CV Lattes
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Universidade Estadual Paulista (UNESP). Campus de Araraquara. Faculdade de Ciências Farmacêuticas (FCFAR) (Institutional affiliation for the last research proposal) Birthplace: Brazil
graduate at Farmácia Bioquímica from Universidade Estadual Paulista Júlio de Mesquita Filho (1987), master's at Pharmacy from Universidade de São Paulo (1995) and ph.d. at Toxicology from Universidade de São Paulo (2003). Has experience in Pharmacology, focusing on Toxicology, acting on the following subjects: farmacocinética, toxicologia, carvedilol, idosos and etambutol. (Source: Lattes Curriculum)
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Pharmacotherapy has been extensively applied on a wide variety of diseases, is usually of lower cost and risk and is the most frequently used method in the clinic for the treatment and prevention of acute and chronic diseases. It is imperative that the development of therapeutic alternatives occurs continuously, since new pandemics present themselves in modern times. The life expectancy o…
Poor pharmacokinetic properties and toxicity constitute more than 50% of important causes of costly late-stage failures in drug development to produce alternative therapies for humans. Thus, the pharmacokinetics should be evaluated earlier in the drug development, for the simultaneous improvement of the pharmacokinetics and pharmacological potency that may result in a more promising candi…
Chagas disease is an illness that affects millions of people worldwide, especially in developing countries. It is caused by the parasite Trypanosoma cruzi, which causes serious harm to the host, particularly in cardiac tissue. In Brazil, the only drug available to treat Chagas disease is benznidazole. The drug is administered only as immediate release tablets of 100 mg (Ministry of Health…
(Only some records are available in English at this moment)
The improvement of technologies in analysis and synthesis, structural characterization and the introduction of combinatorial chemistry promoted an acceleration in obtaining new synthetic compounds. Early evaluations of pharmacokinetic properties through in vitro assays provide notions of absorption, allowing preliminary screening by excluding less promising candidates and direct investmen…
Metabolic instability is one of the main pharmacokinetic processes whose inadequate characteristics may impair the development of a drug candidate, since it affects parameters such as clearance, half-life and bioavailability, and is also related to toxicity. In vitro metabolism assay may be performed with cells or cell animal model in which the pharmacokinetic assay is planned, or with ce…
Vitamin D has been used in the treatment and prevention of both osteoporosis and osteomalacia. The deficiency of vitamin D is related to several autoimmune diseases and therapeutic protocols, therefore, long term high doses of vitamin D are used for the treatment of these diseases. The therapeutic use of vitamin D must be controlled in order to avoid its main adverse effects - hypercalcem…
(Only some records are available in English at this moment)
The Laboratory of Preclinical Pharmacokinetics of New Drugs and Medicines is a research group involved in the pharmacokinetics study of new drugs in Brazil. Many new compounds are found with unfavourable pharmacokinetics characteristics despite observable pharmacologic effect. The explanation may be in the metabolites of these drugs, therefore the study of these products will improve the …
Sickle cell disease is the most common and severe monogenic disorder worldwide. It is characterized by episodes of acute disability and progressive organ damage. In order to treat the symptoms of this disease, a phtalimide derivative, LAPDESF-SCD03, was planned to have nitric oxide donor activity and anti-inflammatory activity, which has been shown in published studies. The characterizati…
| 5 / 5 | Completed research grants |
| 20 / 15 | Completed scholarships in Brazil |
| 2 / 2 | Completed scholarships abroad |
| 27 / 22 | All research grants and scholarships |
| Associated processes | |
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
| Publications | 16 |
| Citations | 54 |
| Cit./Article | 3.4 |
| Data from Web of Science | |
DAVANCO, MARCELO GOMES; CAMPOS, MICHEL LEANDRO; NOGUEIRA, MARCO ANTONIO; CAMPOS, SILVIO LOPES; MARQUES, RICARDO VIAN; DOS SANTOS, JEAN LEANDRO; CHIN, CHUNG MAN; DA FONSECA, LUIZ MARCOS; PECCININI, ROSANGELA GONCALVES. In vitro and in vivo evaluation of a primaquine prodrug without red blood cell membrane destabilization property. BIOPHARMACEUTICS & DRUG DISPOSITION, v. 33, n. 8, p. 437-445, NOV 2012. Web of Science Citations: 2.
