CV Lattes
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Universidade Estadual de Campinas (UNICAMP). Centro de Hematologia e Hemoterapia (HEMOCENTRO) (Institutional affiliation from the last research proposal) Birthplace: Brazil
Associate Professor of Hematology of the Department of Clinical Medicine, School of Medical Sciences, UNICAMP. Graduated in Medicine from the University of Campinas (1998), with specialization in hematology and hemotherapy (2001); PhD in Medical Physiopathology from the University of Campinas (2006). Areas of interest as a researcher are are the interactions between hemostasis and inflammation, and the diagnosis and management of disorders of hemostasis and thrombosis, and medical education. Member of the Technical Committee on Hemostasis of the Brazilian Association of Hematology and Hemotherapy, and currently, Vice-Dean of the School of Medical Sciences of University of Campinas. (Source: Lattes Curriculum)
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Hemostasis and innate immunity are closely linked processes that contribute to containing the progression of infectious agents, thus constituting an effector mechanism of host defense, which is conventionally called "immunothrombosis". However, unregulated and excessive activation of this process causes secondary tissue injury and micro and macrovascular thrombosis. Although initially des…
Research in translational medicine is based on using different systems (in vitro, ex vivo, and in vivo, for instance) to answer medical questions and therefore to translate findings between these different systems. To achieve this, there is a need for cutting-edge equipment at the intersection between the bench and hospitals. To propel the quality of the translational medicine research de…
The proposal to create the Center for Thromboembolic Diseases (CDT) fits within FAPESP's call for Science Centers for Development since it deals with an important public health issue, with a great social and economic. This center will contribute to obtaining access to epidemiological and cost-effective data on treatments, helping in public policy. An important tool, the development of an …
Severe forms of COVID-19 are characterized by intense inflammation associated with significant increase in biomarkers of hemostasis activation. According to the concept of immunothrombosis, hemostasis and inflammation are intimately connected elements of the host response to pathogens. Based on this model, when regulated, local activation of hemostasis contributes to pathogen eradication,…
Thromboembolic disorders represent a major culprit for morbidity-mortality in Brazil and the World. The Hemocentro at Unicamp has a scientifically recognized research group, with over 100 highly cited publications in this field. We have revealed the roles of FVIII, VWF and of ADAMTS13 in Deep Venous Thrombosis (DVT) and severe Post-Thrombotic Syndrome (PTS); the association between hyperc…
Acute graft-versus-host disease (aGVHD) is a major cause of premature death in hematopoietic stem cell transplantation (HSCT). From classic studies conducted in the 1980s, the breakdown of intestinal epithelial barrier in the initial phase of HSCT has been recognized as a critical pathophysiological event for aGVHD. This breakdown allows the translocation of antigens from the intestinal l…
(Only some records are available in English at this moment)
Acute promyelocytic leukemia (APL) is part of the group of acute myeloid leukemias and is characterized by having the best long-term prognosis. On the other hand, its initial treatment is characterized by high morbidity and early mortality. The occurrence of a severe hemorrhagic syndrome at the time of diagnosis, in a significant number of patients, results in the most relevant aspect of …
Hypercoagulability is a hallmark of sickle cell disease (SCD), and its pathophysiology is related to the concomitant activation of hemostasis and innate immunity, in a process known as immunothrombosis. Among the mechanisms involved in immunothrombosis, the best known are the generation of neutrophil extracellular networks (NETs) and the expression of tissue factor by monocytes, but over …
Febrile neutropenia (FN) frequently occurs after chemotherapy for hematological malignancies and is a potentially serious complication in this group of patients, as it increases the risk of septic shock. Despite advances in supportive care, gaps remain in our knowledge about the pathophysiology of sepsis complications in the context of FN. Furthermore, the association between neutropenia …
Febrile Neutropenia (NF) is a serious complication of antineoplastic chemotherapy, particularly in hematologic patients. Among the most feared complications of NF are Sepsis and septic shock. Despite advances in supportive therapy, the understanding of Sepsis pathophysiology remains incomplete, limiting the development of target-specific therapies. Studies in animal models and biomarkers …
Sickle Cell Disease (SCD) is the most frequent hereditary hemoglobinopathy in the world, which despite the advances in pathophysiological knowledge and in the treatment of support, continues to have a great negative impact on the quality of life and survival of patients. It has been known for at least 50 years that patients with SCD have elevated levels of free heme in circulation, associ…
(Only some records are available in English at this moment)
Hypercoagulability is a hallmark of sickle cell disease (SCD), and its pathophysiology is related to the concomitant activation of hemostasis and innate immunity, in a process known as immunothrombosis. The mechanisms involved include the generation of neutrophil extracellular traps (NETs), complement activation, and the expression of tissue factor on monocytes and extracellular vesicles …
| 3 / 3 | Ongoing grants |
| 8 / 6 | Completed research grants |
| 2 / 2 | Ongoing scholarships in Brazil |
| 10 / 9 | Completed scholarships in Brazil |
| 1 / 1 | Ongoing scholarships abroad |
| 24 / 21 | All research grants and scholarships |
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