José C Toledo Jr. is chemist with a master's (1999) and phD at Chemistry from Universidade de São Paulo (2004). Has experience in Chemistry and Biochemistry focusing on Inorganic Chemistry, acting on the following subjects: nitric oxide, óxido nítrico, nitrosyl complexes, ruthenium complexes and rutênio. (Source: Lattes Curriculum)
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S-nitrosation affects activity, association and localization of proteins of several functional classes and influences several cellular and organismal physiological processes, emerging as a conserved, ubiquitous, nitric oxide dependent post-translation signaling mechanism. Yet, basic chemical principles of biosignaling such as kinetics, selectivity, and specificity of s-nitrosation, and th…
S-nitrosation of cysteine residues is believed to be a universal and common nitric oxide (NO*) dependent post-translational modification that affects the activity, association, and cell compartmentalization of numerous proteins and enzymes and controls or modulates distinct biological processes such as metabolism, gene expression, and cell death. However, there exists certain resistance t…
Head and neck squamous cell carcinoma is the sixth most common cancer with more than 500 thousand patients worldwide each year. The combination of the two well known drugs, Cisplatin and fluorouracil, has been used for treatment of this type of cancer. However, recently, it has been reported that the enzyme system glutathione/glutathione s-transferases (GSH/GSTs) causes neck squamous cell…
Recent studies show that the reaction of deoxyhemoglobin and nitrite yields small but sustained amounts of s-nitrosohemoglobin (bCys93-(NO)HbFe2+), a Hb species where the Hb b chain cysteine 47 residue is found s-nitrosated. It has been hypothesized that s-nitrosohemoglobin somehow releases NO or NO equivalents that promote vasodilation during the hemoglobin R/T allosteric transition upon…
| 3 / 3 | Completed research grants |
| 7 / 3 | Completed scholarships in Brazil |
| 10 / 6 | All research grants and scholarships |
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