado). Coordenadoria de Serviços de Saúde (CSS). Instituto do Câncer do Estado de São Paulo Octavio Frias de Oliveira (ICESP) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduation at Medicina from Universidade de São Paulo (1988) and doctorate at Biochemistry from Universidade de São Paulo (1993). He is currently professor of oncology at Universidade de São Paulo. Has experience in Biochemistry, focusing on Glicids, acting on the following subjects: melanoma, galectina-3, microambiente, progressão tumoral and adesao celular. (Source: Lattes Curriculum)
The vision of Instituto do Cancer do Estado de Sao Paulo is to constitute an Excellence Center for Total Cancer Care and Research. To reach this goal, it is critically necessary to invest in research and innovation. Our research activities are organized in order to favor the continued search for solutions to the problems experience by the cancer patient daily. (AU)
Despite of the uninterrupted development of new medications for the treatment of cancer, the survival rate continues low especially in those patients in the advanced stage of the disease. Recent observations show that new therapeutics increase the susceptibility for cardiovascular diseases, which turns out to be the treatment of cancer even more complex. Cardiac dysfunction due to cardiot…
The vision of Instituto do Câncer do Estado de São Paulo is to constitute an Excellence Center for Total Cancer Care and Research. To reach this goal, it is critically necessary to invest in research and innovation. Our research activities are organized in order to favor the continued search for solutions to the problems experience by the cancer patient daily. (AU)
One of the aims of the Instituto do Câncer do Estado de São Paulo (ICESP) is to constitute an Excellence Center for Research in Oncology, which should be internationally recognized. Investment in research activities is therefore necessary. Research activities are coordinated by two administrative offices, clinical research facility and the center for translational research in oncology. Bo…
Melanoma is responsible for most deaths among all skin cancers and conventionalchemotherapy fails because of the development of chemoresistance. We usedproteomic analysis to identify cellular responses that lead to the chemoresistanceof human melanoma cell lines to cisplatin. A systems approach to the proteomicdata indicated the participation of specific cellular processes such as oxidati…
(Only some records are available in English at this moment)
Modifications of intracellular signaling pathways in which mitochondria take part are considered an important pathophysiological component when it comes to understanding the carcinogenic process. Changes in the mitochondrial genetic content play an important role in this context, since mitochondrial DNA (mtDNA) is closely related to cell metabolism and overall cell functioning, by encodin…
The tumor microenvironment is composed of several barriers and obstacles that decrease the chemo-radiotherapeutic effectiveness of cancer treatment. One of these obstacles would be the aberrant and deficient vascular network, which limits tumor perfusion, preventing the total delivery of drugs and creating areas of tumor hypoxia. Another would be the presence of tumor-associated macrophag…
Liquid biopsies arise as new diagnostic strategies in Cancer, aiming at the analysis of cell-free (cf) analytes in a less-invasive way than solid biopsies. As of today, a great controversy in the literature exists regarding the choice of the better liquid-biopsy target (cfDNA, cfRNA, cf-miRNA or extracellular-vesicles). Here we will focus on extracellular microvesicles (EMV) because they …
(Only some records are available in English at this moment)
Melanoma is considered the most aggressive form of skin cancer. About 60% of the patients harbor a mutation in the BRAF gene, resulting in constitutive activation of the mitogen-activated protein kinase (MAPK) pathway. Combined targeted therapy with BRAF and MEK inhibitors is associated with significant improvement in progression-free survival and objective responses of patients with adva…
Macrophages are a major component of the tumor microenvironment and its presence is generally associated with a worse tumor prognosis, enhancing tumor growth, drug resistance and local immunosupression. Pro-tumoral macrophages generally display an anti-inflammatory profile. Prohibitin 1 (PHB) is a protein with varied functions, with the most well known activities being related to cell cyc…
