CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. Instituto de Ciência e Tecnologia (ICT) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Odontologia from Universidade Estadual Paulista Júlio de Mesquita Filho (1998), master's at Biopatologia Bucal from Universidade Estadual Paulista Júlio de Mesquita Filho (2001) and doctorate at Biopatologia Bucal from Universidade Estadual Paulista Júlio de Mesquita Filho (2003). He is currently full professor at Universidade Estadual Paulista Júlio de Mesquita Filho. Has experience in Odontology, acting on the following subjects: terapia fotodinâmica, candida albicans, candida, candidose and fitoterapia. (Source: Lattes Curriculum)
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At the ICT/UNESP-SJC animal facility, research activities are focused on the medical and dental fields, encompassing various subareas such as pathology, microbiology, immunology, surgery, endodontics, dental prosthetics, periodontics, among others. These research initiatives involve faculty members, researchers, and students from ICT/UNESP and several national and international partner in…
The present work aims to evaluate the antifungal and immunomodulatory effects of gold nanoparticles and iron nanoparticles (Np) associated with natural polyphenols (curcumin, gallic acid or resveratrol) against Candida albicans, using in vitro and in vivo study models. For this, the project will be distributed in eight stages: 1) Evaluation of the antifungal effects of Np associated with …
Candida albicans is the main fungal species associated with the development of oral candidiasis. Currently, therapeutic options for these infections are limited by the adverse effects of antifungal drugs and by the emergence of drug resistant strains. Thus, the development of new antifungal agents is needed for the prevention and treatment of oral Candida infections. Caffeic acid phenethy…
The objective of this study will be isolate and identify strains of Lactobacillus spp. from the oral cavity of individuals caries free and to evaluate their probiotic action in Candida albicans and Streptococcus mutans by in vitro and in vivo studies. Saliva samples will be collected and identified by the API50CHL system and confirmed by Polymerase Chain Reaction (PCR). Thirty strains ide…
(Only some records are available in English at this moment)
The present work aims to evaluate the antifungal and immunomodulatory effects of gold nanoparticles and iron nanoparticles (Np) associated with natural polyphenols (curcumin, gallic acid or resveratrol) against Candida albicans, using in vitro and in vivo study models. For this, the project will be distributed in eight stages: 1) Evaluation of the antifungal effects of Np associated with …
Cutaneous infections caused by Staphylococcus aureus, Acinetobacter baumannii and Candida albicans represent a major challenge in the hospital environment due to the development of strains resistant to antibiotics and antifungals. Antimicrobial photodynamic therapy (aPDT) can be an alternative treatment for these infections, however in vivo study models are restricted to vertebrate animal…
Photodynamic therapy (PDT) is a promising technique that can be used to control Streptococcus mutans. However, it has been necessary to identify photosensitizers with greater effectiveness against S. mutans and to understand how PDT acts on biofilms formed by these microorganisms. In this context, the objective will be to study the Fotoenticine® (FTC) activity in photodynamic therapy agai…
(Only some records are available in English at this moment)
Currently, treatment options for fungal infections are limited due to the low availability of antifungal drugs and the rising of drug resistant strains. Thus, the development of new antifungal compounds and new therapeutic approaches are in great need for the control of these infections. The caffeic acid phenethyl ester (CAPE), caffeic acid (CA) and artepillin C (ARTC), compounds of propo…
In the last years, conventional antifungal screening strategies have failed to yield new classes of effective antimicrobials. New paradigms for discovering novel antimicrobial agents are needed. Ideally, new agents should be effective against persisters cells, the subpopulation of fungal cells that show tolerance to conventional drugs. This is clinically important because persister cells …
In vivo studies are fundamental to the study of microbial interactions of pathogenic microorganisms, and discovery of new antimicrobial agents. An animal model should reproduce the corresponding pathogenesis of infection in humans, including colonization and invasion from a specific route of entry and interaction with the host immune system. The aim of this study is to evaluate in vivo pr…
(Only some records are available in English at this moment)