CANDIDO, CAROLINE DAMICO; CAMPOS, MICHEL LEANDRO; CORREA VIDIGAL ASSUMPCAO, JULIANA URUGUAY; PESTANA, KELLY CHRYSTINA; PADILHA, ELIAS CARVALHO; CARLOS, IRACILDA ZEPPONE; PECCININI, ROSANGELA GONCALVES. Biocompatible Microemulsion Modifies the Tissue Distribution of Doxorubicin. Journal of Pharmaceutical Sciences, v. 103, n. 10, p. 3297-3301, OCT 2014. Web of Science Citations: 2. (11/11239-9)
FRANCHIN, TAISA BUSARANHO; ULIAN SILVA, BRUNA CRISTINA; DEGRANDIS, RONE APARECIDO; CORREA, MICHELLE FIDELIS; SIMOES DE QUEIROZ ARANHA, CECILIA MARIA; FERNANDES, JOAO PAULO S.; CAMPOS, MICHEL LEANDRO; PECCININI, ROSANGELA GONCALVES. Assessment of the Physicochemical Properties and Stability for Pharmacokinetic Prediction of Pyrazinoic Acid Derivatives. CURRENT DRUG METABOLISM, v. 21, n. 9, p. 714-721, 2020. Web of Science Citations: 0. (16/23139-2, 16/25028-3, 16/23229-1)
ALONSO, J. M.; PECCININI, R. G.; CAMPOS, M. L.; NITTA, T. Y.; AKUTAGAWA, T. Y. M.; CRESCENCIO, A. P.; ALVES, A. L. G.; RODRIGUES, C. A.; WATANABE, M. J.; HUSSNI, C. A.. Plasma and peritoneal fluid concentrations of ceftriaxone after intravenous and intraperitoneal administration in horses. VETERINARY JOURNAL, v. 234, p. 72-76, APR 2018. Web of Science Citations: 0. (13/13799-7, 11/11239-9)
PADILHA, ELIAS C.; WANG, JIANYAO; KERNS, ED; LEE, ARTHUR; HUANG, WENWEI; JIANG, JIAN-KANG; MCKEW, JOHN; MUTLIB, ABDUL; PECCININI, ROSANGELA G.; YU, PAUL B.; et al. Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). FRONTIERS IN PHARMACOLOGY, v. 10, APR 24 2019. Web of Science Citations: 1. (16/07381-8)
PADILHA, ELIAS CARVALHO; PIRES, RODRIGO VIEIRA; FERRAZ NOGUEIRA FILHO, MARCO ANTONIO; DE PONTES MACHADO, DIEGO VINICIUS; BALDAN, HELEN MARIANA; DAVANCO, MARCELO GOMES; CAMPOS, MICHEL LEANDRO; BRUNETTI, IGUATEMY LOURENCO; PECCININI, ROSANGELA GONCALVES. Pharmacokinetic and safety evaluation of the use of ciprofloxacin on an isoniazid-rifampicin regimen in rabbits. BIOPHARMACEUTICS & DRUG DISPOSITION, v. 33, n. 9, p. 501-509, DEC 2012. Web of Science Citations: 2.