One of the biggest challenges faced in cancer treatment is the process of tumor repopulation.In this process, cells that are refractory to therapy, are able to proliferate and reconstitute the tumor. Despite its clinical frequency and its contribution to treatment failure, the molecular and cellular events involved in this phenomenon are still poorly understood. The comprehension of these…
(Only some records are available in English at this moment)
Metastatic melanoma has been considered a clinical challenge due to its notorious chemoresistance. The understanding of molecular and cellular events that contributes to melanoma chemoresistance is important to improve current therapies and prevent tumor recurrence. Previous in vivo studies from our group showed that PAFR activation favors melanoma growth by protecting to cisplatin-induce…
The presence of high macrophage infiltration within solid tumors correlates with chemoresistance, metastasis, poor prognosis and shorter survival of patients. Strategies that can identify macrophages within the tumor microenvironment or reeducate these cells towards a proinflammatory phenotype can improve the therapies for cancer management. Macrophages are among the most abundant cells i…
Cutaneous melanoma is one epithelial tumor originates in melanocytes. This tumor represents 4% of malignant neoplasms of skin and it is considered an important public health problem because of its high progression to metastasis and treatment resistance. Previous studies of our group revealed the accumulation of prohibitin (PHB) in cell lines of human melanoma after treatment with cisplati…
| 2 / 2 | Ongoing research grants |
| 13 / 10 | Completed research grants |
| 4 / 4 | Ongoing scholarships in Brazil |
| 40 / 28 | Completed scholarships in Brazil |
| 4 / 3 | Completed scholarships abroad |
| 63 / 47 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 11 |
| Citations | 144 |
| Cit./Article | 13.1 |
| Data from Web of Science | |
KE, WEINA; HONG, ENPING; SAITO, RENATA F.; RANGEL, MARIA CRISTINA; WANG, JIAN; VIARD, MATHIAS; RICHARDSON, MELINA; KHISAMUTDINOV, EMIL F.; PANIGAJ, MARTIN; DOKHOLYAN, V, NIKOLAY; et al. RNA-DNA fibers and polygons with controlled immunorecognition activate RNAi, FRET and transcriptional regulation of NF-B in human cells. Nucleic Acids Research, v. 47, n. 3, p. 1350-1361, FEB 20 2019. Web of Science Citations: 10. (15/22814-5, 17/50029-6)
DE AGUIAR, RODRIGO BARBOSA; PARISE, CAROLINA BELLINI; TEIXEIRA SOUZA, CAROLINA ROSAL; BRAGGION, CAMILA; QUINTILIO, WAGNER; MORO, ANA MARIA; NAVARRO MARQUES, FABIO LUIZ; BUCHPIGUEL, CARLOS ALBERTO; CHAMMAS, ROGER; DE MORAES, JANE ZVEITER. Blocking FGF2 with a new specific monoclonal antibody impairs angiogenesis and experimental metastatic melanoma, suggesting a potential role in adjuvant settings. Cancer Letters, v. 371, n. 2, p. 151-160, 2016. Web of Science Citations: 9. (09/18631-1, 13/06120-8, 98/14247-6)
LONGO MACHADO, CAMILA MARIA; SOUSA ANDRADE, LUCIANA NOGUEIRA; TEIXEIRA, VERONICA RODRIGUES; COSTA, FABRICIO FALCONI; MELO, CAMILA MORAIS; DOS SANTOS, SOFIA NASCIMENTO; NONOGAKI, SUELY; LIU, FU-TONG; BERNARDES, EMERSON SOARES; CAMARGO, ANAMARIA ARANHA; et al. Galectin-3 disruption impaired tumoral angiogenesis by reducing VEGF secretion from TGF beta 1-induced macrophages. CANCER MEDICINE, v. 3, n. 2, p. 201-214, APR 2014. Web of Science Citations: 21. (08/11513-0, 98/14247-6)
IKEMORI, RAFAEL YAMASHITA; LONGO MACHADO, CAMILA MARIA; FURUZAWA, KARINA MIE; NONOGAKI, SUELY; OSINAGA, EDUARDO; UMEZAWA, KAZUO; DE CARVALHO, MARCELO ALEX; VERINAUD, LIANA; CHAMMAS, ROGER. Galectin-3 Up-Regulation in Hypoxic and Nutrient Deprived Microenvironments Promotes Cell Survival. PLoS One, v. 9, n. 11, NOV 4 2014. Web of Science Citations: 21. (09/10857-0, 98/14247-6)
NOVAK‚ E.M.; METZGER‚ M.; CHAMMAS‚ R.; DA COSTA‚ M.; DANTAS‚ K.; MANABE‚ C.; PIRES‚ J.; DE OLIVEIRA‚ AC; BYDLOWSKI‚ SP. Downregulation of TNF-α and VEGF expression by Sp1 decoy oligodeoxynucleotides in mouse melanoma tumor. Gene Therapy, v. 10, n. 23, p. 1992-1997, 2003. (99/00322-9, 98/14247-6)
CARNACHO, XIMENA; MACHADO, CAMILA LONGO; GARCIA, MARIA FERNANDA; GAMBINI, JUAN PABLO; BANCHERO, AGUSTINA; FERNANDEZ, MARCELO; ODDONE, NATALIA; ZANATTA, DANIELA BERTOLINI; ROSAL, CAROLINA; BUCHPIGUEL, CARLOS ALBERTO; et al. Technetium-99m-or Cy7-Labeled Rituximab as an Imaging Agent for Non-Hodgkin Lymphoma. ONCOLOGY, v. 92, n. 4, p. 229-242, 2017. Web of Science Citations: 3. (13/06120-8)
