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José C Toledo Jr. is chemist with a master's (1999) and phD at Chemistry from Universidade de São Paulo (2004). Has experience in Chemistry and Biochemistry focusing on Inorganic Chemistry, acting on the following subjects: nitric oxide, óxido nítrico, nitrosyl complexes, ruthenium complexes and rutênio. (Source: Lattes Curriculum)
|News published in Agência FAPESP Newsletter about the researcher|
|Novel activity of iron in all human cells is discovered|
S-nitrosation affects activity, association and localization of proteins of several functional classes and influences several cellular and organismal physiological processes, emerging as a conserved, ubiquitous, nitric oxide dependent post-translation signaling mechanism. Yet, basic chemical principles of biosignaling such as kinetics, selectivity, and specificity of s-nitrosation, and ...
S-nitrosation of cystein residues is believed to be a universal and common nitric oxide (NO*) dependent post translational modification that affects the activity, association and cell compartimentalization of numerous proteins and enzymes and controls or modulates distinct biological processes such as metabolism, gene expression and cell death. However, there exists certain resistance t...
Head and neck squamous cell carcinoma is the sixth most common cancer with more than 500 thousand patients worldwide each year. The combination of the two well known drugs, Cisplatin and fluorouracil, has been used for treatment of this type of cancer. However, recently, it has been reported that the enzyme system glutathione/glutathione s-transferases (GSH/GSTs) causes neck squamous ce...
Recent studies show that the reaction of deoxyhemoglobin and nitrite yields small but sustained amounts of s-nitrosohemoglobin (bCys93-(NO)HbFe2+), a Hb species where the Hb b chain cystein 47 residue is found s-nitrosated. It has been hypothesized that s-nitrosohemoglobin somehow releases NO or NO equivalents that promotes vasodilation during the hemoglobin R/T allosteric transition up...
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
|Data from Web of Science|
(References retrieved automatically from State of São Paulo Research Institutions)
JUNIOR, José Carlos Toledo. Aspectos da reatividade de complexos de rutênio contendo óxido nítrico como ligante. 2004. 119f. Tese (Doutorado) – Instituto de Química de São Carlos. Universidade de São Paulo (USP). São Carlos. (99/11252-1)