CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de São José dos Campos. Instituto de Ciência e Tecnologia (ICT) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduate at Odontologia from Universidade Estadual Paulista Júlio de Mesquita Filho (1997), master's at Biopatologia Bucal from Universidade Estadual Paulista Júlio de Mesquita Filho (2001) and ph.d. at Biopatologia Bucal from Universidade Estadual Paulista Júlio de Mesquita Filho (2004). Has experience in Odontology, acting on the following subjects: sinvastatina, regeneração óssea, estatinas, reparação and ovariectomia. (Source: Lattes Curriculum)
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To investigate the role of adrenergic signaling (AS) in the host immune response and Porphyromonas gingivalis virulence, we compared norepinephrine (NE) and isoproterenol (ISO) responses in Galleria mellonella. P. gingivalis infection was evaluated by survival; humoral immune responses (i.e., melanization and cecropin and gloverin mRNA expression); cellular immune responses (i.e., hemocyt…
In recent decades the negative relationship between stress and periodontal disease has been observed. The literature demonstrates that stress aggravates periodontal disease by activation of the central nervous system with release of cortisol, behavior 's alterations, and stimulation of the sympathetic nervous system (SNS) with catecholamines release. The SNS has influence on several facto…
Periodontitis is multifactorial disease caused by biofilm action plus imune and adaptative host response, that results in periodontium destruction. Non surgical scaling and root planing, with or without antibiotics use, are the most used treatments. However, new therapies have been tested, some of them in experimental models, focusing in host response modulation. Probiotics are live micro…
(Only some records are available in English at this moment)
With the global population aging, it is increasingly important to understand how age-related biological processes influence the pathophysiology of chronic inflammatory conditions, including periapical lesions. Although the literature has described the morphological features of radicular cysts and periapical granulomas, it remains unclear whether these characteristics differ between childr…
Among the hyperkeratotic white lesions of the oral mucosa are those of reactive origin, such as frictional keratoses caused by chronic trauma and idiopathic keratoses, as well as potentially malignant disorders, such as leukoplakia and oral lichen planus, and truly malignant cases. In many situations, the diagnosis can be challenging, both clinically and histologically. In this context, a…
Optical microscopy is limited by its low resolution and magnification capabilities, as well as the shallow depth of field, resulting in the formation of two-dimensional images. In this context, it becomes necessary to resort to correlational microscopy to understand the etiopathogenesis of diseases. The aim of this study is to analyze the main fungal and bacterial infections with oral man…
The hyaline ring granuloma is a granulomatous inflammatory reaction characterized by foreign body-type giant cells and eosinophilic ring-shaped structures, often accompanied by fibrosis, macrophages, and other inflammatory cells. It is believed that the cause is the implantation of plant particles in the tissue. Due to the nonspecific clinical characteristics and the relative unfamiliarit…
Cell senescence is characterized by the irreversible arrest of the cell cycle with establishment of the senescence-associated secretory phenotype (SASP) and production of cytokines that, if not efficiently eliminated, are a source of chronic inflammation. Senolytics induce senescent cells to apoptosis, and their use has been encouraging in studies of systemic age-related bone loss. Combin…
Aging is associated to alveolar bone loss (ABL) and to an increase in periodontitis prevalence and severity. Besides oral hygiene, there are no therapeutic strategies to effectively prevent aging-related ABL. Cellular senescence is characterized by irreversible cell cycle arrest and a senescence-associated secretory phenotype, with production of cytokines which, if not efficiently cleared…
(Only some records are available in English at this moment)
In recent decades, an association between stress and periodontal disease has been observed. The literature suggests that stress aggravates periodontal disease by activation of different pathways, one of them being stimulation of the sympathetic nervous system (SNS) with catecholamines release. The SNS has an influence on several factors associated with the pathogenesis of periodontal dise…