CORREA, MARIANGELA; MACHADO JUNIOR, JOEL; CARNEIRO, CÉLIA R. W.; PESQUERO, JOÃO BOSCO; BADER, MICHAEL; CHAMMAS, ROGER; TRAVASSOS, LUIZ RODOLPHO RAJA GABAGLIA. Transient inflammatory response induced by apoptotic cells is an important mediator of melanoma cell engraftment and growth. International Journal of Cancer, v. 114, n. 3, p. 356-363, Apr. 2005. (98/05505-1)
ONUCHIC, ANA CLAUDIA; MACHADO, CAMILA M. L.; SAITO, RENATA F.; RIOS, FRANCISCO J.; JANCAR, SONIA; CHAMMAS, ROGER. Expression of PAFR as Part of a Prosurvival Response to Chemotherapy: A Novel Target for Combination Therapy in Melanoma. Mediators of Inflammation, 2012. Web of Science Citations: 26. (08/00247-8, 98/14247-6)
SAITO, RENATA DE FREITAS; TORTELLI, JR., THARCISIO CITRANGULO; JACOMASSI, MAYARA D'AURIA; OTAKE, ANDREIA HANADA; CHAMMAS, ROGER. Emerging targets for combination therapy in melanomas. FEBS Letters, v. 589, n. 22, SI, p. 3438-3448, NOV 14 2015. Web of Science Citations: 16. (13/06120-8)
FERREIRA CARDOSO, ANA CAROLINA; DE SOUSA ANDRADE, LUCIANA NOGUEIRA; BUSTOS, SILVINA ODETE; CHAMMAS, ROGER. Galectin-3 Determines Tumor Cell Adaptive Strategies in Stressed Tumor Microenvironments. FRONTIERS IN ONCOLOGY, v. 6, MAY 23 2016. Web of Science Citations: 25. (13/06120-8)
VASCONCELOS, RENATA OTTES; SERINI, SIMONA; DE SOUZA VOTTO, ANA PAULA; TRINDADE, GILMA SANTOS; FANALI, CATERINA; SGAMBATO, ALESSANDRO; CALVIELLO, GABRIELLA. Combination of omega-3 fatty acids and cisplatin as a potential alternative strategy for personalized therapy of metastatic melanoma: an in-vitro study. Melanoma Research, v. 29, n. 3, p. 270-280, JUN 2019. Web of Science Citations: 1. (17/02549-0)
KOVACS, LUCIANA; CABRAL, PABLO; CHAMMAS, ROGER. Mannose receptor 1 expression does not determine the uptake of high-density mannose dendrimers by activated macrophages populations. PLoS One, v. 15, n. 10, OCT 13 2020. Web of Science Citations: 0. (14/20746-0)
OTAKE, ANDREIA HANADA; MATTAR, ANA LUCIA; FREITAS, HELANO CARIOCA; LONGO MACHADO, CAMILA MARIA; NONOGAKI, SUELY; FUJIHARA, CLARICE KAZUE; ZATZ, ROBERTO; CHAMMAS, ROGER. Inhibition of angiotensin II receptor 1 limits tumor-associated angiogenesis and attenuates growth of murine melanoma. Cancer Chemotherapy and Pharmacology, v. 66, n. 1, p. 79-87, MAY 2010. Web of Science Citations: 37. (98/14247-6)
SAITO, RENATA DE FREITAS; TORTELLI, JR., THARCISIO CITRANGULO; JACOMASSI, MAYARA D'AURIA; OTAKE, ANDREIA HANADA; CHAMMAS, ROGER. Emerging targets for combination therapy in melanomas. FEBS Letters, v. 589, n. 22, SI, p. 3438-3448, NOV 14 2015. Web of Science Citations: 16. (13/06120-8)
CORREA, MARIANGELA; MACHADO JUNIOR, JOEL; CARNEIRO, CÉLIA R. W.; PESQUERO, JOÃO BOSCO; BADER, MICHAEL; CHAMMAS, ROGER; TRAVASSOS, LUIZ RODOLPHO RAJA GABAGLIA. Transient inflammatory response induced by apoptotic cells is an important mediator of melanoma cell engraftment and growth. International Journal of Cancer, v. 114, n. 3, p. 356-363, Apr. 2005. (98/05505-1)
(References retrieved automatically from State of São Paulo Research Institutions)
MELO, Fabiana Henriques Machado de. Exploração funcional do processo de glicosilação aberrante em tumores: mecanismos envolvidos na atividade pró-migratória de galectina-3. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (02/09411-9)
TEIXEIRA, Veronica Rodrigues. Mecanismos associados à perda de expressão do gene de galectina-3 em um modelo de progressão de melanoma murino. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (04/14267-0)
OTAKE, Andréia Hanada. "Papel de dissialogangliosídios na proliferação e morte celular induzida de melanócitos e melanomas in vitro". Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (04/01695-3)
ANDRADE, Luciana Nogueira de Sousa. Evidência da dualidade funcional de galectina-3 no crescimento de melanoma murino. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (04/00895-9)
JUNIOR, Tharcisio Citrangulo Tortelli. Avaliação do papel de proibitina no desenvolvimento de resistência à cisplatina em linhagens de melanoma humano. Dissertação (Mestrado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (06/01937-2)
SAITO, Renata de Freitas. Indução de estresse de retículo endoplasmático como estratégia de quimiossensibilização de melanoma. Tese (Doutorado) - Faculdade de Medicina. Universidade de São Paulo (USP). São Paulo. (10/08284-0)
MOLÉCULA HÍBRIDA PARA DIAGNÓSTICO E /OU PROGNÓSTICO DE DOENÇAS CRÔNICO-DEGENERATIVAS, INFECCIOSAS E DO DESENVOLVIMENTO PI0501095-0 - Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Universidade de São Paulo (USP). Roger Chammas; Fabiana Henriques Machado de Melo; Diego Alberto Butera Wadsworth; Ana Maria Moura da Silva - February 2005, 24