Abstract
The mechanisms by which NADPH oxidase complex is activated are still poorly unkown, although its importance for understanding of the redox cell signaling pathways. Recently we described that loss-of-function of protein disulfide isomerase (PDI), a chaperone superfamily of thioredoxin, decreased Nox1 NADPH oxidase isoform expression as well as reactive oxygen species (ROS) production indu…