DOS SANTOS, JEAN LEANDRO; MOREIRA, VANESSA; CAMPOS, MICHEL LEANDRO; CHELUCCI, RAFAEL CONSOLIN; BARBIERI, KARINA PEREIRA; MAGGIO DE CASTRO SOUTO, POLLYANA CRISTINA; MATSUBARA, MARCIO HIDEKI; TEIXEIRA, CATARINA; BOSQUESI, PRISCILA LONGHIN; PECCININI, ROSANGELA GONCALVES; et al. Pharmacological Evaluation and Preliminary Pharmacokinetics Studies of a New Diclofenac Prodrug without Gastric Ulceration Effect. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 13, n. 11, p. 15305-15320, NOV 2012. Web of Science Citations: 6. (10/12495-6, 09/12664-5)
MARTINS, EVELIN DOS SANTOS; OLIVEIRA, JONATA AUGUSTO; FRANCHIN, TAISA BUSARANHO; ULIAN SILVA, BRUNA CRISTINA; CANDIDO, CAROLINE DAMICO; PECCININI, ROSANGELA GONCALVES. Simple and Rapid Method by Ultra High-Performance Liquid Chromatography (UHPLC) with Ultraviolet Detection for Determination of Efavirenz in Plasma: Application in a Preclinical Pharmacokinetic Study. Journal of Chromatographic Science, v. 57, n. 10, p. 874-880, NOV 2019. Web of Science Citations: 0. (11/11239-9, 15/23843-9)
DE CAMPOS, MICHEL LEANDRO; OLIVEIRA, ISABELA JUNQUEIRA; DAVANCO, MARCELO GOMES; DOS SANTOS, JEAN LEANDRO; PECCININI, ROSANGELA GONCALVES. UHPLC Quantitation Method and In vitro Studies of Two New Phthalimide Derivatives Planned to Treat Sickle Cell Disease. CURRENT PHARMACEUTICAL ANALYSIS, v. 13, n. 4, p. 361-366, 2017. Web of Science Citations: 0. (11/23007-5, 14/01724-5)
CAMPOS, MICHEL LEANDRO; ALONSO, JULIANA DE MOURA; MARTINS, EVELIN DOS SANTOS; OLIVEIRA, JONATA AUGUSTO; HUSSNI, CARLOS ALBERTO; PECCININI, ROSANGELA GONCALVES. Ceftriaxone pharmacokinetics by new simple and sensitive ultra-high-performance liquid chromatography method. DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE, v. 88, n. 1, p. 95-99, MAY 2017. Web of Science Citations: 4. (11/11239-9)
TATA, ALESSANDRA; PEREZ, CONSUELO; CAMPOS, MICHEL L.; BAYFIELD, MARK A.; EBERLIN, MARCOS N.; IFA, DEMIAN R.. Imprint Desorption Electrospray Ionization Mass Spectrometry Imaging for Monitoring Secondary Metabolites Production during Antagonistic Interaction of Fungi. Analytical Chemistry, v. 87, n. 24, p. 12298-12304, DEC 15 2015. Web of Science Citations: 14. (13/15575-9, 14/01724-5)
DAVANCO, MARCELO GOMES; CAMPOS, MICHEL LEANDRO; NOGUEIRA, MARCO ANTONIO; CAMPOS, SILVIO LOPES; MARQUES, RICARDO VIAN; DOS SANTOS, JEAN LEANDRO; CHIN, CHUNG MAN; DA FONSECA, LUIZ MARCOS; PECCININI, ROSANGELA GONCALVES. In vitro and in vivo evaluation of a primaquine prodrug without red blood cell membrane destabilization property. BIOPHARMACEUTICS & DRUG DISPOSITION, v. 33, n. 8, p. 437-445, NOV 2012. Web of Science Citations: 2.
