Abstract
Dengue is one of the most important viral infections that occur in tropical and subtropical regions of the world, affecting about 50 million people and causing more than 25,000 deaths annually. In Brazil, dengue virus serotype-1 (DENV-1) was reintroduced in 1981 and since then, the 4 serotypes began to circulate in different regions of the country. Despite the steady increase in the numbe…