CV Lattes
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Universidade de São Paulo (USP). Faculdade de Medicina de Ribeirão Preto (FMRP) (Institutional affiliation from the last research proposal) Birthplace: Brazil
graduation at Ciências Biológicas from Universidade de São Paulo (1976), master's at Biochemistry from Universidade de São Paulo (1979) and doctorate at Biochemistry from Universidade de São Paulo (1983). He is currently full professor at Faculdade de Medicina de Ribeirão Preto. Has experience in Immunology, focusing on Celular Imunology, acting on the following subjects: trypanosoma cruzi, citocinas, chemokines, quimiocinas and t. cruzi. (Source: Lattes Curriculum)
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The purpose of the Cell Sorter Aria III CDU 5B/3R/6V is to analyze and separate distinct cell populations from samples containing mixtures of cells, such as peripheral blood, lymphoid tissues, tumors, solid organs, or other tissues. The equipment will be part of the equipment park of the Translational Medicine Research Platform - Fiocruz/Ribeirão Preto School of Medicine - USP, and will b…
The purpose of the FACSymphony A5 SE Flow Cytometer is to analyze (phenotipar) distinct cellular populations of samples containing mixtures of cells, such as peripheral blood, lymphoid tissues, tumours, solid organs or other fabrics. (AU)
Emerging and re-emerging diseases are a major public health problem. In the past years, the world has been threatened by several important emerging or re-emerging infectious diseases, such as Ebola, Avian Influenza A, Yellow Fever (YFV), Dengue (DENV), West Nile Fever (WNV) among others. In Brazil, the emerging infections caused by arboviruses such as DENV and YIF are historical and have …
(Only some records are available in English at this moment)
Current knowledge of T cell immunity to Zika virus is minimal. For a disease of such diverse outcomes, from asymptomatic exposure to Guilain-Barre syndrome or neonatal microcephaly, there is a pressing need to characterize immunity so as to comprehend the difference between protective and pathogenic T cell responses. In West Nile virus (WNV) infection, for example, neuropathgenic complica…
A feature common to the pathogenesis of flavivirus exposure in humans is the diversity of clinical outcomes. In the case of exposure to Zika virus, outcomes can range from asymptomatic exposure to fever, rash, joint pain, conjunctivitis, Guillain Barre syndrome and probably, neonatal microcephaly. Some regions of Brazil (including Sao Paulo where our study will be based) have witnessed a …
Among bacterial infections, tuberculosis is the disease which causes the highest number of deaths. Even being extensively studied considering the relationship of the host with the pathogen Mycobacterium tuberculosis, etiologic agent of this disease, the factors that contribute for the development of active and progressive tuberculosis in immune competent individuals are complex and still …
(Only some records are available in English at this moment)
Leishmaniasis is a parasitic disease considered one of the main global public health problems. They are characterized by presenting a range of cutaneous, mucocutaneous and visceral clinical symptoms that are determined by the species of the parasite, and nutritional, genetic, and immunological aspects of the individual. Visceral Leishmaniasis (VL), which results from infection with Leishm…
In the last 15 years, my lab has dedicated to understand the mechanisms by which Plasmodium infection stimulate the innate immune responses and what is the outcome of these responses in host resistance to infection and pathogenesis of Malaria. The current research program includes three projects around a main theme, which is "Immunological mechanisms of host resistance and disease in Mala…
The physiological balance provided by the regulation of the immune system is described as a critical point for the maintenance of homeostasis between specialized cells and cytokines. Thus, the function of inflammatory cytokines is well defined, among which the IL-12 family is known for its role in T helper lymphocytes. The IL-12 family consists of heterodimers that form five cytokines des…
In the last 15 years, my lab has dedicated to understand the mechanisms by which Plasmodium infection stimulate the innate immune responses and what is the outcome of these responses in host resistance to infection and pathogenesis of . The current research program includes three projects around a maintheme, which is "Immunological mechanisms of host resistance and disease in Malaria". I…
(Only some records are available in English at this moment)
Leishmaniasis is a disease transmitted by sand fly bites into host's skin, therefore the immune response against the parasite is initiated early in the skin, even in visceral cases. Murine models have shown that immune responses against Leishmania are very diverse, and may depend on the parasite species, strains and/or mice background. This is especially true for the roles played by infla…
The fungus Paracoccidioides brasiliensis is sensed by the Toll-like receptors 2, 4 (TLR2, 4) and dectin-1. The fungal recognition by dectin-1 is essential for NF-kB activation and induction of the expression of pro-IL-1B. The expression, maturation and secretion of IL-1B are processes tightly controlled. A major inflammatory pathway involved in the release of this cytokine is the activati…
The parasite Trypanosoma cruzi is agent causative of Chagas disease. This pathogen causes robust innate immune responses in immunocompetent hosts, resulting in the recruitment of mononuclear cells to the heart. The pattern recognition receptors (PRRs), including TLR-2, -4, -7, and -9, as well as the cytosolic receptor Nod1 recognize pattern molecular pathogen associated to T. cruzi and tr…
(Only some records are available in English at this moment)
| 5 / 5 | Ongoing research grants |
| 24 / 11 | Completed research grants |
| 3 / 3 | Ongoing scholarships in Brazil |
| 60 / 33 | Completed scholarships in Brazil |
| 7 / 7 | Completed scholarships abroad |
| 99 / 59 | All research grants and scholarships |
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