CANDIDO, CAROLINE DAMICO; CAMPOS, MICHEL LEANDRO; CORREA VIDIGAL ASSUMPCAO, JULIANA URUGUAY; PESTANA, KELLY CHRYSTINA; PADILHA, ELIAS CARVALHO; CARLOS, IRACILDA ZEPPONE; PECCININI, ROSANGELA GONCALVES. Biocompatible Microemulsion Modifies the Tissue Distribution of Doxorubicin. Journal of Pharmaceutical Sciences, v. 103, n. 10, p. 3297-3301, OCT 2014. Web of Science Citations: 2. (11/11239-9)
FRANCHIN, TAISA BUSARANHO; ULIAN SILVA, BRUNA CRISTINA; DEGRANDIS, RONE APARECIDO; CORREA, MICHELLE FIDELIS; SIMOES DE QUEIROZ ARANHA, CECILIA MARIA; FERNANDES, JOAO PAULO S.; CAMPOS, MICHEL LEANDRO; PECCININI, ROSANGELA GONCALVES. Assessment of the Physicochemical Properties and Stability for Pharmacokinetic Prediction of Pyrazinoic Acid Derivatives. CURRENT DRUG METABOLISM, v. 21, n. 9, p. 714-721, 2020. Web of Science Citations: 0. (16/23139-2, 16/25028-3, 16/23229-1)
ALONSO, J. M.; PECCININI, R. G.; CAMPOS, M. L.; NITTA, T. Y.; AKUTAGAWA, T. Y. M.; CRESCENCIO, A. P.; ALVES, A. L. G.; RODRIGUES, C. A.; WATANABE, M. J.; HUSSNI, C. A.. Plasma and peritoneal fluid concentrations of ceftriaxone after intravenous and intraperitoneal administration in horses. VETERINARY JOURNAL, v. 234, p. 72-76, APR 2018. Web of Science Citations: 0. (13/13799-7, 11/11239-9)
PADILHA, ELIAS C.; WANG, JIANYAO; KERNS, ED; LEE, ARTHUR; HUANG, WENWEI; JIANG, JIAN-KANG; MCKEW, JOHN; MUTLIB, ABDUL; PECCININI, ROSANGELA G.; YU, PAUL B.; et al. Application of in vitro Drug Metabolism Studies in Chemical Structure Optimization for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP). FRONTIERS IN PHARMACOLOGY, v. 10, APR 24 2019. Web of Science Citations: 1. (16/07381-8)
(References retrieved automatically from State of São Paulo Research Institutions)
PADILHA, Elias Carvalho. Desenvolvimento e validação de método bioanalítico aplicado em estudo de farmacocinética pré-clínica e ensaio preliminar de segurança de novo derivado de tiazolidinodiona com atividade antiinflamatória - LYSO-07. 113 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas. (12/21216-9)
CAMPOS, Michel Leandro de. Farmacocinética pré-clínica do composto 1-(2,6-diclorofenil)indolin-2-ona (DICCIC), pró-fármaco de diclofenaco. 97 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciencias Farmaceuticas. Araraquara. (09/12664-5)
FRANCHIN, Taísa Busaranho. Estudo de ADME de compostos derivados do ácido pirazinóico com atividade antimicobacteriana. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas. (16/23229-1)
CAMPOS, Michel Leandro de. Farmacocinética e farmacodinâmica de derivado ftalimídico planejado para o tratamento da anemia falciforme. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas. (11/23007-5)
PINTO, Leonardo Santos Ribeiro. Síntese, atividade antibacteriana e farmacocinética pré-clínica de pró-fármaco do etambutol com potencial terapêutico para meningite tuberculosa. 121 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciencias Farmaceuticas. Araraquara. (08/52754-0)
DAVANÇO, Marcelo Gomes. Farmacocinética do Benznidazol administrado em coelhos na forma de comprimidos de liberação imediata e comprimidos de liberação prolongada. 142 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas. (13/25882-6)
PADILHA, Elias Carvalho. Screening farmacocinético e estudos in vitro para a seleção de tiazolidinodionas promissoras à administração oral. 143 f. Tese (Doutorado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas. (14/20833-0)
MARTINS, Evelin dos Santos. Farmacocinética do efavirenz administrado na forma de micropartículas inorgânicas em coelhos. 106 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciências Farmacêuticas. (15/23843-9)
VIEIRA, Carla Monalizi. Farmacocinética pré-clínica e avaliação toxicológica preliminar da nova tiazolidinadiona desenvolvida para o tratamento do diabetes mellitus tipo 2: 5-(4-cloro-benzilideno)-3-(4-metil-benzil)-tiazolidina-2,4-diona (GQ-2). 113 f. Dissertação (Mestrado) - Universidade Estadual Paulista "Júlio de Mesquita Filho" Faculdade de Ciencias Farmaceuticas. (12/07049-2)